Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A beverage holder includes a frame, an insert, and a cover. The frame includes a sidewall having an upper end and a lower end, and a bottom wall extending across the lower end. The upper end defines a plurality of protrusions. The sidewall and the bottom wall cooperatively define a chamber. The insert includes a peripheral rim defining a plurality of apertures that receive the plurality of protrusions and a flexible collar extending from the peripheral rim and at least partially into the chamber. The flexible collar defines an opening leading to the chamber. The cover includes a plurality of interfaces that engage with the plurality of protrusions to couple the cover to the upper end of the sidewall and to secure the insert between the frame and the cover. The cover defines an aperture that aligns with the chamber and the opening.

Abstract: The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.

Abstract: A sample handler includes a plurality of sealable metering tips, each of the tips, when sealed, containing a fluid volume of a test fluid and in which each of the sealed metering tips acts as an auxiliary sample supply container for use with at least one chemistry system of a clinical analyzer.

Abstract: A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one reagent supply. A wash-free delivery system introduces reagent into at least one reaction containment device without requiring washing of delivery components.

Abstract: A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one reagent supply. A wash-free delivery system introduces reagent into at least one reaction containment device without requiring washing of delivery components.

Abstract: A sample handler includes a plurality of sealable metering tips, each of the tips, when sealed, containing a fluid volume of a test fluid and in which each of the sealed metering tips acts as an auxiliary sample supply container for use with at least one chemistry system of a clinical analyzer.

Abstract: A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one reagent supply. A wash-free delivery system introduces reagent into at least one reaction containment device without requiring washing of delivery components.

Abstract: A method and apparatus for detecting improper liquid content of a metering tip of an analyzer. The method detects the content or status using radiation between 630 and 2000 nm, and comprises the steps of: a) aspirating the liquid into the tips; b) scanning the liquid; c) providing relative motion between the tip and the scanner while simultaneously scanning the liquid; d) detecting the amount of light transmitted to detector at all levels of the liquid; e) comparing the detected light with light known to be transmitted at levels of liquid free of air bubbles; and flagging the results.

Abstract: Apparatus and method for detecting patient sample quality, and/or analytes, in the tip used to aspirate the patient sample liquid and then dispense it onto a slide test element. Spectrophotometric analysis is done on the liquid while still in the tip, by scanning the tip for transmittance in a light-tight enclosure, using NIR and adjacent visible radiation, and detecting the absorbance spectra of the liquid. Thereafter, or prior thereto, the liquid is dispensed onto a dried slide test element for assaying analytes that are not assayed spectrophotometrically, thus enhancing throughput.

Abstract: Apparatus and method for detecting patient sample quality, and/or analytes, in the tip used to aspirate the patient sample liquid and then dispense it onto a slide test element. Spectrophotometric analysis is done on the liquid while still in the tip, by scanning the tip for transmittance in a light-tight enclosure, using NIR and adjacent visible radiation, and detecting the absorbence spectra of the liquid. Much smaller liquid volumes, and no through-the-label detection, are required, compared to doing the scanning of the liquid in a primary patient collection container.