Patents by Inventor James J. Fischer

James J. Fischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRas G12D inhibitors
    Patent number: 11964989
    Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: April 23, 2024
    Assignees: Mirati Therapeutics, Inc., Array BioPharma Inc.
    Inventors: Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson, Matthew Arnold Marx, Christopher Ronald Smith, Shelley Allen, James F. Blake, Mark Joseph Chicarelli, Joshua Ryan Dahlke, Donghua Dai, Jay Bradford Fell, John Peter Fischer, Macedonio J. Mejia, Brad Newhouse, Phong Nguyen, Jacob Matthew O'Leary, Spencer Pajk, Martha E. Rodriguez, Pavel Savechenkov, Tony P. Tang, Guy P.A. Vigers, Qian Zhao, Dean Russell Kahn, John Gaudino, Michael Christopher Hilton
  • PROTEIN TYROSINE PHOSPHATASE INHIBITORS
    Publication number: 20240124453
    Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
    Type: Application
    Filed: November 17, 2023
    Publication date: April 18, 2024
    Applicant: Array BioPharma Inc.
    Inventors: James Francis BLAKE, Mark Laurence BOYS, Mark Joseph CHICARELLI, Adam Wade COOK, Mohamed S. A. ELSAYED, Jay Bradford FELL, John P. FISCHER, Ronald Jay HINKLIN, Yutong JIANG, Oren Teague MCNULTY, Macedonio J. MEJIA, Martha E. RODRIGUEZ, Christina Elizabeth WONG
  • KRAS G12C INHIBITORS
    Publication number: 20240101553
    Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
    Type: Application
    Filed: August 4, 2023
    Publication date: March 28, 2024
    Inventors: Matthew Arnold MARX, James Gail CHRISTENSEN, Christopher Ronald SMITH, James F. BLAKE, Laurence E. BURGESS, Mark Joseph CHICARELLI, Adam COOK, Jay Bradford FELL, John P. FISCHER, Macedonio J. MEJIA, Martha E. RODRIGUEZ, Pavel SAVECHENKOV, Tony P. TANG, Guy P.A. VIGERS
  • KRas G12C inhibitors
    Patent number: 11932633
    Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: March 19, 2024
    Assignees: Mirati Therapeutics, Inc., Array Biopharma Inc.
    Inventors: Matthew Arnold Marx, Matthew Randolph Lee, James F. Blake, Mark Joseph Chicarelli, Jay Bradford Fell, John P. Fischer, Erik James Hicken, Pavel Savechenkov, Tony Tang, Guy P. A. Vigers, Henry J. Zecca
  • Power ring adapter assembly
    Patent number: 6453894
    Abstract: An adapter for retrofitting to a stock engine for use in performance racing. The adapter is fitted between a stock air filter and a stock throttle or carburetor and provides a safe and secure mounting point for nitrous oxide/fuel injection nozzles or spray bars. Two embodiments are disclosed: the first for use directly between the air filter and the throttle body or carburetor and the second for installation using standard air hoses.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: September 24, 2002
    Inventors: James J. Fischer, James Jureski
  • Spray bar pair assembly
    Patent number: 6279557
    Abstract: A spray bar pair for use in the performance car industry is disclosed. The spray bar pair may be installed in a spray bar plate for mounting in the air flow from the throttle valve and injects a well mixed mixture of fuel and gas into the intake manifold of an engine. The spray bar pair utilizes carefully a chosen pattern of spray apertures set at such angles in the spray bar pair to ensure proper mixing. Several methods of use for the improved spray bar pair are given.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: August 28, 2001
    Assignee: Specialty Motorsports, Inc.
    Inventors: James J. Fischer, James Jureski
  • Method for increasing tissue oxygenation using fish hemoglobin exhibiting a root effect
    Patent number: 5770560
    Abstract: The invention relates to the use of fish hemoglobins that exhibit a Root effect to increase tissue oxygenation in patients suffering from disease states associated with compromised oxygen delivery to tissues.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 23, 1998
    Assignee: James J. Fischer
    Inventors: James J. Fischer, Susan J. Baserga
  • Genetically engineered low oxygen affinity mutants of human hemoglobin
    Patent number: 5428007
    Abstract: Peptides encoded by a substantially pure polynucleotide coding for an alpha and/or beta human globin, the globin when part of a hemoglobin molecule conferring lower oxygen affinity than normal hemoglobin to result in a mutant hemoglobin, the mutant hemoglobin having an oxygen affinity measured for stripped hemoglobin characterized by a P.sub.50 of 30 torr to 3 atmospheres and/or by a Hill coefficient between 2.5 and 1.0. Such mutant hemoglobin being useful to increase tissue oxygenation in a patient, to replace hemoglobin in the bloodstream of a patient and to treat patients suffering from burns.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: June 27, 1995
    Assignee: Yale University
    Inventors: James J. Fischer, Susan J. Baserga
  • DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
    Patent number: 5173426
    Abstract: A substantially pure polynucleotide coding for an alpha and/or beta human globin, the globin when part of a hemoglobin molecule confering lower oxygen affinity than normal hemoglobin to result in a mutant hemoglobin, the mutant hemoglobin having an oxygen affinity measured for stripped hemoglobin characterized by a P.sub.50 of 30 torr to 3 atmospheres and/or by a Hill coefficient between 2.5 and 1.0. Such mutant hemoglobin being useful to increase tissue oxygenation in a patient, to replace hemoglobin in the bloodstream of a patient and to treat patients suffering from burns.
    Type: Grant
    Filed: October 6, 1989
    Date of Patent: December 22, 1992
    Assignee: Yale University
    Inventors: James J. Fischer, Susan J. Baserga
  • Gas-fuel nozzle
    Patent number: D420364
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: February 8, 2000
    Assignee: Specialty Motorsports Inc.
    Inventors: James J. Fischer, James Jureski