Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.

Abstract: The technologies described herein are generally directed to configuring carrier aggregation zones based on transmission information in a fifth generation (5G) network or other next generation networks. For example, a method described herein can include identifying, by carrier aggregation equipment including a processor, carrier transmission information corresponding to a first carrier signal and a second carrier signal. The method can further include analyzing, by the carrier aggregation equipment, the carrier transmission information to determine first overlap zone information representative of a first carrier overlap zone for the first carrier signal and the second carrier signal. Further, based on the first overlap zone information, the method includes facilitating configuring transmission parameter information representative of a transmission parameter applicable to transmission of the first carrier signal, to enable carrier aggregation by network equipment within the first carrier overlap zone.

Abstract: Techniques of audio-video synchronization that can be performed on audio and video streams are described. In one scenario, a processor can receive audio-video information comprising a video stream and an audio stream. Each of the video and audio streams can include one or more of: a compressed stream; and a decoded stream. A region of motion in the video stream can be determined based on a property of the video stream. A video signal can be generated based on the determined region of motion. Also, a relative delay between the streams can be determined based, at least in part, on the generated video signal. A delay value associated with one or more of the audio and video streams may be adjusted to assist with synchronizing the audio and video streams.

Abstract: An insulated beer-keg container having a freely hanging, or suspended, internal harness. The length of the harness is chosen independently of the lengths of the remaining materials of the container and sufficiently shorter than the lengths of those materials that there is no loading of the materials when a keg is carried within the container by handles connected to the harness.

Abstract: The suture is released by opening and withdrawing the tip from the guide. The suture is recovered by using the guide to redirect the tip and puncturing the tissue opposite the first point of insertion. The tip grasps the suture and pulls the suture through the guide. The suture is pulled outside the wound, providing for rapid closure of the surgical incision. The guide is insertable within the wound to be closed and guides the surgical instrument at a predetermined angle from the longitudinal axis of the guide for optimum wound closure. The surgical instrument and method may be used to advantageously shorten and strengthen ligaments. For example, by gathering and reinforcing the round ligament that supports a woman's uterus with suture materials, surgeons can reposition and stabilize a retroverted uterus. Other devices may be also used in connection with retracting and reinforcing connective tissue.

Abstract: A surgical instrument, guide, and method capable of being used for closure of peritoneum fascia, occlusion of bleeding vessels such as inferior epigastric, and for all uses related to accurately passing suture material through a guide into tissue. A tip of a surgical instrument in a standard suture-needle-driving position with a sharp tip that opens and closes with the surgeon grasping suture material with the sharp tip is provided. Insertion of the tip/suture through tissue until the tip is seen through the peritoneum by direct vision begins the wound-closing procedure. The suture is released by opening and withdrawing the tip from the guide. The suture is recovered by using the guide to redirect the tip and puncturing the tissue opposite the first point of insertion. The tip grasps the suture and pulls the suture through the guide. The suture is pulled outside the wound, providing for rapid closure of the surgical incision.

Abstract: A surgical instrument, guide, and method capable of being used for closure of peritoneum fascia, occlusion of bleeding vessels such as inferior epigastric, and for all uses related to accurately passing suture material through a guide into tissue. A tip of a surgical instrument in a standard suture-/needle-driving position with a sharp tip that opens and closes with the surgeon grasping suture material with the sharp tip is provided. Insertion of the tip/suture through tissue until the tip is seen through the peritoneum by direct vision begins the wound-closing procedure. The suture is released by opening and withdrawing the tip from the guide. The suture is recovered by using the guide to redirect the tip and puncturing the tissue opposite the first point of insertion. The tip grasps the suture and pulls the suture through the guide. The suture is pulled outside the wound, providing for rapid closure of the surgical incision.

Abstract: A surgical instrument, guide, and method capable of being used for closure of peritoneum fascia, occlusion of bleeding vessels such as inferior epigastric, and for all uses related to accurately passing suture material through a guide into tissue. A tip of a surgical instrument in a standard suture-/needle-driving position with a sharp tip that opens and closes with the surgeon grasping suture material with the sharp tip is provided. Insertion of the tip/suture through tissue until the tip is seen through the peritoneum by direct vision begins the wound-closing procedure. The suture is released by opening and withdrawing the tip from the guide. The suture is recovered by using the guide to redirect the tip and puncturing the tissue opposite the first point of insertion. The tip grasps the suture and pulls the suture through the guide. The suture is pulled outside the wound, providing for rapid closure of the surgical incision.

Abstract: A facsimile jack selectively routes a facsimile transmission over a packet switched digital network including a source point of presence (source POP) which is local to a facsimile machine sending the facsimile transmission and a destination point of presence (destination POP) which is local to a facsimile machine receiving the facsimile transmission. The facsimile jack is connected between a facsimile machine and a telephone jack and includes a processor which determines if a destination number of the facsimile transmission is serviced by the facsimile network. If the destination number is long distance and is serviced by the facsimile network, the processor instructs a local number of the source POP to be dialed and the facsimile transmission to be sent through the source POP. If not, then other network route paths can be dialed (WATS, VPN, etc.).

Abstract: A surgical instrument, guide, and method capable of being used for closure of peritoneum fascia, occlusion of bleeding vessels such as inferior epigastric, and for all uses related to accurately passing suture material through a guide into tissue. A tip of a surgical instrument in a standard suture-/needle-driving position with a sharp tip that opens and closes with the surgeon grasping suture material with the sharp tip is provided. Insertion of the tip/suture through tissue until the tip is seen through the peritoneum by direct vision begins the wound-closing procedure. The suture is released by opening and withdrawing the tip from the guide. The suture is recovered by using the guide to redirect the tip and puncturing the tissue opposite the first point of insertion. The tip grasps the suture and pulls the suture through the guide. The suture is pulled outside the wound, providing for rapid closure of the surgical incision.

Abstract: A surgical instrument, guide, and method capable of being used for closure of peritoneum fascia, occlusion of bleeding vessels such as inferior epigastric, and for all uses related to accurately passing suture material through a guide into tissue. A tip of a surgical instrument in a standard suture-/needle-driving position with a sharp tip that opens and closes with the surgeon grasping suture material with the sharp tip is provided. Insertion of the tip/suture through tissue until the tip is seen through the peritoneum by direct vision begins the wound-closing procedure. The suture is released by opening and withdrawing the tip from the guide. The suture is recovered by using the guide to redirect the tip and puncturing the tissue opposite the first point of insertion. The tip grasps the suture and pulls the suture through the guide. The suture is pulled outside the wound, providing for rapid closure of the surgical incision.

Abstract: A manual dilating trocar uses an automatically retracting stylet. The stylet is threaded through a dilating obturator which is, in turn, inserted into a trocar sheath. A spring near the handle of the stylet serves to urge the stylet cutting tip into a retracted position so that it can be held within the dilating tip of the dilating obturator. When a surgeon seeks to pierce a body cavity so as to perform laparoscopic surgery or the like, the handle is engaged to overcome the bias of the spring so that the stylet's cutting tip is exposed. Upon piercing of the exterior body-cavity layer, the stylet may be withdrawn to ensure that no underlying organs or tissue are damaged by the sharp stylet tip. Once the dilation of the initial stylet wound has been completed and the trocar sheath has been introduced into the body cavity, the dilating obturator may also be removed from within the trocar sheath in order to provide a channel into the body cavity.

Abstract: A surgical instrument, guide and method capable of being used for closure of peritoneum fascia, occlusion of bleeding vessels such as inferior epigastric, and for all uses related to accurately passing suture material through a guide into tissue with the tip of the surgical instrument in a standard suture/needle driving position with a sharp tip that opens and closes with the surgeon grasping suture material with the sharp tip and inserting the tip/suture through tissue until the tip is seen through the peritoneum by direct vision, wherein the suture is released by opening and withdrawing the tip from the guide, and recovered by using the guide to redirect the tip and puncturing the tissue opposite the first point of insertion wherein the tip grasps the suture and pulls the suture through the guide, and outside the wound providing for rapid closure of the surgical incision, and wherein a guide insertable within the wound to be closed guides the surgical instrument at a predetermined angle from the longitudina

Abstract: A surgical instrument and method capable of being used for closure of peritoneum fascia, occlusion of bleeding vessels such as inferior epigastric, and for all uses related to passing of suture through tissue with the tip of the surgical instrument in a standard suture/needle driving position with a sharp tip that opens and closes with the surgeon grasping suture material with the sharp tip and inserting the tip/suture through tissue until the tip is seen through the peritoneum by direct vision wherein the suture is released by opening and withdrawing the tip and recovered by puncturing the tissue opposite the first point of insertion wherein the tip grasps the suture and pulls the suture outside the wound providing for rapid closure of the surgical incision.

Abstract: The protective leg or arm covering is manufactured from a sheet of material that is cut or sewn into a blank having the shape to protect the portion of the leg or arm desired.

Abstract: A debris/storage bag that attaches with straps connected to at least two different sides of the bag. The straps are designed to attach to both fixed and variable distances. The debris/storage bag features: (1) a pocket or pockets attached preferably to the exterior of the bag; (2) a flap covering for the opening of the debris/storage bag that can be fastened to keep the contents of the bag from falling out; (3) elastic and non-elastic straps used in conjunction with adjustable fasteners to attach the debris/storage bag to a wide variety of objects with different size circumferences and varying distances between the top and bottom fastening positions.

Abstract: A protective leg or arm covering is manufactured from a single piece of material. The material is cut into a blank having the shape to fit the purpose needed to protect the portion of the leg or arm desired. It is designed to be wrapped around the leg or arm, securing snugly but comfortably in the area of protection from the top of the leg or arm with the lateral edges extending to the bottom of the leg or arm or any partial area in between. A hook and pile closure sewn at the corners of the top and the bottom elevations of said blank of material provides the user with adjustability to the desired snugness of the fit. A hook and pile closure sewn along the lateral edges of said blank of material provides the user with full or partial protection from anything that would penetrate or enter the opening along said lateral edges.

Abstract: A protective leg covering is manufactured from a single piece of material. The material is cut into a blank having a rectangular shape. It is designed to be wrapped around the leg, securing snugly but comfortably two to three inches above the knee with the longitudinal edges of the leg section extending down to the top of the arch of the foot in front and above the bottom of the heel in back. A hook and pile closure sewn at the corners of the top and the bottom elevations of said blank of material provides the user with adjustability to the desired snugness of the fit. The device is light weight, having no metal strips, straps or other heavy objects required in its construction, requires nothing to be removed or adjusted on the leg or foot to be attached to the leg of the wearer, and is easy and quick to put on and take off.