Abstract: A cardiomyocyte maturation medium comprises a base medium, one or more fatty acids such as palmitic acid, glucose and albumin. The one or more fatty acids and glucose are ideally present at a concentration ratio of about 1:10. Typically, the medium does not comprise TGF or insulin, or comprises minimal TGF and/or insulin. A cell culture vessel is provided that comprises opposed poles that facilitate force measurements of developing cardiac muscle.

Abstract: Methods and systems to control continuous gas fermentation platforms for improved conversion of gas substrates into products is developed and particularly relates to a control process and system to control feedstock gases and maximize the bioreactor performance with biomarkers. Improved carbon utilization results through providing the most beneficial feed of substrates to the bioreactor of the fermentation process.

Abstract: Apparatus and methods automate selection of patient interface(s) according to their size, such as with processing in a processor(s) or in a server(s). Image data captured by an image sensor may be received. The captured image data may contain facial feature(s) of an intended user of the patient interface. The facial features may be captured in association with a predetermined reference feature of known dimension(s). The user's facial feature(s) and the reference feature may be detected in the captured image data. Image pixel data of the image may be processed to measure an aspect of the detected facial feature(s) based on the reference feature. A patient interface size may be detected from standard patient interface sizes based on a comparison between the measured aspect of the facial feature(s) and a data record relating sizing information of the standard patient interface sizes and the measured aspect of the facial feature(s).

Abstract: A joining assembly (12) comprises two joining devices (10). Each joining device (10) comprises a securing arrangement (46) for securing at least one article (14) to the joining devices (10). One of the joining devices (10) comprises a first attaching arrangement (30, 32), and the other of the joining devices (10) comprises a second attaching arrangement (30, 32). The first and second attaching arrangements can cooperate with each other to attach the joining devices (10) to each other.

Abstract: System and method for updating customer data that includes a plurality of electronically stored contact records that each include contact information for a respective individual contact. Filtering is applied to the customer data to identify contacts that fall within defined filtering criteria. Information about the identified contacts is provided to a decision making authority for a further layer of filtering. Customer data is updated based on feedback derived from the decision making authority.

Abstract: A position sensing device for sensing an upper limit position and a lower limit position of a hoisting line for raising and lowering a door leaf of an animal enclosure, the position sensing device comprising a hoisting line pathway for a hoisting line to raise and lower a door leaf of an animal enclosure, an actuator arm moveable between a first position and a second position, and a proximity switch having a first state corresponding to the actuator arm being in the first position and a second state corresponding to the actuator arm being in the second position.

Abstract: In one aspect, a method of making an audio recording in a recording session comprises sending a first audio packet from a first device to a second device, the first audio packet comprising a portion of a first audio signal for playback at the second device; receiving at the first device a second audio packet from the second device, the second audio packet comprising a portion of a second audio signal, the second audio signal being created at the second device during playback of the first audio signal by the second device; delaying the second audio packet by an first adjustment latency, wherein the first adjustment latency is set so that a total delay between the first audio packet sent by the first device and the second audio packet received by the first device from the second device equals a fixed audio packet delay for the recording session.

Abstract: The present invention provides a new method for producing Engineered Heart Muscle (EHM) under chemically fully defined conditions all compatible with GMP regulations. The resulting human myocardium generates force and shows typical heart muscle properties.

Abstract: An insulated electric cord (102) comprises an elongate covering arrangement (12) and at least two elongate electrical conductors (14, 16) held within the covering arrangement (12). The insulated electric cord (102) further comprises an elongate load bearing member (20) held within the covering arrangement (12). The insulated electric cord (102) further comprises an elongate flexible cutting member (22) held within the covering arrangement (12). The elongate electrical conductors (14, 16), the elongate load bearing member (20), and the elongate flexible cutting member (22) extend longitudinally through the covering arrangement (12). The elongate flexible cutting member (22) extends through the covering arrangement (12) adjacent the elongate load bearing member (20). The cutting member (22) is capable of cutting the covering arrangement (12), thereby allowing a portion of the load bearing member (20) to be extracted from the covering arrangement (12).

Abstract: Provided herein are in vitro and in vivo methods of inducing cardiomyocyte proliferation by contacting cardiomyocytes with or administering to a subject an effective amount of an agent capable of activating sterol biosynthesis, such as mevalonate biosynthesis. Methods and compositions for regenerating a cardiac tissue in a subject that include administering thereto a therapeutically effective amount of an agent capable of activating sterol biosynthesis in a cardiomyocyte are also provided herein.

Abstract: Apparatus and methods automate selection of patient interface(s) according to their size, such as with processing in a processor(s) or in a server(s). Image data captured by an image sensor may be received. The captured image data may contain facial feature(s) of an intended user of the patient interface. The facial features may be captured in association with a predetermined reference feature of known dimension(s). The user's facial feature(s) and the reference feature may be detected in the captured image data. Image pixel data of the image may be processed to measure an aspect of the detected facial feature(s) based on the reference feature. A patient interface size may be detected from standard patient interface sizes based on a comparison between the measured aspect of the facial feature(s) and a data record relating sizing information of the standard patient interface sizes and the measured aspect of the facial feature(s).

Abstract: Disclosed is a method and system for modifying content stored in a blockchain. The method comprises identifying an old block of the blockchain comprising undesired data in a transaction of the old block. An updated block may be created by correcting the transaction of the old block. A new block hash may be determined for the updated block. Corrected form of the transaction may be submitted, as a new transaction, along with the new block hash and the difference between the new block hash and hash of the old block. Miners may be allowed to mine the corrected form of the transaction, along with other new transactions. The other new transactions may be mined, based on a consensus of users of the blockchain, into a new block connected to a tip of the blockchain, and the old block may be edited to introduce the corrected form of the transaction.

Abstract: Apparatus and methods automate selection of patient interface(s) according to their size, such as with processing in a processor(s) or in a server(s). Image data captured by an image sensor may be received. The captured image data may contain facial feature(s) of an intended user of the patient interface. The facial features may be captured in association with a predetermined reference feature of known dimension(s). The user's facial feature(s) and the reference feature may be detected in the captured image data. Image pixel data of the image may be processed to measure an aspect of the detected facial feature(s) based on the reference feature. A patient interface size may be detected from standard patient interface sizes based on a comparison between the measured aspect of the facial feature(s) and a data record relating sizing information of the standard patient interface sizes and the measured aspect of the facial feature(s).

Abstract: A method and kit for detecting at least two vitamin D metabolites in a biological sample is disclosed, which comprises processing the biological sample to prepare the sample for LC-MS/MS analysis, passing the prepared sample through a liquid chromatography column having an outlet connected to an inlet port of a tandem mass spectrometer to separate said two vitamin D metabolites, if present in the sample, and introduce the two vitamin D metabolites into the tandem mass spectrometer. The method further comprises generating [M+H]+ ions of each of the two vitamin D metabolites in said tandem mass spectrometer, and generating two fragment ions of said [M+H]+ ions associated with said vitamin D metabolites, wherein said fragment ions are not due to water losses from the [M+H]+ ions; and detecting the fragment ions to identify presence of the two metabolites in the biological sample.

Abstract: System and method for updating customer data that includes a plurality of electronically stored contact records that each include contact information for a respective individual contact. Filtering is applied to the customer data to identify contacts that fall within defined filtering criteria. Information about the identified contacts is provided to a decision making authority for a further layer of filtering. Customer data is updated based on feedback derived from the decision making authority.

Abstract: Disclosed is a method and system for debugging source code of an application. The method includes establishing a WebSocket connection with a Chrome DevTools Protocol, using a unique Uniform Resource Locator (URL) created by Node.js. The Chrome DevTools Protocol is a V8 inspector. The method further includes listening for asynchronous messages from the V8 inspector. The asynchronous messages are defined by V8 inspector protocol. Responses received from the V8 inspector protocol are processed and debugger operations selected by a user are translated into operations known to the V8 inspector. The source code of the application is executed on the Node.js utilizing launch configuration and data required for starting a Node.js process with responsibilities of terminating the Node.js process when the user ends the debug session.

Abstract: There are described plants of Papaver somniferum having reduced expression or activity of magnesium chelatase where-by the plants yield poppy straw having an altered alkaloid profile. In embodiments of the plants the reduced expression or activity of magnesium chelatase is associated with a trait for a lightened leaf colour. There are also described methods for producing the plants, and poppy straw, latex, concentrate of poppy straw and opium from the plants.