Abstract: Pharmacologically active implants, in particular subcutaneous implants, intrauterine devices, and intravaginal rings, are provided herein. Methods for forming an active ingredient-containing core are described. Methods for laminating an active ingredient-containing core to form a rate-controlling sheath are also described.

Abstract: Pharmacologically active implants, in particular subcutaneous implants, intrauterine devices, and intravaginal rings, are provided herein. Methods for forming an active ingredient-containing core are described. Methods for laminating an active ingredient-containing core to form a rate-controlling sheath are also described.

Abstract: The invention provides methods for making silicone structures, drug delivery devices and active pharmaceutical agent delivery systems and medical devices containing one or more active pharmaceutical ingredients. The invention provides silicone structures, drug delivery devices and active pharmaceutical agent delivery systems containing one or more active pharmaceutical ingredients. The silicones used in the invention are foaming silicones, which generate void-forming gases which completely volatilize during curing. The silicone structures, drug delivery devices and active pharmaceutical agent delivery systems can be of any shape or size, and are porous, and are capable of being loaded with high doses of the desired drug or drugs. The active pharmaceutical ingredients can be incorporated into the silicone prior to curing, or subsequent to curing, via a soaking process.

Abstract: The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.

Abstract: Pharmacologically active implants, in particular subcutaneous implants, intrauterine devices, and intravaginal rings, are provided herein. Methods for forming an active ingredient-containing core are described. Methods for laminating an active ingredient-containing core to form a rate-controlling sheath are also described.

Abstract: The present invention relates to nanostructured material capable of storing hydrogen. The nanostructured material may be configured with a selected geometry to provide the capability to influence and increase the limiting or theoretical gravimetric storage level (GSL) of hydrogen for a given chemical composition.

Abstract: The present invention is directed to a composite particle that is microscopically two-dimensional with a third nanoscopic dimension, and to methods of making same. The particle may include a support and a metal layer. The metal layer may be catalytically active such that the particle is adapted to act as a catalyst.

Abstract: The present invention is directed to a composite particle that is microscopically two-dimensional with a third nanoscopic dimension, and to methods of making same. The particle may include a support and a metal layer. The metal layer may be catalytically active such that the particle is adapted to act as a catalyst.

Abstract: The present disclosure relates to a coating and a method of applying such coating that may include nanocrystals of a transition metal compound embedded in an amorphous phase or layered structure of transition metal compounds with an amorphous phase. The transition metal compound may be selected from the group consisting of metal nitrides, metal carbides, metal silicides and combinations thereof. The amorphous matrix may include a ceramic.

Abstract: The present disclosure relates to a method for plasma ion deposition and coating formation. A vacuum chamber may be supplied, wherein the vacuum chamber is formed by a hollow substrate having a length, diameter and interior surface. A plasma may be formed within the chamber while applying a negative bias to the hollow substrate to draw ions from the plasma to the interior surface of the hollow substrate to deposit ions onto the interior surface and forming a coating. The coating may have a Vickers Hardness Number (Hv) of at least 500.

Abstract: The present invention is directed to a composite particle that is microscopically two-dimensional with a third nanoscopic dimension, and to methods of making same. The particle may include a support and a metal layer. The metal layer may be catalytically active such that the particle is adapted to act as a catalyst.

Abstract: Embodiments of the invention include biodegradable composites and medical devices including the same. In an embodiment the invention includes a biodegradable implantable medical device. The implantable medical device can include a biodegradable composite member including a polymeric matrix and a reinforcing metal disposed within the polymeric matrix. The biodegradable composite member can be configured to erode in vivo. In an embodiment the invention includes a method of making a biodegradable implantable device including contacting a polymer mixture with a reinforcing metal, the polymer mixture comprising a polymer that degrades under in vivo conditions and the reinforcing metal comprising a metal that produces substantially non-toxic erosion products. Other embodiments are included herein.

Abstract: An electrically conductive coating composition that includes a polymeric mixture, an electrically conductive material dispersed within the polymeric mixture and, optionally, one or more bioactive agents is described.

Abstract: The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.

Abstract: This invention is directed to a method of preventing oxidation of copper alloys at high temperatures by deposition of a nano-structured, low-chromium copper-chromium protective coating to copper-alloy components. The coatings of the present invention are applied by an ion beam assisted, electron beam physical vapor deposition and consist of copper and chromium particles having a diameter of about 10 nm. This invention also encompasses the coated copper-alloy components produced by the disclosed deposition methods.

Abstract: The invention relates to porous drug delivery devices and related methods. In an embodiment, the invention includes an active agent delivery system including a reservoir body defining a plurality of interconnected pores, an active agent disposed within the interconnected pores, and a first polymeric layer disposed over the reservoir body. In an embodiment, the invention includes an implantable medical device including a porous substrate defining a plurality of interconnected pores, an active agent disposed within the interconnected pores, and a first polymeric layer disposed over the reservoir body. In an embodiment, the invention includes a method of making an active agent delivery system including forming a porous reservoir body, inserting an active agent within the porous reservoir body, and applying a polymeric layer over the porous reservoir body. Other embodiments are also included herein.

Abstract: The present disclosure relates to an apparatus and method for plasma ion deposition and coating formation. A vacuum chamber may be supplied formed by a hollow substrate having a length, diameter and interior surface. A plasma may be formed within the chamber while applying a negative bias to the hollow substrate to draw ions from the plasma to the interior surface of the hollow substrate to deposit ions onto the interior surface and forming a coating. The coating may have a Vickers Hardness Number (Hv) of at least 500.

Abstract: The present invention is directed to a composite particle that is microscopically two-dimensional with a third nanoscopic dimension, and to methods of making same. The particle may include a support and a metal layer. The metal layer may be catalytically active such that the particle is adapted to act as a catalyst.

Abstract: The present invention relates to nanostructured material capable of storing hydrogen. The nanostructured material may be configured with a selected geometry to provide the capability to influence and increase the limiting or theoretical gravimetric storage level (GSL) of hydrogen for a given chemical composition.

Abstract: Glass having a diamond-like carbon (DLC) coating on top of an intermediate bonding layer of tin oxide, and a method for producing same. A glow-discharge method is used to apply the DLC coating. The glass may be chemically strengthened prior to applying the DLC coating.