Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: One embodiment of a temporary enclosure structure includes a rear frame section and a pair of side frame sections. The rear frame section includes a pair of spaced apart tubular vertical support members and a pair of extensible tubular horizontal members attached between the vertical support members to define a generally planar frame. Each of the side frame sections includes a pair of extensible vertical members and a pair of extensible horizontal members connected therebetween to also define a generally planar frame. Each vertical support member of the rear frame section includes a pair of spaced apart frame supports for supporting each of the side frame sections and against which the extensible horizontal members rests. Each frame support includes a rear pipe section concentrically disposed about a vertical support and a removable fastener for connecting the rear pipe section thereto.