Abstract: The present invention relates to stable therapeutic compositions of pharmaceutical grade acids and pH buffering agents. The present invention also is directed to methods of treatment for mitochondrial disorders, metabolic conditions, diabetic conditions, and cardiovascular conditions, by administration of compositions of the present disclosure.

Abstract: The present invention relates to stable therapeutic compositions of pharmaceutical grade acids and pH buffering agents. The present invention also is directed to methods of treatment for mitochondrial disorders, metabolic conditions, diabetic conditions, and cardiovascular conditions, by administration of compositions of the present disclosure.

Abstract: The present invention relates to stable therapeutic compositions of pharmaceutical grade acids and pH buffering agents. The present invention also is directed to methods of treatment for mitochondrial disorders, metabolic conditions, diabetic conditions, and cardiovascular conditions, by administration of compositions of the present disclosure.

Abstract: This disclosure provides compositions and methods for improving outcomes in cancer patients.

Abstract: The present invention relates to stable therapeutic compositions of pharmaceutical grade acids and pH buffering agents. The present invention also is directed to methods of treatment for mitochondrial disorders, metabolic conditions, diabetic conditions, and cardiovascular conditions, by administration of compositions of the present disclosure.

Abstract: The present invention relates to stable therapeutic compositions of pharmaceutical grade acids and pH buffering agents. The present invention also is directed to methods of treatment for mitochondrial disorders, metabolic conditions, diabetic conditions, and cardiovascular conditions, by administration of compositions of the present disclosure.

Abstract: A method, system and apparatus for medication therapy management programs. One embodiment of the invention includes a comprehensive, technology-enhanced pharmacy system for patients following a complex medication to regimen comprising a treatment database, communications interface, and a personal medication cartridge configured to store medication and configured based on a treatment optimization algorithm. Another embodiment of the invention includes a medication administration apparatus comprising computer processing hardware, a user interface, an interface for receiving a personal medication cartridge including medication dose packets labeled with computer-readable identification or an RFID mechanism, a medication ejection mechanism, and a medication dispensing sensor. The medication administration apparatus utilizes medication dose packets and prescription information and identifies individual dose packets using computer-readable information or an RFID mechanism.

Abstract: A swivel assembly for an actuator includes: a rod defining a socket, the rod defining an arcuate surface at the floor of the socket; a cap dimensioned to fit into the socket, the cap defining a convex arcuate surface dimensioned to correspond to the arcuate surface of the floor of the socket; a first extended surface defined by the rod, the first extended surface, defined at least in part, by side portions of the socket providing depth to the socket; a second extended surface defined by the cap providing an extended length to the cap to allow the cap to extend out of the socket when the convex arcuate surface of the cap contacts the arcuate surface of the floor of the socket; and a cylinder assembly operatively connected to a piston and the cap to permit the piston and cap to move axially along a longitudinal axis of the cylinder assembly to move inwardly and outwardly of the cylinder assembly.

Abstract: Methods and systems are provided for tracking and guiding a patient's clinically directed medication usage. Medicaments are placed in secure passive packaging that must be unlocked to enable dispensing of a dose or a set of doses. This packaging is designed to be difficult to open manually, and instead is designed to dispense only when used in combination with a smart key. The smart key is a separate device containing electronics, mechatronics or both, to unlock and dispense from the packaging and to track and guide usage. Together, the secure container and the smart key track medication usage, trigger reminders in accordance with actual patient data, deter an excessive rate of patient usage, and deter unauthorized access to medication.

Abstract: The present disclosure relates to a linked crank mounting device for use with a switch rail, comprising: an input terminal or series of input terminals; an actuator; an output connector; and attachment means for rigidly attaching the linked crank mounting device relative to the railway; wherein the input terminal or terminals are for receiving input power, the output connector is directly or indirectly mechanically linked to at least one of a switch rail or an output connector of a further linked crank mounting device, and the actuator applies the input power to the output connector.

Abstract: Methods and systems are provided for tracking and guiding a patient's clinically directed medication usage. Medicaments are placed in secure passive packaging that must be unlocked to enable dispensing of a dose or a set of doses. This packaging is designed to be difficult to open manually, and instead is designed to dispense only when used in combination with a smart key. The smart key is a separate device containing electronics, mechatronics or both, to unlock and dispense from the packaging and to track and guide usage. Together, the secure container and the smart key track medication usage, trigger reminders in accordance with actual patient data, deter an excessive rate of patient usage, and deter unauthorized access to medication.

Abstract: A swivel assembly for an actuator includes: a rod defining a socket, the rod defining an arcuate surface at the floor of the socket; a cap dimensioned to fit into the socket, the cap defining a convex arcuate surface dimensioned to correspond to the arcuate surface of the floor of the socket; a first extended surface defined by the rod, the first extended surface, defined at least in part, by side portions of the socket providing depth to the socket; a second extended surface defined by the cap providing an extended length to the cap to allow the cap to extend out of the socket when the convex arcuate surface of the cap contacts the arcuate surface of the floor of the socket; and a cylinder assembly operatively connected to a piston and the cap to permit the piston and cap to move axially along a longitudinal axis of the cylinder assembly to move inwardly and outwardly of the cylinder assembly.

Abstract: A method, system and apparatus for medication therapy management programs. One embodiment of the invention includes a comprehensive, technology-enhanced pharmacy system for patients following a complex medication to regimen comprising a treatment database, communications interface, and a personal medication cartridge configured to store medication and configured based on a treatment optimization algorithm. Another embodiment of the invention includes a medication administration apparatus comprising computer processing hardware, a user interface, an interface for receiving a personal medication cartridge including medication dose packets labeled with computer-readable identification or an RFID mechanism, a medication ejection mechanism, and a medication dispensing sensor. The medication administration apparatus utilizes medication dose packets and prescription information and identifies individual dose packets using computer-readable information or an RFID mechanism.

Abstract: The present disclosure relates to a linked crank mounting device for use with a switch rail, comprising: an input terminal or series of input terminals; an actuator; an output connector; and attachment means for rigidly attaching the linked crank mounting device relative to the railway; wherein the input terminal or terminals are for receiving input power, the output connector is directly or indirectly mechanically linked to at least one of a switch rail or an output connector of a further linked crank mounting device, and the actuator applies the input power to the output connector.

Abstract: A piston assembly is provided. The piston assembly may include: a piston rod; a piston pivotally connected to the piston rod; and a rotatable rod bearing configured to allow the piston rod to pass therethough and rotate along with the piston rod as the piston rod pivots with respect to the piston. A method of making a piston assembly may be provided. The method may include: attaching a piston rod to a piston in a pivoting connection; providing a rotatable bearing for the piston rod; and supporting the piston rod with the rotatable bearing.

Abstract: A method of operating an engine including at least a cylinder and a valve controlled by an electric valve actuator is disclosed. In one example, a valve holding current is determined during movement of the valve. The method may be useful for determining individual holding currents for specific valve actuators.

Abstract: A method of operating an engine having at least one cylinder, said cylinder including at least one electric valve actuator, said actuator including at least a coil and an armature moveable thereto, the method comprising during a non-firing state of the cylinder: holding the armature of the actuator at a first position away from an equilibrium position by supplying a first amount of current to a first coil of the actuator; and reducing current supplied to the first coil from said first amount to a lower second amount to cause the armature to begin moving toward the equilibrium position; and during a subsequent firing state of the cylinder, varying an amount of holding current supplied to the first coil for holding the armature away from the equilibrium position based on at least said second amount of current.

Abstract: A method of operating an engine including at least a cylinder and a valve controlled by an electric valve actuator, said actuator including at least a coil and an armature moveable thereto, said armature coupled to said valve, the method comprising of moving the armature toward the coil by varying an amount of current supplied to the coil in response to a location of the armature relative to the coil; identifying a first level of current supplied to the coil at a first position of the armature during said moving the armature toward the coil; and holding the armature at a second position relative to the coil by supplying a holding current to the coil, wherein said holding current is adjusted to be less than said first level of current.

Abstract: A method of operating an engine having at least one cylinder, said cylinder including at least one electric valve actuator, said actuator including at least a coil and an armature moveable thereto, the method comprising during a non-firing state of the cylinder: holding the armature of the actuator at a first position away from an equilibrium position by supplying a first amount of current to a first coil of the actuator; and reducing current supplied to the first coil from said first amount to a lower second amount to cause the armature to begin moving toward the equilibrium position; and during a subsequent firing state of the cylinder, varying an amount of holding current supplied to the first coil for holding the armature away from the equilibrium position based on at least said second amount of current.

Abstract: An electronically controlled valve actuator having a hydraulic lever in the form of a fluid filled chamber, is used to amplify the motion of a magnetic armature and thereby achieve a desired valve displacement with reduced effective travel of the armature, reduced transition time and power consumption while incorporating passive hydraulic lash adjustment in the hydraulic lever mechanism.