Patents by Inventor James E. Hopper

James E. Hopper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MGAL: A GAL Gene Switch-Based Suite of Methods for Protein Analyses and Protein Expression in Multicellular Organisms and Cells Therefrom
    Publication number: 20080249045
    Abstract: The invention provides methods for detecting and analyzing protein-protein interactions and agonists and antagonists thereof, detecting and analyzing protein sequences, and regulatable gene expression in multicellular organisms or cells therefrom.
    Type: Application
    Filed: May 31, 2007
    Publication date: October 9, 2008
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Vepkhia Pilauri, James E. Hopper, Gang Peng, Tamara Vyshkina
  • M-GAL: a Gal gene switch-based suite of methods protein analyses and protein expression in multicellular organisms and cells therefrom
    Patent number: 7229766
    Abstract: The invention provides methods for detecting and analyzing protein-protein interactions and agonists and antagonists thereof, detecting and analyzing protein sequences, and regulatable gene expression in multicellular organisms or cells therefrom.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: June 12, 2007
    Assignee: The Penn State Research Foundation
    Inventors: Vepkhia Pilauri, James E. Hopper, Gang Peng, Tamara Vyshkina
  • Reagents and methods for detection and characterization of protein-protein interactions, nuclear export and localization sequences and inducible Gal4p-mediated gene expression in yeast
    Patent number: 6878524
    Abstract: This invention provides methods for cytoplasmic detection of protein—protein interactions, nuclear export/localization sequences, and galactose-independent inducible Gal4p-mediated gene expression through the utilization of GAL regulatory factor, Gal80p, and the yeast galactose regulon.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: April 12, 2005
    Inventors: Gang Peng, James E. Hopper, Tamara Vyshkina
  • M-GAL: a Gal gene switch-based suite of methods protein analyses and protein expression in multicellular organisms and cells therefrom
    Publication number: 20040058368
    Abstract: The invention provides methods for detecting and analyzing protein-protein interactions and agonists and antagonists thereof, detecting and analyzing protein sequences, and regulatable gene expression in multicellular organisms or cells therefrom.
    Type: Application
    Filed: June 20, 2003
    Publication date: March 25, 2004
    Inventors: Vepkhia Pilauri, James E. Hopper, Gang Peng, Tamara Vyshkina
  • High copy number recombinant expression construct for regulated high-level production of polypeptides in yeast
    Patent number: 6221630
    Abstract: The invention provides methods and recombinant expression constructs for inducing and sustaining high-level production of a recombinant polypeptide in yeast. The invention specifically provides high copy number recombinant expression constructs that express high levels of trans-acting transcription factors that in turn induce expression of a recombinant nucleic acid encoding a heterologous or endogenous recombinant polypeptide. The invention more specifically provides constructs that express galactose-inducible and temperature-sensitive transcription factors. The invention also provides constructs comprising nucleic acids the transcription of which is regulated by the transcription factors expressed by the construct. The invention also provides yeast cells transformed by the recombinant expression constructs of the invention that permit sustained high-level expression of a recombinant polypeptide.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: April 24, 2001
    Assignee: The Penn State Research Foundation
    Inventor: James E. Hopper
  • Trains of yeast for the expression of heterologous genes
    Patent number: 5068185
    Abstract: The GAL4 protein is rate-limiting in quantity as a positive regulator for galactose-inducible promoters in strains of yeast. Novel strains are described in which the GAL4 protein can be overproduced in a regulatable fashion. These strains are useful for the regulatable expression in yeast of heterologous genes whose expression is driven by a galactose-inducible promoter.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: November 26, 1991
    Assignee: Merck & Co., Inc.
    Inventors: James E. Hopper, Loren D. Schultz, Kathryn J. Hofmann, Ronald W. Ellis
  • Quick coupler latch
    Patent number: 4549744
    Abstract: A quick coupler latch mechanism includes a latch pivoted on a quick coupler frame above a hook having a recess. A guide pin extends horizontally through the frame and is supported by thickened frame parts to resist bending deformation of the guide pin. An operator-controlled lever device moves a control bar within the frame. A guide member is rigidly fixed for movement with the lower end of the control bar and has a recess which slidably receives the guide pin. The guide member operatively engages the latch to pivot it between open and closed positions.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: October 29, 1985
    Assignee: Deere & Company
    Inventors: Herbert W. Herr, Seaton Moon, James E. Hopper