Patents by Inventor James E. Garrett, Jr.

James E. Garrett, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Calcium receptor-active molecules
    Patent number: 5962314
    Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: October 5, 1999
    Assignees: NPS Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Edward M. Brown, Steven C. Hebert, James E. Garrett, Jr.
  • Method of screening calcium receptor-active molecules
    Patent number: 5858684
    Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 12, 1999
    Assignees: The Brigham and Women's Hospital, Inc., NPS Pharmaceuticals, Inc.
    Inventors: Edward F. Nemeth, Edward M. Brown, Steven C. Hebert, James E. Garrett, Jr., Bradford C. Van Wagenen, Manuel F. Balandrin, Eric G. Del Mar
  • Calcium receptor-active molecules
    Patent number: 5763569
    Abstract: The present invention features calcium receptor polypeptides and fragments thereof. Uses of a calcium receptor polypeptide include providing a polypeptide having the activity of a calcium receptor polypeptide. Calcium receptor polypeptide fragments can be used, for example, to generate antibodies to a calcium receptor polypeptide.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 9, 1998
    Assignees: The Brigham and Women's Hospital, Inc, NPS Pharmaceuticals, Inc.
    Inventors: Edward M. Brown, Steven C. Hebert, James E. Garrett, Jr.
  • Calcium receptor-active molecules
    Patent number: 5688938
    Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignees: The Brigham & Women's Hospital, Inc., NPS Pharmaceuticals, Inc.
    Inventors: Edward M. Brown, Forrest H. Fuller, Steven C. Hebert, James E. Garrett, Jr.