Patents by Inventor James L. Hedrick

James L. Hedrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymers with antimicrobial functionalities
    Patent number: 11058110
    Abstract: Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: July 13, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • Stimulus-responsive micellar carrier
    Patent number: 11045552
    Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: June 29, 2021
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Nathaniel H. Park, Rudy J. Wojtecki, Yang Chuan, Ashlynn Lee, Zhen Chang Liang, Shaoqiong Liu, Yi Yan Yang
  • Polyhemiaminal and polyhexahydrotriazine materials from 1,4 conjugate addition reactions
    Patent number: 11041048
    Abstract: Polyhemiaminal (PHA) and polyhexahydrotriazine (PHT) materials are modified by 1,4 conjugate addition chemical reactions to produce a variety of molecular architectures comprising pendant groups and bridging segments. The materials are formed by a method that includes heating a mixture comprising solvent(s), paraformaldehyde, aromatic amine groups, aliphatic amine Michael donors, and Michael acceptors, such as acrylates. The reaction mixtures may be used to prepare polymer pre-impregnated materials and composites containing PHT matrix resin.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: June 22, 2021
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Mareva Fevre, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki
  • Synthesis of cyclic carbonate monomers
    Patent number: 11034664
    Abstract: Techniques regarding the synthesis of cyclic carbonate monomers are provided. For example, one or more embodiments described herein can comprise a method, which can include cyclizing a functionalized diol monomer with N,N?-carbonyldiimidazole, wherein the cyclizing produces a cyclic carbonate monomer and an imidazole carbamate. The method can also include activating the imidazole carbamate with an acid, wherein the activating promotes cyclization of the imidazole carbamate into the cyclic carbonate monomer.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: June 15, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Nathaniel H. Park, James L. Hedrick, Victoria A Piunova, Pedro Arrechea, Tim Erdmann
  • Polylysine polymers with antimicrobial and/or anticancer activity
    Patent number: 11028264
    Abstract: Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: June 8, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Nathaniel H. Park, James L. Hedrick, Victoria A. Piunova, Gavin Jones, Yi Yan Yang, Pang Kern Jeremy Tan, Chuan Yang, Cherylette Anne Alexander
  • STIMULUS-RESPONSIVE MICELLAR CARRIER
    Publication number: 20210145970
    Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
    Type: Application
    Filed: December 22, 2020
    Publication date: May 20, 2021
    Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Nathaniel PARK, Rudy J. WOJTECKI, Yang CHUAN, Ashlynn LEE, Zhen Chang LIANG, Shaoqiong LIU, Yi Yan YANG
  • Antimicrobial polymers capable of supramolecular assembly
    Patent number: 11006628
    Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: May 18, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Yi Yan Yang
  • Combination therapy to achieve enhanced antimicrobial activity
    Patent number: 11007216
    Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: May 18, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: James L. Hedrick, Yi Yan Yang, Xin Ding, Chuan Yang
  • Antimicrobial polycarbonates for multidrug resistant bacteria
    Patent number: 10995177
    Abstract: Compositions and methods regarding guanidinium functionalized polycarbonates that provide potent antimicrobial activity against multidrug resistant (MDR) bacteria, including Klebsiella pneumoniae (K. pneumoniae) are provided. According to an embodiment, an antimicrobial guanidinium-functionalized polymer is provided that comprises a hydrophobic molecular backbone with cationic guanidinium moieties respectively bound to the hydrophobic molecular backbone via butyl spacer groups. The antimicrobial guanidinium-functionalized polymer self-assembles into a micelle structure with hydrophobic residuals of the antimicrobial guanidinium-functionalized polymer buried inside the micelle structure and the cationic guanidinium moieties exposed on an external surface of the micelle structure to target pathogens.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: May 4, 2021
    Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, CORAL BAY II, LLC.
    Inventors: James L. Hedrick, Yi Yan Yang, Chuan Yang
  • UTILIZING POLYMERS AND ANTIBIOTICS TO ENHANCE ANTIMICROBIAL ACTIVITY AND INHIBIT ANTIBIOTIC RESISTANCE
    Publication number: 20210121498
    Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.
    Type: Application
    Filed: December 29, 2020
    Publication date: April 29, 2021
    Inventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
  • METHOD FOR THE FABRICATION OF THREE-DIMENSIONAL OBJECTS AND APPARATUS FOR SAME
    Publication number: 20210114288
    Abstract: Methods and apparatus comprising a dewetting phase and a polymerization liquid that are immiscible, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ an optically transparent cooling apparatus to mitigate heat generated during the fabrication process, and the use of a mobile phase to provide a shearing interface to reduce interfacial adhesive forces.
    Type: Application
    Filed: October 30, 2020
    Publication date: April 22, 2021
    Inventors: Chad A. Mirkin, David A. Walker, James L. Hedrick, III
  • Antimicrobial guanidinium and thiouronium functionalized polymers
    Patent number: 10980234
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Grant
    Filed: November 16, 2019
    Date of Patent: April 20, 2021
    Assignees: Coral Bay II, LLC, Agency For Science, Technology And Research
    Inventors: Willy Chin, James L. Hedrick, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • Systems chemistry approach to polyhexahydrotriazine polymeric structures
    Patent number: 10975201
    Abstract: In some embodiments, a product, such as a thermoset, has a polyhexahydrotriazine and a self-polymerized cross-linkable polymer. In some embodiments, a product is the reaction product of a diamine, an aldehyde, and a compound having an ?,?-unsaturated electron withdrawing moiety.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: April 13, 2021
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Mareva B. Fevre, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki
  • Silica-based organogels via hexahydrotriazine-based reactions
    Patent number: 10975217
    Abstract: Silica-based organogels, including aerogels, incorporating hexahydrotriazine and/or hemiaminal species are described. These organo-silica gel materials can have applications as insulating materials. In a particular example, an aerogel includes silica groups and a hexahydrotriazine moiety with at least one nitrogen atom that is covalently linked to a silica group. Methods of making such silica-based organogels are also described.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: April 13, 2021
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Jason T. Wertz, Rudy J. Wojtecki
  • Utilizing polymers and antibiotics to enhance antimicrobial activity and inhibit antibiotic resistance
    Patent number: 10953039
    Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: March 23, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
  • POLYLYSINE POLYMERS WITH ANTIMICROBIAL AND/OR ANTICANCER ACTIVITY
    Publication number: 20210040319
    Abstract: Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
    Type: Application
    Filed: August 5, 2019
    Publication date: February 11, 2021
    Inventors: Nathaniel H. Park, James L. Hedrick, Victoria A. Piunova, Gavin Jones, Yi Yan Yang, Pang Kern Jeremy Tan, Chuan Yang, Cherylette Anne Alexander
  • COMBINATION THERAPY TO ACHIEVE ENHANCED ANTIMICROBIAL ACTIVITY
    Publication number: 20210038635
    Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.
    Type: Application
    Filed: August 5, 2019
    Publication date: February 11, 2021
    Inventors: James L. Hedrick, Yi Yan Yang, Xin Ding, Chuan Yang
  • CHEMICAL COMPOSITIONS WITH ANTIMICROBIAL FUNCTIONALITY
    Publication number: 20210040265
    Abstract: Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.
    Type: Application
    Filed: October 16, 2020
    Publication date: February 11, 2021
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • RING-OPENING POLYMERIZATIONS USING A FLOW REACTOR
    Publication number: 20200407496
    Abstract: Techniques regarding the synthesis of polyesters and/or polycarbonates through one or more ring-opening polymerizations conducted within a flow reactor and facilitated by a urea anion catalyst and/or a thiourea catalyst are provided. For example, one or more embodiments can comprise a method, which can comprise polymerizing, via a ring-opening polymerization within a flow reactor, a cyclic monomer in the presence an organocatalyst comprising a urea anion.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 31, 2020
    Inventors: Nathaniel H. Park, James L. Hedrick, Victoria A. Piunova, Dmitry Zubarev, Gavin O. Jones, Robert M. Waymouth, Binhong Lin
  • CONTROLLING A CHEMICAL REACTOR FOR THE PRODUCTION OF POLYMER COMPOUNDS
    Publication number: 20200401110
    Abstract: Techniques regarding the synthesis of one or more polymers of a target polymer class are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a recommendation component that can generate a recommended chemical reactor control setting for inverse synthesis of a polymer based on a target polymer characteristic and reactor training data.
    Type: Application
    Filed: June 18, 2019
    Publication date: December 24, 2020
    Inventors: Dmitry Zubarev, Nathaniel H. Park, Victoria A. Piunova, Sarathkrishna Swaminathan, James L. Hedrick