Abstract: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

Abstract: This invention provides novel 5-HT.sub.1F agonists of formula ##STR1## where X, Y, Z,and R are defined in the specification, which are useful for the prevention and treatment of migraine and associated disorders.

Abstract: A connector block (10) for connecting signal transmission lines in a blast initiation system includes a body member (12) having a channel (18) formed therein for receiving and retaining a detonator (20). A locking member (28) is mounted on the body member (12) in a first position aligned with, but displaced from, its locking position. The detonator (20) is inserted into the channel (18) of the connector block (10) and, if axially misaligned, is properly seated therein by moving the locking member (28) through a passageway (36) to both axially shift the detonator (20) to its seated position and engage the locking member (28) and the detonator with each other to secure both within the channel (18). A method of assembling a detonator (20) within the connector block (10) to provide a combination of detonator (20) and connector block (10) is also provided.

Abstract: A connector block (10) includes a clip member (30) which cooperates with the signal transmission end (12a) of body member (12) to define therebetween an arcuate line-retaining slot (32) within which one or more signal transmission lines (40) are received in explosive signal communication with the output end (16a) of a detonator (16). Clip member (30) is of decreasing thickness as sensed moving from the proximal end (30b) thereof towards at least its mid-point and is preferably of undiminished width from the proximal end (30b) thereof to the open end (32b) of the line-retaining slot (32). These features and the configuration of the entryway (34) cooperate to facilitate lateral insertion of signal transmission lines (40) into the line-retaining slot (32) and their retention therein over a broad temperature range of use, and provide excellent shrapnel shielding.

Abstract: The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.

Abstract: A pulverable casing (10) includes a housing (12) which is made from a ceramic material and which defines a circular housing closure surface (18). There is a cover (14) on the housing (12). The cover (14) is also made from a ceramic material and defines a circular cover closure surface (20). Cover (14) has a rounded conical exterior surface (24) that defines a skirt angle S of about 120.degree.. The cover closure surface (20) is dimensioned and configured to engage the housing closure surface (18) to define a housing-cover joint (22) which defines a joint angle .alpha. of about 130.degree.. In a particular embodiment, the exterior surface (24) of the cover (14) is rounded to a radius of about 1.8 inches and has a diameter D of about 3.28 inches.

Abstract: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

Abstract: A well pipe perforating gun (10) is improved by the utilization of a pulverable support structure (14) to hold the explosive shaped charges (18a, 18b, etc.) and the fireset (20). When the gun (10) is fired, the support structure (14) disintegrates substantially into fragments too small to obstruct the flow of oil or natural gas from a surrounding earth formation into or through the well pipe (12) within which the gun is disposed. Optionally, the support structure (14) is assembled from a number of segments (14a, 14b, etc.) linked together in sequential fashion.

Abstract: The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.

Abstract: The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating HIV infection.

Abstract: Fortified hydrocarbon torch gas is a mixture of a major portion by weight of hydrocarbon base gas and additive selected from 1,2-ethanediol, 1,2-propanediol, 1,3 butanediol, glycerol, diethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol dimethyl ether, ethyl acetate, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, sec butyl alcohol, methyl ethyl ketone, propionaldehyde, and butyraldehyde and liquid hydrocarbon fuel fortified with ethylene glycol monomethyl ether or ethyl acetate.

Abstract: Base hydrocarbon, preferably LPG gas, is fortified with methyl ethyl ketone and methyl tertbutyl ether in an amount 0.5% to 13%, preferably 5% to 8%, of the base hydrocarbon by weight for use as torch gas, heating or motor fuel. Cutting of ferrous metal can be accomplished even under water by mixing the fortified torch gas with oxygen having a purity as low as 90%.