Abstract: Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate oligonucleotides can have advantageous properties, for example in the form of defined multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced intracellular delivery and/or multigene silencing effects. In various embodiment, the defined multi-conjugate oligonucleotides can be synthesized via new synthetic intermediates and methods. The defined multi-conjugate oligonucleotides can be used, for example, in reducing gene expression, biological research, treating or preventing medical conditions, or t9o produce new or altered phenotypes in cells or organisms.

Abstract: Methods, systems, and media for a computing device comprising; receiving a plurality of container snapshots for operating an edge device, wherein the container snapshots include an operating system (OS) snapshot and a plurality of application snapshots; writing the OS snapshot into a read-only partition; writing the plurality of application snapshots into a writable partition as a plurality of overlay mounted container snapshot layers; obtaining metadata for each of the plurality of application snapshots; generating a merged collection of metadata using the metadata for each of the plurality of snapshots; executing the OS snapshot including a container runtime tool; and executing, using the container runtime tool, one or more containers using the plurality of overlay mounted container snapshot layers.

Abstract: A tiltrotor aircraft is described and includes a rotor system, a pylon coupled to the rotor system, a spindle coupled to the pylon, an actuator arm coupled to the spindle, and an actuator. The actuator can cause the actuator arm to rotate, thereby causing the spindle to rotate the pylon and the rotor system. In an example, the actuator is in front of a forward spar of the wing of the tiltrotor aircraft and the actuator arm is about one-half (0.5) of an inch to about five (5) inches from the wing.

Abstract: Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate oligonucleotides can have advantageous properties, for example in the form of defined multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced intracellular delivery and/or multi-gene silencing effects. In various embodiment, the defined multi-conjugate oligonucleotides can be synthesized via new synthetic intermediates and methods. The defined multi-conjugate oligonucleotides can be used, for example, in reducing gene expression, biological research, treating or preventing medical conditions, or to produce new or altered phenotypes in cells or organisms.

Abstract: A method of fabricating a panel includes laying up a first laminate on a tooling surface, laying a first layer of thermoplastic on an inner surface of the first laminate, laying a large cell carbon core on the first layer of thermoplastic, laying a second layer of thermoplastic across the large cell carbon core, laying a second laminate on the second layer of thermoplastic, creating a sealed core pocket by bonding the edges of the first and second layers of the thermoplastic surrounding a perimeter of the core, increasing pressure within the core pocket, increasing pressure on the outer surface of the second laminate, heating the panel to a desired curing temperature, and maintaining the increased pressures and temperature for a desired curing duration.

Abstract: A folding step system includes a housing forming an interior space and a step comprising a step surface. The step is movable between a stowed configuration in which substantially all of the step surface is disposed within the interior space and a deployed configuration in which at least a portion of the step surface is disposed outside of the interior space and at least a portion of the step surface is disposed within the interior space.

Abstract: An aircraft includes a fuselage having a former therein and a work platform system. The work platform system includes a platform that is moveable between a stowed configuration and a deployed configuration. The work platform system also has a hinge pin received by the platform. A platform stop is carried by the former and configured to inhibit rotation of the platform about the hinge pin when the platform is in the deployed configuration. The hinge pin is carried by the former.

Abstract: A tail rotor assembly coupled to a tailboom of a helicopter includes a tail rotor gearbox having top, bottom and aft sides and a shroud surrounding the tail rotor gearbox. The shroud includes a shroud airframe having top and bottom portions. The tail rotor assembly includes a tail rotor gearbox support assembly configured to support the tail rotor gearbox within the shroud. The tail rotor gearbox support assembly includes a support column coupling the aft side of the tail rotor gearbox between the top and bottom portions of the shroud airframe, an upper support crossbar coupling the top side of the tail rotor gearbox between the support column and the tailboom airframe and a lower support crossbar coupling the bottom side of the tail rotor gearbox between the support column and the tailboom airframe.

Abstract: A system for precision temperature control of thermal bead baths used in biological laboratories to heat biological samples. An insulated outer shell and an inner shell sealed together to form a recirculation pathway. The inner shell has an air extraction port opening into the recirculation pathway and at least one air injection port opening into the recirculation pathway. A fan in the recirculation pathway draws air through the air extraction port. A thermal sensor is connected to a control and is disposed in close proximity to one of the air injection ports. Thermal beads are placed in a mesh basket inside the inner shell. The fan draws air from the inner shell through the beads and into the recirculation pathway, where the air is heated by a thermal element. The air flows past the thermal element and through the air injection ports back into the inner shell.

Abstract: Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate oligonucleotides can have advantageous properties, for example in the form of defined multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced intracellular delivery and/or multi-gene silencing effects. In various embodiment, the defined multi-conjugate oligonucleotides can be synthesized via new synthetic intermediates and methods. The defined multi-conjugate oligonucleotides can be used, for example, in reducing gene expression, biological research, treating or preventing medical conditions, or t9o produce new or altered phenotypes in cells or organisms.

Abstract: Compositions for delivering nucleic acids to cells or tissue microenvironments are provided. In one embodiment, the compositions are lipid nanoparticle compositions formulated to have reduced splenic and hepatic clearance. It has been discovered that the chemical composition of lipid nanoparticles significantly influences the natural trafficking of the lipid nanoparticles. More specifically, it has been discovered that conformationally constrained ionizable lipids can modify the tropism and clearance profile of lipid nanoparticles without the need of a targeting ligand. It has also been discovered that tropism of the disclosed lipid nanoparticles is size-independent.

Abstract: Compositions and methods for inactivating RNA-guided genome editing systems in specific tissue, for example hepatocytes, are provided herein. In one embodiment, the compositions are small chemically modified oligonucleotides that can target and bind to guide RNA, thus eliminating the ability of guide RNA to interact with an endonuclease. The disclosed oligonucleotides are delivered in lipid nanoparticles formulated to target a specific tissue. Subsequently delivered RNA-guided genome editing systems will be inhibited in the specific tissue that received the oligonucleotides. The disclosed compositions and methods allow for reduced RNA-guided genome editing in hepatocytes.

Abstract: One embodiment includes a rotary aircraft, including: a rotary propulsion system; a body; and a pair of wings connected on opposite sides of the body, wherein each of the wings includes a flap rotatably connected to a trailing edge thereof and configured to rotate downward relative to the wing during low speed and stationary flight of the aircraft, and to rotate upward relative to the wing during high-speed flight of the aircraft.

Abstract: A system is described and includes a rack for carrying payload disposed in payload bay; a rack extension assembly for affecting linear displacement of the rack between a first position in which the rack is stowed within the payload bay and a second position in which the rack is supported outside the payload bay; a payload actuator system for selectively causing the rack extension assembly to move the rack between the first and second positions; a payload bay door; and a door actuator system for selectively opening and closing the payload bay door.

Abstract: Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate oligonucleotides can have advantageous properties, for example in the form of defined multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced intracellular delivery and/or multi-gene silencing effects. In various embodiment, the defined multi-conjugate oligonucleotides can be synthesized via new synthetic intermediates and methods. The defined multi-conjugate oligonucleotides can be used, for example, in reducing gene expression, biological research, treating or preventing medical conditions, or to produce new or altered phenotypes in cells or organisms.

Abstract: A system to process navigation information includes a receiving module to receive a data request from a network entity. The data request includes a network entity identifier that uniquely identifies the network entity. The system further includes an application to generate a network event based on the data request, the network event including the navigation information. Finally, the system includes a publisher module to communicate the network event to a first server that is distinguished from a first plurality of servers based on the network entity identifier.

Abstract: A system is described and includes a rack for carrying payload disposed in a payload bay; and a payload extension assembly for affecting linear translation of the rack between a first position in which the rack is fully retracted within the payload bay and a second position in which the payload extension assembly is fully extended and the rack is supported outside the payload bay. The payload extension assembly comprises forward and aft tracks respectively attached to forward and aft walls of the payload bay; a first stage for providing linear translation of the rack relative to the forward and aft tracks; and a second stage for providing linear translation of the rack relative to the first stage. The system further comprises a payload actuator system for selectively causing the rack extension assembly to move the rack between the first and second positions.

Abstract: One example of a tiltrotor aircraft includes a rotor system, a pylon coupled to the rotor system, a spindle coupled to the pylon, an actuator arm coupled to the spindle, and an actuator. The actuator can cause the actuator arm to rotate, thereby causing the spindle to rotate the pylon and the rotor system. In an example, the actuator is in front of a forward spar of the wing of the tiltrotor aircraft and the actuator arm is about one-half (0.5) of an inch to about five (5) inches from the wing.

Abstract: One embodiment includes a rotary aircraft, including: a rotary propulsion system; a body; and a pair of wings connected on opposite sides of the body, wherein each of the wings includes a flap rotatably connected to a trailing edge thereof and configured to rotate downward relative to the wing during low speed and stationary flight of the aircraft, and to rotate upward relative to the wing during high-speed flight of the aircraft.