Patents by Inventor James M Angelastro

James M Angelastro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOMINANT NEGATIVE CEBPB AND CEBPD PROTEINS AND METHODS OF USE FOR DECREASING VIABILITY OF NEOPLASTIC CELLS
    Publication number: 20210163551
    Abstract: Dominant negative forms of CEBPB and CEBPD, and cell-penetrating forms thereof are described. Methods for using the dominant negative forms of CEBPB and CEBPD proteins, and cell-penetrating forms thereof, for decreasing viability of neoplastic cells and treating cancer in a subject are also described.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 3, 2021
    Inventors: LLOYD A. GREENE, XIAOTIAN SUN, JAMES M. ANGELASTRO
  • METHODS FOR REGULATING THE GROWTH AND/OR SURVIVAL OF TUMOR CELLS AND STEM CELLS BY MODULATING THE EXPRESSION OR FUNCTION OF THE TRANSCRIPTION FACTORS ATF5
    Publication number: 20120238462
    Abstract: The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5.
    Type: Application
    Filed: March 7, 2012
    Publication date: September 20, 2012
    Inventors: Lloyd A. Greene, James M. Angelastro
  • Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5
    Patent number: 8158420
    Abstract: The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: April 17, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Lloyd A Greene, James M Angelastro
  • Methods for promoting apoptosis and treating tumor cells inhibiting the expression or function of the transcription factor ATF5
    Patent number: 7888326
    Abstract: The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: February 15, 2011
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Lloyd A Greene, James M Angelastro
  • Methods For Regulating The Growth And/Or Survival Of Tumor Cells And Stem Cells By Modulating The Expression Or Function Of The Transcription Factor ATF5
    Publication number: 20090018096
    Abstract: The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods.
    Type: Application
    Filed: April 3, 2008
    Publication date: January 15, 2009
    Inventors: Lloyd A. Greene, James M. Angelastro