Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.

Abstract: A hand carriable container for a portable personal audio device of the type which is normally listened to with earphones. The container includes: structure for holding the portable personal audio device; a device, separate from the personal audio device, for amplifying sound from said personal audio device; a source of power separate from the personal audio device, for the amplifying mechanism; a pair of speakers; and wiring for electrically connecting the personal audio device, the speakers, and the power supply to the amplifying mechanism. The speakers are mounted in compartments which are detachable and remotely positionable from the main portion of the container. The main portion of the container includes structure for storing pre-recorded audio material. The wires to the speaker are supported by a take-up reel supported in the main portion of the container.

Abstract: A hand carriable container for a portable personal audio device of the type which is normally listened to with earphones. The container includes: structure for holding the portable personal audio device; a device, separate from the personal audio device, for amplifying sound from said personal audio device; a source of power separate from the personal audio device, for the amplifying mechanism; a pair of speakers; and wiring for electrically connecting the personal audio device, the speakers, and the power supply to the amplifying mechanism. The speakers are mounted in compartments which are detachable and remotely positionable from the main portion of the container. The main portion of the container includes structure for storing pre-recorded audio material. The wires to the speaker are supported by a take-up reel supported in the main portion of the container.

Abstract: The reversible rachet wrench which includes: a support body having a head portion and a handle support portion having a cylindrically shaped section; a rachet wheel having teeth extending around the perimeter thereof; a pawl member; a pivot member; and a rotatable handle. The pawl member, which is pivotally supported by the head portion, includes a pair of spaced apart teeth engaging members, which are alternatively engagable with the teeth on the rachet wheel. The pivot member, pivotally supported on the support body, includes first and second ends and an intermediate pivot point. The first end includes a means for engaging the coupling means provided on the pawl member. The second end includes a means for engagement with the rotatable handle.

Abstract: A sprayable, low density ablative composition consisting essentially of:A. 100 parts by weight of a mixture of 25-65% by weight of phenolic microballoons,0-20% by weight of glass microballoons,4-10% by weight of glass fibers,25-45% by weight of an epoxy-modified polyurethane resin,2-4% by weight of a bentonite dispersing aid and1-2% by weight of an alcohol activator for the bentonite;B. 1-10 parts by weight of an aromatic amine curing agent; andC. 200-400 parts by weight of a solvent.