Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A pressure contained car cannon for the launching and/or flipping of vehicles, or other large-scale props, for use in motion picture action sequences. The device consists of a car canon having a barrel, a cannon foot and a piston. By way of pneumatic pressure, force is achieved by transferring energy from the piston to the cannon foot, resulting in a push force which expels the cannon foot from the cannon barrel, launching the vehicle on its desired trajectory while keeping most all vapor and smoke contained within the barrel itself.

Abstract: An adjustable length power strip that is designed to protect connected electrical devices from power surges. The apparatus is configured to resemble traditional power strips and extension cords. The apparatus includes a primary power strip an extension cord and a secondary power strip. The primary power strip is connected to an external power source and is used to distribute electrical power to the secondary power strip. The extension cord is situated between the primary power strip and the secondary power strip and electrically connects the two power strips. The secondary power strip enables a user to power connected electrical devices. Additionally, a user may connect multiple secondary power strips together in a chain. This is accomplished by connecting the extension cord of one secondary power strip to another secondary power strip.

Abstract: A suppository insertion tool is a device utilized to administer a suppository within the body as well as to detect the presence of an obstruction within the bowels. A semi-rigid plunger member is telescopically engaged into a tubular semi-rigid sleeve member. A suppository-receiving flexible end of the tubular semi-rigid sleeve member and an expandable opening traversing into the suppository-receiving flexible end are expanded when the semi-rigid plunger member is engaged into the tubular semi-rigid sleeve member. A suppository may then be inserted through the expandable opening. A plurality of color-coded blockage indicators may be utilized to detect the presence and severity of an obstruction within the bowels. The plurality of color-coded blockage indicators is offset from each other to accurately gauge the severity of an obstruction. A chemical reactant coating for various applications may be applied to a sleeve tubular body of the tubular semi-rigid sleeve member.

Abstract: A showerhead attachment for controlling the flow and temperature of water is a device that is utilized to minimize water waste and the risk of being scalded by hot water when showering. Water from a faucet or similar water source enters a casing through an inlet and exits through an outlet. A valve is positioned within a flow tube that connects the inlet and the outlet within the casing. The valve is utilized to automatically enable and disable water flow as well as to regulate the flowrate of the water. A proximity sensor detects a user's presence in the proximity of the device and water flow is disabled if the user is not detected to minimize waste. A temperature sensor is able to detect if water is too hot and water flow is automatically disabled if the water temperature is deemed unsafe.

Abstract: A water display is described having a lighting array emanating light that travels through a wall. Water flows down the wall to vary the appearance of the light that shines through the wall. The flow of water and particular lights being turned on and off may be controlled. Dramatic visual effects are provided including the appearance of moving art.

Abstract: Described herein are filter assemblies for removing high molecular weight organic components from liquefied petroleum gas, as well as methods for removing high molecular weight components from liquefied petroleum gases. The filter assemblies include an upstream carbon-containing filter media pack and a downstream filter media pack.

Abstract: Described herein are filter assemblies for removing high molecular weight organic components from liquefied petroleum gas, as well as methods for removing high molecular weight components from liquefied petroleum gases. The filter assemblies include an upstream carbon-containing filter media pack and a downstream filter media pack.

Abstract: A twist drill assembly (10) comprising a shaft (30) and a drill tip (20); the shaft having a single internal shaft conduit (34) for a fluid, extending between orifices (36, 37) formed into the shaft; the drill tip having an internal drill tip conduit (22) for the fluid, extending between orifices formed into the drill tip; the shaft and the drill tip configured such that the drill tip is connectable to an end of the shaft with the internal drill tip conduit in communication with the internal shaft conduit, allowing the fluid to be capable of flowing from the internal shaft conduit into the internal drill tip conduit; the internal shaft conduit having a spiral form aligned with a central longitudinal axis of the shaft, and configured to complement the arrangement of spiral flutes (38) formed on the shaft.

Abstract: A support structure (40) for a PCD element comprises a support (42) into which a plurality of PCD elements are locatable, and a plurality of sealing elements (48) for location in the support structure. Each sealing element (48) is configured to protect a non-leached portion of an associated PCD element during a leaching process, said support being formed from or coated with a polyketone based plastics material. A plurality of support structures (42) may be stacked on top of each other and a central support rod (52) is locatable in a central aperture (50) extending though the stack of support structures (42). A handle (54) may be attached to the central support rod (52) for ease of transporting the assembled support structure.

Abstract: A support structure (40) for a PCD element (10) comprises a support (42) into which a PCD element (10) is locatable and a sealing element (48) for location in the support structure (40) and configured to protect a non-leached portion of a PCD element (10) during a leaching process. The support (42) is formed from or coated with a polyketone based plastics material.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Disclosed herein are embodiments of combined cycle power plants having elevated exhaust pressure from a steam turbine. The elevated exhaust pressure from the steam turbine may result in an elevated condensate pressure and temperature. A cooling system removes sensible heat from the condensate. The elevated condensate temperature results in a greater temperature difference between the condensate and the working medium in the cooling system. The amount of heat that is dissipated by the cooling system is proportionate to the heat transfer surface and the temperature difference between the condensate and the working medium. As a result of the greater temperature difference, a smaller cooling system configured to operate with a higher temperature condensate may be utilized in place of a larger cooling system configured to operate with lower temperature condensate. By reducing the size of the cooling system, the overall size of the combined cycle power plant may be reduced.

Abstract: A water display is described having a lighting array emanating light that travels through a wall. Water flows down the wall to vary the appearance of the light that shines through the wall. The flow of water and particular lights being turned on and off may be controlled. Dramatic visual effects are provided including the appearance of moving art.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: An ice display device includes a chill tube and a piston that slides within the chill tube providing a fluidtight seal against the interior. The tube is filled with water and cooled to form an ice column. A shutter may selectively close the upper end of the chill tube with a fluidtight seal while the ice column is formed. The tube is warmed and the piston is lifted to an upper end of the tube to display the ice column. A plurality of water nozzles may selectively discharge streams of high pressure water inwardly to sculpt the ice column. An armature may extend upwardly from the piston to support and cool an interior of the ice column. The tube and armature may be cooled and warmed by a thermal transfer fluid. A device may be provided to induce turbulence in the thermal transfer fluid.

Abstract: A processing system includes a memory module that stores an electronic program guide (EPG) authoring application. A processing module executes the EPG authoring application including a graphical user interface that responds to input from an end user. The EPG authoring application creates EPG configuration data to configure an EPG application of a client device associated with the end user.

Abstract: A twist drill assembly (10) comprising a shaft (30) and a drill tip (20); the shaft having a single internal shaft conduit (34) for a fluid, extending between orifices (36, 37) formed into the shaft; the drill tip having an internal drill tip conduit (22) for the fluid, extending between orifices formed into the drill tip; the shaft and the drill tip configured such that the drill tip is connectable to an end of the shaft with the internal drill tip conduit in communication with the internal shaft conduit, allowing the fluid to be capable of flowing from the internal shaft conduit into the internal drill tip conduit; the internal shaft conduit having a spiral form aligned with a central longitudinal axis of the shaft, and configured to complement the arrangement of spiral flutes (38) formed on the shaft.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium are presented, for providing incident notifications. The systems and processes disclosed here automatically generate and send notifications relating to an incident in accordance with an enterprise's business rules and provide real time reporting of all communications relating to the incident.

Abstract: The web of the invention can comprise a super absorbent layer that can act as an moisture sensitive fuel shut-off valve, absorbent, adsorbant or reactant. The web of the invention can comprise a super absorbent fabric or layer made of a superabsorbent particle or fiber. Fluid, gas or liquid, that flows through or by the assemblies of the invention can have any gas, liquid or solid material dispersed or dissolved in the fluid interact with the super absorbent particulate. The structures of the invention can act simply as flow-by reactive, absorptive, or adsorptive layers with no filtration properties, or the structures of the invention can be assembled into filters.