Patents by Inventor James K. Johnson
James K. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117388Abstract: Enzymes and recombinant host cells for the biosynthesis of clinically important prenylated polyketides of the cannabinoid family are provided. Using readily available starting materials, heterologous enzymes (e.g., bacterial CoA-transferases and CoA-ligases) are used to direct cannabinoid biosynthesis in host cells such as recombinant yeast cells.Type: ApplicationFiled: January 20, 2022Publication date: April 11, 2024Inventors: James T. KEALEY, James P. CRAIG, Jianping SUN, Charles K. MARLOWE, Colin W. JOHNSON, Philip J. BARR
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Patent number: 11954565Abstract: A technology is described for automating deployment of a machine learning model. An example method may include receiving, via a graphical user interface, credentials for connecting to a data store containing a plurality of datasets and connecting to the data store using the credentials. A selection of a target metric to predict using the machine learning model can be received, via the graphical user interface, and datasets included in the plurality of datasets that correlate to the target metric can be identified by analyzing the datasets to identify an association between the target metric and data contained within the datasets. The datasets can be input to the machine learning model to train the machine learning model to generate predictions of the target metric, and the machine learning model can be deployed to computing resources in a service provider environment to generate predictions associated with the target metric.Type: GrantFiled: May 20, 2019Date of Patent: April 9, 2024Assignee: QLIKTECH INTERNATIONAL ABInventors: Killian B. Dent, James M. Friedman, Allan D. Johnson, Shauna J. Moran, Tyler P. Cooper, Chris K. Knoch, Nicholas R. Magnuson, Daniel J. Wallace
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Patent number: 11918977Abstract: Contaminate-sequestering coatings including a network of hydrolyzed silane compounds including a plurality of thiol functional groups, a plurality of fluorinated functionalities, or both are provided. The contaminate-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species or any combination thereof. Methods of functionalizing a substrate surface with contaminate-sequestering functionalities that sequester one or more PFAS, heavy metals, or both are also provided. Methods of removing contaminants from contaminate-containing liquids, and devices including the contaminate-sequestering coatings are also provided.Type: GrantFiled: August 22, 2022Date of Patent: March 5, 2024Assignee: The Johns Hopkins UniversityInventors: Christopher M. Hoffman, Jr., Zhiyong Xia, James K. Johnson
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Patent number: 11766433Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-Type: GrantFiled: November 4, 2020Date of Patent: September 26, 2023Assignee: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang, Serene Tai, Keita Takubo, John Milligan
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Publication number: 20230027521Abstract: Contaminant-sequestering coatings include a network of hydrolyzed silane compounds including (i) a plurality of fluorinated functionalities, and (ii) a plurality of thiol functional groups are provided. The network of hydrolyzed silane compounds includes a fluorinated silane including (a) a hydrophilic polar head region. The polar head region includes one or multiple units of ethylene glycol (EG) functionality, (b) a fluorine-containing region, and (c) an anchor region including a silicon atom. The contaminant-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species, or any combination thereof.Type: ApplicationFiled: August 22, 2022Publication date: January 26, 2023Inventors: Christopher M. Hoffman, JR., Zhiyong Xia, James K. Johnson
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Publication number: 20230001251Abstract: A contaminant-sequestering coating includes a network of hydrolyzed silane compounds. The hydrolyzed silane compounds include a hydrophilic polar head region, a hydrophobic linker, and an anchor region including a silicon atom. The network of hydrolyzed silane compounds is devoid or substantially devoid of fluorine atoms. Methods of destroying one or more perfluoroalkyl and/or polyfluoroalkyl (PFAS) compounds present in a contaminant-containing liquid are also provided.Type: ApplicationFiled: June 15, 2022Publication date: January 5, 2023Inventors: Zhiyong Xia, James K. Johnson, Jesse S. Ko, Nam Q. Le, Danielle R. Schlesinger, Dajie Zhang, Plamen A. Demirev
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Publication number: 20230001378Abstract: Contaminate-sequestering coatings including a network of hydrolyzed silane compounds including a plurality of thiol functional groups, a plurality of fluorinated functionalities, or both are provided. The contaminate-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species or any combination thereof. Methods of functionalizing a substrate surface with contaminate-sequestering functionalities that sequester one or more PFAS, heavy metals, or both are also provided. Methods of removing contaminants from contaminate-containing liquids, and devices including the contaminate-sequestering coatings are also provided.Type: ApplicationFiled: August 22, 2022Publication date: January 5, 2023Inventors: Christopher M. Hoffman, Jr., Zhiyong Xia, James K. Johnson
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Patent number: 11452987Abstract: Contaminate-sequestering coatings including a network of hydrolyzed silane compounds including a plurality of thiol functional groups, a plurality of fluorinated functionalities, or both are provided. The contaminate-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species or any combination thereof. Methods of functionalizing a substrate surface with contaminate-sequestering functionalities that sequester one or more PFAS, heavy metals, or both are also provided. Methods of removing contaminants from contaminate-containing liquids, and devices including the contaminate-sequestering coatings are also provided.Type: GrantFiled: June 19, 2019Date of Patent: September 27, 2022Assignee: The Johns Hopkins UniversityInventors: Christopher M. Hoffman, Jr., Zhiyong Xia, James K. Johnson
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Patent number: 11203694Abstract: An anti-fouling coating comprising a polymeric compound, wherein a backbone of the polymeric compound is covalently bonded to a quorum sensing inhibitor, and wherein the anti-fouling coating has substantially no bactericidal activity, the quorum sensing inhibitor is substantially non-leaching from the anti-fouling coating, or both.Type: GrantFiled: August 20, 2019Date of Patent: December 21, 2021Assignee: The Johns Hopkins UniversityInventors: Christopher M. Hoffman, Jr., Adam W. Freeman, Konstantinos Gerasopoulos, James K. Johnson, Felix C. Sage, Spencer A. Langevin, Reid E. Messersmith
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Publication number: 20210186963Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-Type: ApplicationFiled: November 4, 2020Publication date: June 24, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang, Serene Tai, Keita Takubo, John Milligan
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Patent number: 10980806Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-Type: GrantFiled: September 24, 2018Date of Patent: April 20, 2021Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang, Serene Tai, Keita Takubo, John Milligan
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Publication number: 20200398249Abstract: Contaminate-sequestering coatings including a network of hydrolyzed silane compounds including a plurality of thiol functional groups, a plurality of fluorinated functionalities, or both are provided. The contaminate-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species or any combination thereof. Methods of functionalizing a substrate surface with contaminate-sequestering functionalities that sequester one or more PFAS, heavy metals, or both are also provided. Methods of removing contaminants from contaminate-containing liquids, and devices including the contaminate-sequestering coatings are also provided.Type: ApplicationFiled: June 19, 2019Publication date: December 24, 2020Inventors: Christopher M. Hoffman, JR., Zhiyong Xia, James K. Johnson
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Publication number: 20200248008Abstract: An anti-fouling coating comprising a polymeric compound, wherein a backbone of the polymeric compound is covalently bonded to a quorum sensing inhibitor, and wherein the anti-fouling coating has substantially no bactericidal activity, the quorum sensing inhibitor is substantially non-leaching from the anti-fouling coating, or both.Type: ApplicationFiled: August 20, 2019Publication date: August 6, 2020Inventors: Christopher M. Hoffman, Adam W. Freeman, Kostantinos Gerasopoulos, James K. Johnson, Felix C. Sage, Spencer A. Langevin, Reid E. Messersmith
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Publication number: 20200249172Abstract: Provided is an article for detecting organic amines, wherein the article includes a solid support impregnated with an indicator reagent comprising a metal-organic framework structure. Also provided is a method of detecting organic amines, wherein the method includes the step of exposing an article comprising a solid support impregnated with an indicator reagent to a medium including an organic amine to produce a color change, wherein the indicator reagent includes a metal-organic framework structure.Type: ApplicationFiled: August 30, 2019Publication date: August 6, 2020Inventors: James K. Johnson, Kelly A. Van Houten
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Patent number: 10544110Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.Type: GrantFiled: April 24, 2018Date of Patent: January 28, 2020Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang
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Publication number: 20190022093Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20-(Z)b-(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a selenoType: ApplicationFiled: September 24, 2018Publication date: January 24, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang, Serene Tai, Keita Takubo, John Milligan
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Publication number: 20180237403Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.Type: ApplicationFiled: April 24, 2018Publication date: August 23, 2018Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang
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Publication number: 20160257657Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(?O), —S(?O)(?O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(?O)—, —S(?O)(?O)—, or —N(H)C(?O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.Type: ApplicationFiled: March 24, 2016Publication date: September 8, 2016Inventors: Peter Wipf, James K. Johnson, Erin M. Skoda, Joel B. Nelson, Zhou Wang
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Patent number: 4986755Abstract: It is useful to a sonar instructor to have a device which simulates Doppler hifting of recorded sonar signals. Such a device can consist of a digitizer operating at a fixed rate storing data in RAM. A variable read rate is calculated based on the desired Doppler shifting. Data are read from RAM at a variable rate higher or lower than the fixed rate and converted D to A before being sent to the student sonar operator.Type: GrantFiled: March 28, 1990Date of Patent: January 22, 1991Assignee: The United States of America as represented by the Secretary of the NavyInventor: James K. Johnson
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Patent number: D461435Type: GrantFiled: May 4, 2001Date of Patent: August 13, 2002Inventor: James K. Johnson