Abstract: Certain aspects of the present disclosure provide techniques and apparatus for quantized machine learning. A quantized input matrix is accessed at a layer of a neural network, and a first interim value is generated in an accumulator by performing matrix multiplication, using the accumulator, of the quantized input matrix and a quantized weight matrix associated with the layer of the neural network. The first interim value is normalized based at least in part on one or more leading sign bits of the first interim value, and the normalized first interim value is dequantized. A second interim value is generated by applying a rounded right-shift operation to the dequantized normalized first interim value, and activation data is generated by applying an activation function to the second interim value.

Abstract: Topical compositions and methods for using topical compositions comprising tapinarof to treat mild to moderate atopic dermatitis or plaque psoriasis are described herein. Also described are clinical endpoints for treatment of subjects diagnosed with mild to moderate atopic dermatitis, wherein about 5% to about 35% of body surface area was affected, and Investigator Global Assessment (IGA) score was greater than or equal to 3. Also described are clinical endpoints for treatment of subjects diagnosed with chronic mild to moderate plaque psoriasis for greater than or equal to 6 months, wherein about 3% to about 20% of body surface area was affected, and Physician Global Assessment (PGA) score was greater than or equal to 2.

Abstract: Disclosed herein are embodiments of nickel-based alloys. The nickel-based alloys can be used as feedstock for PTA and laser cladding hardfacing processes, and can be manufactured into cored wires used to form hardfacing layers. The nickel-based alloys can have high corrosion resistance and large numbers of hard phases such as isolated hypereutectic hard phases.

Abstract: A method includes transmitting an instruction to a motive power supply of an elastically deformable device to drive the elastically deformable device in accordance with a drive setting; measuring a force exerted on the elastically deformable device with a sensor; outputting an observed value representative of the force; comparing the observed value with a reference value corresponding with a predetermined force to be exerted on the elastically deformable device; and adjusting the drive setting based on a determination that the observed value is outside of a predetermined range of the reference value. The method prevents slack in the elastically deformable device over time. Related apparatuses, systems, techniques and articles are also described.

Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Abstract: The present invention relates to dihydro-cyclopenta-isoquinoline derivatives of formula (I): processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular, disorders caused by the interaction of IgE with the Fc?RI receptor.

Abstract: Described herein are systems and methods for providing interactive notification panels to a user. A bot apparatus receives a notification from an application program and transforms the notification into one or more interactive notification panels configured to receive user inputs and/or to provide an output to at least one user input. Based on at least one user input, the bot apparatus transmits data to the application program, which causes the application program to perform one or more actions.

Abstract: An extension for a truck bed may include a main extension flap configured to overlap a top surface of the truck bed and extend rearwardly beyond a rear edge of the truck bed and a lower reinforcing flap configured for arrangement below the truck bed and extending rearwardly and upwardly to support the main extension flap, wherein the main extension flap and the lower reinforcing flap are configured to form a removable sandwich connection on the rear edge of the truck bed.

Abstract: A fiber optic assembly is provided including a support substrate having a substantially planar surface, a signal-fiber array supported on the planar surface of the support substrate. The signal-fiber array including a plurality of optical fibers and an adhesive disposed on the plurality of optical fibers and the support substrate. Each of the optical fibers is spaced from adjacent optical fibers of the plurality of optical fibers at a precise pitch.

Abstract: Method and apparatus are described for a system that employs a change management algorithm to drive transfusion “appropriateness” by factoring evidenced-based knowledge and input from practitioners, where said algorithm may also ensure that a blood or blood product transfusion is provided to the right patient, that the blood/blood product is transfused at the right time, and that the procedure is completed for the right reason.

Abstract: Provided are modified arginine deiminase (ADI) proteins, including ADI proteins that comprise one or more substitutions which increase expression in bacteria as insoluble and refoldable inclusion bodies. Also provided are methods of producing the modified ADI proteins, compositions comprising the ADI proteins, and related methods of treating arginine-dependent and related diseases such as cancer.

Abstract: In accordance with exemplary embodiments, methods and systems are provided for providing electrical power for a manufacturing facility for manufacturing of a vehicle, the vehicle having a rechargeable energy storage system (RESS) and a processor, including: positioning the vehicle at the manufacturing facility, the manufacturing facility having an electrical component; and providing electrical power from the RESS of the vehicle to the electrical component of the manufacturing facility, in accordance with instructions provided by the processor.

Abstract: A polymer blend including 5 to 95 weight percent of a poly(ester-carbonate-carbonate) comprising 40 to 95 mole percent of ester units comprising low heat bisphenol groups and high heat bisphenol groups, wherein the ester units comprise 20 to 80 mole percent of the low heat bisphenol groups and 20 to 80 mole percent of the high heat bisphenol groups, based on the total moles of ester units in the poly(ester-carbonate-carbonate), and 5 to 60 mole percent of carbonate units comprising the low heat bisphenol groups and the high heat bisphenol groups, wherein the carbonate units comprise 20 to 80 mole percent of the low heat bisphenol groups and 20 to 80 mole percent of the high heat bisphenol groups, based on the total moles of carbonate units in the poly(ester-carbonate-carbonate); and 5 to 95 weight percent of a poly(etherimide), wherein the weight percent of each polymer is based on the total weight of the polymers in the blend, and a molded 0.

Abstract: Method and apparatus are described for a system that employs a change management algorithm to drive transfusion “appropriateness” by factoring evidenced-based knowledge and input from practitioners, where said algorithm may also ensure that a blood or blood product transfusion is provided to the right patient, that the blood/blood product is transfused at the right time, and that the procedure is completed for the right reason.

Abstract: Techniques for obtaining and processing utility consumption data (e.g., gas, water, electricity, etc.) of a utility network to determine if a violation has occurred with respect to a restriction schedule associated with a service site. By way of example, a number of utility restriction schedules associated with a number of service sites may be generated that indicate, for example, a type of restricted activity and/or event (e.g., irrigation), seasons and/or which days activity is allowed or not allowed, duration activity is allowed, and/or mitigation to take place if a violation is detected. A device (e.g., a smart utility meter, a router, etc.) may monitor utility consumption and detect a particular usage activity (e.g., irrigation) via data disaggregation. The device may compare the activity to the restriction schedule for that particular service site and perform automatic mitigation if a violation is detected.

Abstract: A system can include one or more processors; memory; a data interface that receives data; a control interface that transmits control signals for control of pumps of a hydraulic fracturing operation; and one or more components that can include one or more of a modeling component that predicts pressure in a well fluidly coupled to at least one of the pumps, a pumping rate adjustment component that generates a pumping rate control signal for transmission via the control interface, a capacity component that estimates a real-time pumping capacity for each individual pump, and a control component that, for a target pumping rate for the pumps during the hydraulic fracturing operation, generates at least one of engine throttle and transmission gear settings for each of the individual pumps using an estimated real-time pumping capacity for each individual pump where the settings are transmissible via the control interface.

Abstract: An apparatus for and a method of analyzing a sample. A laser section may include a laser arranged to direct a laser beam in a first direction towards the sample. The laser beam ablating and ionizing at least a portion of the sample to generate ions. An ion source section may include a sample holder for holding the sample. At least one component is arranged to apply an electric field for extracting at least a portion of the ions to form an ion beam traveling in a second direction. A time-of-flight section may include a detector arranged to receive the ion beam.

Abstract: In accordance with exemplary embodiments, methods and systems are provided for providing electrical power for a manufacturing facility for manufacturing of a vehicle, the vehicle having a rechargeable energy storage system (RESS) and a processor, including: positioning the vehicle at the manufacturing facility, the manufacturing facility having an electrical component; and providing electrical power from the RESS of the vehicle to the electrical component of the manufacturing facility, in accordance with instructions provided by the processor.