Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: Disclosed herein is a method for scrub-free cleaning of a soiled solid surface. Additionally disclosed herein is a method of using a cleaning composition for scrub-free cleaning of a soiled solid surface. Further disclosed herein is a unit dose article including the cleaning composition.

Abstract: The invention provides uses of autophagocytosis inducing compounds for reducing serum levels of triglycerides and VLDL and the preparation of medicaments. The invention also provides the use of autophagocytosis inducing compounds for treating hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, hyperlipoproteinemia, atherosclerosis, arteriosclerosis, peripheral artery disease, coronary artery disease, congestive heart failure, myocardial ischemia, myocardial infarction, ischemic stroke, hemorrhagic stroke, or diabetes, insulin resistance, hemodialysis, glycogen storage disease type I, polycystic ovary syndrome, combination thereof. The invention further provides methods of identifying compounds which modulate autophagocytosis.

Abstract: Combined laser-based apparatus for determining both altitude and ground velocity of an aircraft comprises: a laser source for emitting pulsed laser beams substantially at a predetermined wavelength; a plurality of first optical elements for directing the laser beams from a first optical path to a second optical path which exits the first optical elements; a plurality of second optical elements configured to form a telescope, the second optical path and telescope field of view being fixedly co-aligned; an optical scanner for directing the second optical path and telescope field of view to desired ground positions while maintaining the co-alignment thereof; the telescope for receiving Doppler wavelength shifted reflections of the pulsed laser beams and directing the received ground reflections substantially over a third optical path; an optical filter element for separating the ground reflections of the third optical path into first and second portions that are dependent on the Doppler wavelength shift of the g

Abstract: A method of laser scanning a perimeter zone of a target site for the detection of potential threats comprises: scanning a pulsed laser beam across the perimeter zone; receiving echoes from the pulsed laser beam during the perimeter zone scan; deriving range data corresponding to the received echoes; determining position data of the received echoes in the perimeter zone; forming a scene image of a scan of the perimeter zone based on the range and position data of the received echoes thereof; repeating the steps of scanning, receiving, deriving, determining and forming for a plurality of perimeter zone scans to form scene images of each scan of the plurality; and comparing scene images of the plurality to detect a potential threat in the perimeter zone.

Abstract: Combined laser-based apparatus for determining both altitude and ground velocity of an aircraft comprises: a laser source for emitting pulsed laser beams substantially at a predetermined wavelength; a plurality of first optical elements for directing the laser beams from a first optical path to a second optical path which exits the first optical elements; a plurality of second optical elements configured to form a telescope, the second optical path and telescope field of view being fixedly co-aligned; an optical scanner for directing the second optical path and telescope field of view to desired ground positions while maintaining the co-alignment thereof; the telescope for receiving Doppler wavelength shifted reflections of the pulsed laser beams and directing the received ground reflections substantially over a third optical path; an optical filter element for separating the ground reflections of the third optical path into first and second portions that are dependent on the Doppler wavelength shift of the g

Abstract: A method of identifying an object in a laser beam illuminated scene based on material types comprises the steps of: emitting a pulsed beam of laser energy, each beam pulse comprising a plurality of different discrete wavelength emission components; illuminating a predetermined scene with the pulsed beam; receiving return laser pulses from objects within the illuminated scene, each return laser pulse comprising return components corresponding to the plurality of different discrete wavelength emission components; determining spectral reflectance values for the plurality of return components of each return laser pulse; determining a material type for each return laser pulse of the illuminated scene based on the plurality of reflectance values of the corresponding return pulse; indexing each determined material type to a position in the illuminated scene; and identifying an object in the illuminated scene based on material types and indexed positions thereof in the scene.

Abstract: A personal radio-based hearing aid system is provided. The hearing aid system interfaces with existing hearing aids using the “T” facility. The system comprises a switchable unidirectional or omnidirectional microphone; a line input; and an FM radio transmitter. The components are housed in a discrete hand-held unit with integral stand, and a FM receiver unit connected to an inductive loop to form a discrete pendant and necklace. The prime use of said system is to give the user greater control over his environment by using the system to compensate for the loss of natural aural focus.