Abstract: A method of optimizing pharmacotherapy includes monitoring one or more characteristics of a patient associated with a condition of the patient and evaluating a baseline severity of the condition of the patient, recommending a selected therapy to the patient based on a therapy efficacy-risk map, evaluating an actual severity of the condition of the patient, evaluating an efficacy of the selected therapy, evaluating a risk score of the selected therapy, and updating the therapy efficacy-risk map based on the evaluated efficacy and risk score of the selected therapy.

Abstract: Systems (100) and methods (300) for controlling coughing by subjects (106) control the opening and closing of a valve (12) (as well as partially opening and/or partially closing) to establish and disestablish a fluid communication between the airway of the subject and atmospheric pressure. The valve is opened and closed more than once during individual exhalations by the subject. Control of the valve is adjusted based on a pressure level in or near the airway of the subject.

Abstract: The present system (10) comprises a subject interface (22), a segmenter (12), a loosener (14), sensors (18), and computer processors (28). The segmenter is configured to selectively control gas flow through the subject interface to provide high amplitude pressure oscillations (44) during exhalation such that the high amplitude pressure oscillations aid cough productivity in the subject. The loosener controls gas flow through the subject interface to provide low amplitude pressure oscillations (43, 63) during inhalation (48, 68) and exhalation (49) such that the low amplitude pressure oscillations loosen respiratory secretions.

Abstract: Systems (100) and methods (300) for controlling coughing by subjects (106) control the opening and closing of a valve (12) (as well as partially opening and/or partially closing) to establish and disestablish a fluid communication between the airway of the subject and atmospheric pressure. The valve is opened and closed more than once during individual exhalations by the subject. Control of the valve is adjusted based on a pressure level in or near the airway of the subject.

Abstract: The present system (10) comprises a subject interface (22), a segmenter (12), a loosener (14), sensors (18), and computer processors (28). The segmenter is configured to selectively control gas flow through the subject interface to provide high amplitude pressure oscillations (44) during exhalation such that the high amplitude pressure oscillations aid cough productivity in the subject. The loosener controls gas flow through the subject interface to provide low amplitude pressure oscillations (43, 63) during inhalation (48, 68) and exhalation (49) such that the low amplitude pressure oscillations loosen respiratory secretions.