Patents by Inventor James Gammie
James Gammie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240033082Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
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Patent number: 11872133Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.Type: GrantFiled: July 29, 2022Date of Patent: January 16, 2024Assignee: University of Maryland, Baltimore; University of Maryland Medical System LLCInventors: James Gammie, Rachael Quinn, Chetan Pasrija
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Publication number: 20220395371Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.Type: ApplicationFiled: January 25, 2022Publication date: December 15, 2022Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
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Publication number: 20220273431Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.Type: ApplicationFiled: January 25, 2022Publication date: September 1, 2022Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
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Patent number: 11259925Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.Type: GrantFiled: May 29, 2020Date of Patent: March 1, 2022Assignees: University of Maryland, Baltimore, University of Maryland Medical System LLCInventors: James Gammie, Rachael Quinn, Chetan Pasrija
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Publication number: 20200345495Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.Type: ApplicationFiled: May 29, 2020Publication date: November 5, 2020Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
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Publication number: 20200306043Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treats mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.Type: ApplicationFiled: November 5, 2018Publication date: October 1, 2020Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
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Patent number: 10639024Abstract: Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used during a procedure to repair a mitral valve. In some embodiments, an implant securing device includes an outer member and an inner member movably disposed within the outer member. The inner member can be used to hold or secure a suture extending from an implant deployed on an atrial side of a leaflet of a mitral valve, and the outer member can be used to push or move a half hitch knot toward a ventricular side of the leaflet, which can be used to secure the implant in the desired position.Type: GrantFiled: May 26, 2017Date of Patent: May 5, 2020Assignees: University of Maryland, Baltimore, Harpoon Medical, Inc.Inventors: James Gammie, Peter Wilson, Peter Boyd, William Niland
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Patent number: 10285686Abstract: Methods and devices for repairing a cardiac valve. A minimally invasive procedure includes creating an access in the apex region of the heart through which one or more instruments may be inserted. The device can implant artificial heart valve chordae tendineae into cardiac valve leaflet tissues to restore proper leaflet function and prevent reperfusion. The device punctures the apex of the heart and travels through the ventricle. The tip of the device rests on the defective valve and punctures the valve leaflet. A suture or a suture/guide wire combination is inserted, securing the top of the leaflet to the apex of the heart. A resilient element or shock absorber mechanism adjacent to the outside of the apex of the heart minimizes the linear travel of the device in response to the beating of the heart or opening/closing of the valve.Type: GrantFiled: September 5, 2014Date of Patent: May 14, 2019Assignee: University of Maryland, BaltimoreInventors: James Gammie, Rahul Patel, Mehrdad Ghoreishi
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Publication number: 20170258464Abstract: Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used during a procedure to repair a mitral valve. In some embodiments, an implant securing device includes an outer member and an inner member movably disposed within the outer member. The inner member can be used to hold or secure a suture extending from an implant deployed on an atrial side of a leaflet of a mitral valve, and the outer member can be used to push or move a half hitch knot toward a ventricular side of the leaflet, which can be used to secure the implant in the desired position.Type: ApplicationFiled: May 26, 2017Publication date: September 14, 2017Applicants: Harpoon Medical, Inc., University of Maryland, BaltimoreInventors: James GAMMIE, Peter WILSON, Peter BOYD, William NILAND
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Patent number: 9681864Abstract: Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used during a procedure to repair a mitral valve. In some embodiments, an implant securing device includes an outer member and an inner member movably disposed within the outer member. The inner member can be used to hold or secure a suture extending from an implant deployed on an atrial side of a leaflet of a mitral valve, and the outer member can be used to push or move a half hitch knot toward a ventricular side of the leaflet, which can be used to secure the implant in the desired position.Type: GrantFiled: December 29, 2014Date of Patent: June 20, 2017Assignees: Harpoon Medical, Inc., University of Maryland, BaltimoreInventors: James Gammie, Peter Wilson, Peter Boyd, William Niland
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Publication number: 20150032127Abstract: Methods and devices for repairing a cardiac valve. A minimally invasive procedure includes creating an access in the apex region of the heart through which one or more instruments may be inserted. The device can implant artificial heart valve chordae tendineae into cardiac valve leaflet tissues to restore proper leaflet function and prevent reperfusion. The device punctures the apex of the heart and travels through the ventricle. The tip of the device rests on the defective valve and punctures the valve leaflet. A suture or a suture/guide wire combination is inserted, securing the top of the leaflet to the apex of the heart. A resilient element or shock absorber mechanism adjacent to the outside of the apex of the heart minimizes the linear travel of the device in response to the beating of the heart or opening/closing of the valve.Type: ApplicationFiled: September 5, 2014Publication date: January 29, 2015Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: James Gammie, Rahul Patel, Mehrdad Ghoreishi
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Patent number: 8852213Abstract: Methods and devices for repairing a cardiac valve. A minimally invasive procedure includes creating an access in the apex region of the heart through which one or more instruments may be inserted. The device can implant artificial heart valve chordae tendineae into cardiac valve leaflet tissues to restore proper leaflet function and prevent reperfusion. The device punctures the apex of the heart and travels through the ventricle. The tip of the device rests on the defective valve and punctures the valve leaflet. A suture or a suture/guide wire combination is inserted, securing the top of the leaflet to the apex of the heart. A resilient element or shock absorber mechanism adjacent to the outside of the apex of the heart minimizes the linear travel of the device in response to the beating of the heart or opening/closing of the valve.Type: GrantFiled: December 23, 2013Date of Patent: October 7, 2014Assignee: University of Maryland, BaltimoreInventors: James Gammie, Rahul Patel, Mehrdad Ghoreishi
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Publication number: 20140114404Abstract: Methods and devices for repairing a cardiac valve. A minimally invasive procedure includes creating an access in the apex region of the heart through which one or more instruments may be inserted. The device can implant artificial heart valve chordae tendineae into cardiac valve leaflet tissues to restore proper leaflet function and prevent reperfusion. The device punctures the apex of the heart and travels through the ventricle. The tip of the device rests on the defective valve and punctures the valve leaflet. A suture or a suture/guide wire combination is inserted, securing the top of the leaflet to the apex of the heart. A resilient element or shock absorber mechanism adjacent to the outside of the apex of the heart minimizes the linear travel of the device in response to the beating of the heart or opening/closing of the valve.Type: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: James Gammie, Rahul Patel, Mehrdad Ghoreishi
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Patent number: 7740627Abstract: The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.Type: GrantFiled: January 6, 2006Date of Patent: June 22, 2010Assignee: Medtronic Cryocath LPInventors: James Gammie, Randy Jordan, Marwan Abboud, Allan Zingeler, Saqib Masroor
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Publication number: 20080243111Abstract: The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.Type: ApplicationFiled: January 6, 2006Publication date: October 2, 2008Inventors: James Gammie, Randy Jordan, Marwan Abboud, Allan Zingeler, Saqib Masroor
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Publication number: 20070265643Abstract: The present invention relates to an apparatus and method for securing a connector conduit to a hollow organ. The method comprises forming a hole in a wall of the organ; inserting a connector conduit through the hole in the wall of the organ until a flange element comes into contact with the wall of the organ, the flange element being positioned on the connector conduit; and engaging a retention means with the wall of the organ to prevent movement of the connector conduit relative to the wall of the organ, the retention means being positioned on the connector conduit. Exemplary retaining means include a plurality of retaining pins positioned circumferentially around the connector conduit, a plurality of prongs positioned circumferentially around the connector conduit, a balloon positioned on the connector conduit, a torsion spring positioned on the connector conduit, a spiral spring positioned on the connector conduit, or combinations thereof.Type: ApplicationFiled: April 6, 2007Publication date: November 15, 2007Inventors: Richard Beane, John Brown, James Crunkleton, James Gammie, Joseph Smith
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Publication number: 20070088375Abstract: The invention relates to an apparatus and method for forming a hole in a wall of a hollow organ. The applicator includes a hole forming element for forming a hole in the wall of the organ, a positioning means for positioning the hole forming element, and a retractor element. In addition, the applicator includes a sequencing means for coordinating the relative movement of the retractor element and the hole forming element in a sequential manner to thereby carry out a procedure for forming a hole in the wall of the hollow organ. The sequencing means may further include a safety latch element operatively coupled to the retracting means and the hole forming element. The safety latch of the invention keeps prevents damage to the internal surface of the organ during the formation of the hole.Type: ApplicationFiled: October 16, 2006Publication date: April 19, 2007Applicant: CORREX, INC.Inventors: Richard Beane, John Brown, James Crunkleton, James Gammie, Joseph Smith
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Publication number: 20060161193Abstract: The present invention provides a system and method for forming a side branch on a hollow vessel, such as the aorta. The side branch is preferably adapted to be connected to a connector conduit, but any other suitable use is also acceptable. The system comprises a graft including a side branch portion, and an applicator comprising a hole forming element adapted to form a hole in the wall of the vessel and an insertion element adapted to be inserted through the wall of the vessel, the insertion element comprising a retraction element adapted to enter into engagement with the graft. The hole forming element may comprise a cutting element adapted to cut a hole in the wall of the vessel, and a positioning element adapted to hold the position of the applicator relative to the vessel. The system further comprises a graft protection element adapted to prevent the graft from being damaged by the cutting element.Type: ApplicationFiled: December 15, 2005Publication date: July 20, 2006Applicant: Correx, Inc.Inventors: Richard Beane, John Brown, James Crunkleton, James Gammie, Joseph Smith
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Publication number: 20050251187Abstract: An apparatus and method for connecting a first conduit to the heart without the need for cardiopulmonary bypass. The first conduit may then be attached to a second conduit that has a prosthetic device interposed. The second conduit may be connected to the aorta prior to the first conduit being attached to the heart. The prosthetic device may be a prosthetic valve or a pump, for example. The apparatus of the present invention includes an implantable connector with first conduit component, a retractor expansion component, a coring component, and a pushing component. The retractor expansion component is slide-ably coupled to the coring component. The retractor expansion component serves to seat against and separate the inside apical wall of the left ventricle so that the coring component may cut cleanly through the myocardium to form a tissue plug without leaving any hanging attachments to the inside walls.Type: ApplicationFiled: March 23, 2005Publication date: November 10, 2005Applicant: Correx, Inc.Inventors: Richard Beane, John Brown, James Crunkleton, James Gammie, Joseph Smith