Patents by Inventor James L. Bertsch
James L. Bertsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7488953Abstract: The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.Type: GrantFiled: May 31, 2006Date of Patent: February 10, 2009Assignee: Agilent Technologies, Inc.Inventors: Steven M. Fischer, Darrell L. Gourley, James L. Bertsch
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Publication number: 20080087815Abstract: A mass spectrometer system includes a first ion source that produces ions in a first ion stream. The mass spectrometer system includes a second ion source that produces ions in a second ion stream. A capillary receives the first and second ion streams and separately introduces ions in the first and second ion streams into a mass spectrometer channel. A mass analyzer is configured to receive and analyze ions from the channel. In one aspect, the capillary introduces ions in the first and second ion streams into the mass spectrometer channel in alternating sequence.Type: ApplicationFiled: October 13, 2006Publication date: April 17, 2008Applicant: Agilent Technologies, Inc.Inventors: Harvey Dean Loucks, James L. Bertsch
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Patent number: 7329879Abstract: A device for manipulating ions which includes a perforated folder of electrically conductive material, a first electrode fixed to the holder and a second electrode extending parallel to the first electrode and spaced from the first electrode and holder. The second electrode is connected to the holder through a rigid support of electrically insulated material.Type: GrantFiled: February 22, 2005Date of Patent: February 12, 2008Assignee: Agilent Technologies, Inc.Inventors: Jeffrey T. Kernan, Edward C. Cirimele, Mingda Wang, J. Gerson Goldberg, James L. Bertsch
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Patent number: 7309859Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.Type: GrantFiled: November 30, 2005Date of Patent: December 18, 2007Assignee: Agilent Technologies, Inc.Inventors: Steven M. Fischer, Darrell L. Gourley, Patricia H. Cormia, James L. Bertsch, Karl Hanold
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Patent number: 7078681Abstract: The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.Type: GrantFiled: August 13, 2003Date of Patent: July 18, 2006Assignee: Agilent Technologies, Inc.Inventors: Steven M. Fischer, Darrell L. Gourley, James L. Bertsch
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Patent number: 7064322Abstract: The invention provides a multipole device for a mass spectrometer system. In general, the multipole device contains a plurality of conductive rods each comprising a conductive layer, a resistive layer, and an insulative layer between the conductive and resistive layers. The invention finds use in a variety of applications, including ion transport, ion fragmentation and ion mass filtration. Accordingly, the invention may be employed in a variety of mass spectrometer systems.Type: GrantFiled: October 1, 2004Date of Patent: June 20, 2006Assignee: Agilent Technologies, Inc.Inventors: Robert K. Crawford, James L. Bertsch
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Patent number: 7002146Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.Type: GrantFiled: June 8, 2004Date of Patent: February 21, 2006Assignee: Agilent Technologies, Inc.Inventors: Steven M. Fischer, Darrell L. Gourley, Patricia H. Cormia, James L. Bertsch, Karl Hanold
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Patent number: 6849846Abstract: A method of constructing an ion mirror having an axial axis which includes arranging electrode plate elements in parallel alignment along the axial axis and attaching a rigid structure to all of the electrode plate elements with adhesive, thereby fixing the electrode plate elements in their respective axial positions and parallel alignment. In an embodiment of the method, the electrode plate elements are arranged in parallel alignment by turning the electrode plate elements from a single workpiece. In an alternative embodiment, the electron plate elements are arranged in parallel alignment by stacking the electrode plate elements using precisely dimensioned spacers, and the spacers are then removed after attachment of the rigid structure.Type: GrantFiled: August 23, 2002Date of Patent: February 1, 2005Assignee: Agilent Technologies, Inc.Inventor: James L. Bertsch
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Patent number: 6812459Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.Type: GrantFiled: August 13, 2003Date of Patent: November 2, 2004Assignee: Agilent Technologies, Inc.Inventors: Steven M. Fischer, Darrell L. Gourley, Patricia H. Cormia, James L. Bertsch
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Patent number: 6797946Abstract: A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.Type: GrantFiled: August 13, 2003Date of Patent: September 28, 2004Assignee: Agilent Technologies, Inc.Inventors: James A. Apffel, Jr., Mark H. Werlich, James L. Bertsch, Paul C. Goodley, Kent D. Henry
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Publication number: 20040079881Abstract: The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.Type: ApplicationFiled: August 13, 2003Publication date: April 29, 2004Inventors: Steven M. Fischer, Darrell L. Gourley, James L. Bertsch
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Publication number: 20040046126Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.Type: ApplicationFiled: August 13, 2003Publication date: March 11, 2004Inventors: Steven M. Fisher, Darrell L. Gourley, Patricia H. Cormia, James L. Bertsch
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Publication number: 20040046118Abstract: A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.Type: ApplicationFiled: August 13, 2003Publication date: March 11, 2004Inventors: James A. Apffel, Mark H. Werlich, James L. Bertsch, Paul C. Goodley, Kent D. Henry
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Publication number: 20040036029Abstract: A method of constructing an ion mirror having an axial axis which includes arranging electrode plate elements in parallel alignment along the axial axis and attaching a rigid structure to all of the electrode plate elements with adhesive, thereby fixing the electrode plate elements in their respective axial positions and parallel alignment. In an embodiment of the method, the electrode plate elements are arranged in parallel alignment by turning the electrode plate elements from a single workpiece. In an alternative embodiment, the electron plate elements are arranged in parallel alignment by stacking the electrode plate elements using precisely dimensioned spacers, and the spacers are then removed after attachment of the rigid structure.Type: ApplicationFiled: August 23, 2002Publication date: February 26, 2004Inventor: James L. Bertsch
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Patent number: 6653626Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.Type: GrantFiled: May 23, 2002Date of Patent: November 25, 2003Assignee: Agilent Technologies, Inc.Inventors: Steven M. Fischer, Darrell L. Gourley, Patricia H. Cormia, James L. Bertsch
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Patent number: 6646257Abstract: The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (i.e. electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources.Type: GrantFiled: September 18, 2002Date of Patent: November 11, 2003Assignee: Agilent Technologies, Inc.Inventors: Steven M. Fischer, Darrell L. Gourley, James L. Bertsch
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Patent number: 6639216Abstract: A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.Type: GrantFiled: October 7, 2002Date of Patent: October 28, 2003Assignee: Agilent Technologies, Inc.Inventors: James A. Apffel, Jr., Mark H. Werlich, James L. Bertsch, Paul C. Goodley, Kent D. Henry
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Publication number: 20030075680Abstract: A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.Type: ApplicationFiled: October 7, 2002Publication date: April 24, 2003Inventors: James A. Apffel, Mark H. Werlich, James L. Bertsch, Paul C. Goodley, Kent D. Henry
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Patent number: 6498343Abstract: A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both APT electrospray and APCI operating modes.Type: GrantFiled: July 19, 2001Date of Patent: December 24, 2002Assignee: Agilent Technologies, Inc.Inventors: James A. Apffel, Mark H. Werlich, James L. Bertsch, Paul C. Goodley
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Publication number: 20020179832Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.Type: ApplicationFiled: May 23, 2002Publication date: December 5, 2002Inventors: Steven M. Fischer, Darrell L. Gourley, Patricia H. Cormia, James L. Bertsch