Patents by Inventor James L. Douglas
James L. Douglas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6880353Abstract: A vapor compression system including a refrigerant circuit having operably coupled thereto, in serial order, a compressor, a first heat exchanger, an expansion device, and a second heat exchanger. A valve is disposed within refrigerant circuit between first heat exchanger and expansion device, and has a first position and a second position. A defrost circuit having operably coupled thereto a third heat exchanger defines an inlet in fluid communication with refrigerant circuit through valve when valve is in second position, and an outlet disposed in refrigerant circuit between inlet and expansion device. A check valve is disposed in defrost circuit between third heat exchanger and outlet. The check valve allows refrigerant to return to refrigerant circuit through outlet and prevents refrigerant from entering third heat exchanger via outlet. The refrigerant flows through third heat exchanger and second heat exchanger when valve is in second position.Type: GrantFiled: July 8, 2004Date of Patent: April 19, 2005Assignee: Tecumseh Products CompanyInventors: Zer Kai Yap, James L. Douglas
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Patent number: 4927970Abstract: The present invention relates to novel intermediates of the formula ##STR1## wherein R is lower alkyl or cyclohexyl, and X is hydroxy or a conventional leaving group, and the use thereof in a process for the preparation of certain histamine H.sub.2 -antagonists.Type: GrantFiled: April 11, 1988Date of Patent: May 22, 1990Assignee: Bristol-Myers CompanyInventors: James L. Douglas, Guy Fabre, Claude Demosthene
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Patent number: 4209080Abstract: A lubricating device for use in hermetic compressors and the like wherein a rotating oil pick-up tube is partially immersed in the oil in the compressor sump, and pumps the oil upwardly by means of centrifugal action to the compressor parts which are to be lubricated. The compressor includes a vertical shaft to which the pick-up tube is connected, wherein the shaft has an open hollow lower end including a pair of locking openings in the inner surface of the hollow portion. A molded plastic oil pick-up tube, which is bifurcated at one end so as to form a pair of resilient locking arms, is inserted into the shaft until a pair of locking nibs snap into the corresponding locking openings. In order to properly orient the pick-up tube about its axis so that the locking nibs are aligned with the corresponding openings, a pair of protruding locking ears on the tube are axially aligned with a pair of corresponding slots in the lower edge of the shaft.Type: GrantFiled: November 16, 1978Date of Patent: June 24, 1980Assignee: Tecumseh Products CompanyInventor: James L. Douglas
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Patent number: 4171438Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is acylamino and Z represents optionally substituted C.sub.1 -C.sub.6 alkyl, aryl or aralkyl. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.Type: GrantFiled: July 27, 1978Date of Patent: October 16, 1979Assignee: Bristol-Myers CompanyInventors: Donald E. Horning, Leeson R. Morris, James L. Douglas
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Patent number: 4118566Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is amino, azido or acylamido and Z represents optionally substituted C.sub.1 -C.sub.6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.Type: GrantFiled: January 27, 1977Date of Patent: October 3, 1978Assignee: Bristol-Myers CompanyInventors: Donald E. Horning, Leeson R. Morris, James L. Douglas
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Patent number: 4068066Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is amino, azido or acylamido and Z represents optionally substituted C.sub.1 -C.sub.6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.Type: GrantFiled: September 23, 1976Date of Patent: January 10, 1978Assignee: Bristol-Myers CompanyInventors: Donald E. Horning, Leeson R. Morris, James L. Douglas
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Patent number: 4065622Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is amino, azido or acylamido and Z represents optionally substituted C.sub.1 -C.sub.6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.Type: GrantFiled: September 23, 1976Date of Patent: December 27, 1977Assignee: Bristol-Myers CompanyInventors: Donald E. Horning, Leeson R. Morris, James L. Douglas
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Patent number: 4013648Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is amino and Z represents an optionally substituted heterocyclic ring containing N, O or S. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such anti-bacterial agents.Type: GrantFiled: July 23, 1975Date of Patent: March 22, 1977Assignee: Bristol-Myers CompanyInventors: Donald E. Horning, Leeson R. Morris, James L. Douglas
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Patent number: 3931188Abstract: Compounds having the formula ##SPC1##In which R is cyclopropyl or cyclobutyl have been designated 3-hydroxy-17-substituted-5,6-benzomorphinans. The compounds possess potent narcotic agonist and/or antagonist activity. In particular, the compounds 3-hydroxy-17-cyclopropylmethyl-5,6-benzomorphinan and 3-hydroxy-17-cyclobutylmethyl-5,6-benzomorphinan have been found to possess both activities. These compounds are prepared by total synthesis and are not derived from opium alkaloids.Type: GrantFiled: May 6, 1974Date of Patent: January 6, 1976Assignee: Bristol-Myers CompanyInventors: James L. Douglas, Jacques Meunier, Marcel Menard