Abstract: A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor antagonist and a therapeutically-effective amount of expoxymexrenone.

Abstract: A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist. Preferred angiotensin II receptor antagonists are those compounds having high potency and bioavailability and which are characterized in having an imidazole or triazole moiety attached to a biphenylmethyl or pyridinyl/phenylmethyl moiety. Preferred epoxy-steroidal aldosterone receptor antagonists are 20-spiroxane steroidal compounds characterized by the presence of a 9&agr;, 11&agr;-substituted epoxy moiety. A preferred combination therapy includes the angiotensin II receptor antagonist 5-[2-[5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-pyridinyl]phenyl-1H-tetrazole and the aldosterone receptor antagonist epoxymexrenone.

Abstract: Methods and compositions for the protection of white matter of the central nervous system. Specifically, the use of IGF-I, its analogs and mimetics, and the use of IGF-I, its analogs and mimetics in combination with interferons including beta 1 and consensus interferons, to stimulate glial cells such as mature astrocytes to promote remyelination to treat neuronal disease and injury, such as result from, for example, hypoxia, ischemia, trauma, degenerative and demyelinating diseases.

Abstract: A fluid (12), such as dichlorosilane, is stored in a pressure vessel (17) located at a site remote from a processing facility within the confines of a building (14). At such remote site the pressure vessel (17) is subject to climatic temperature variations over a range at the lower temperatures of which a vapor pressure of the fluid may be insufficient to generate a pressure within the pressure vessel to drive the fluid through a duct (36) toward the processing facility. A supply of an inert gas (34) is applied at a first predetermined pressure to the pressure vessel (17) to urge the fluid under such predetermined pressure through the duct (36) toward an evaporator vessel (38) located at the processing facility. The evaporator vessel (38) is maintained at a first predetermined elevated temperature at which the fluid at such first predetermined pressure is in a gaseous state.

Abstract: An array of discrete semiconductor devices is formed by photoresist and etching techniques in a semiconductor wafer waxed to a support. The photoresist material is then removed and the devices are tested. Next, a substrate is coated with silicone resin to which the devices will adhere. The devices found from the test to have a first characteristic are transferred to the resin-coated substrate to form a new array of first characteristic semiconductor devices with the original orientation. The devices are pressed against the resin by means of a polytetrafluoroethylene screen overlaid with a stainless steel screen and trichlorethylene is flowed through the screens to the devices to remove any remanent wax. When the screens are removed the devices do not stick to the polytetrafluorethylene screen, which had been against them, but remain held on the resin coated substrate in their originally oriented array.