Patents by Inventor James M. Robl

James M. Robl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for altering cell fate
    Publication number: 20020142397
    Abstract: The invention provides methods for altering the expression profile of a cell to convert the cell from one cell type to a desired cell type. These reprogrammed cells may be used in a variety of medical applications for treating a mammal in need of a particular cell type.
    Type: Application
    Filed: December 10, 2001
    Publication date: October 3, 2002
    Inventors: Philippe Collas, James M. Robl
  • Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including Parkinson's disease
    Publication number: 20020073439
    Abstract: Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.
    Type: Application
    Filed: March 24, 2000
    Publication date: June 13, 2002
    Inventors: Steven L. Stice, Jose Cibelli, James M. Robl
  • Cloning pigs using donor nuclei from differentiated cells
    Publication number: 20020035737
    Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
    Type: Application
    Filed: May 1, 2001
    Publication date: March 21, 2002
    Applicant: University of Massachusetts
    Inventors: Steven L. Stice, James M. Robl, Jose Cibelli, Paul Golueke
  • CLONED UNGULATE EMBRYOS AND ANIMALS, USE OF CELLS, TISSUES AND ORGANS THEREOF FOR TRANSPLANTATION THERAPIES INCLUDING PARKINSON'S DISEASE
    Publication number: 20020012655
    Abstract: Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.
    Type: Application
    Filed: April 27, 1998
    Publication date: January 31, 2002
    Inventors: STEVEN L. STICE, JOSE CIBELLI, JAMES M. ROBL
  • Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
    Publication number: 20010039667
    Abstract: Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.
    Type: Application
    Filed: May 1, 2001
    Publication date: November 8, 2001
    Applicant: University of Massachusetts
    Inventors: Steven L. Stice, Jose Cibelli, James M. Robl
  • Cloning pigs using donor nuclei from non-quiescent differentiated cells
    Patent number: 6235969
    Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: May 22, 2001
    Assignee: University of Massachusetts
    Inventors: Steven L. Stice, James M. Robl, Jose Cibelli, Paul Golueke
  • Cloning using donor nuclei from a non-quiesecent somatic cells
    Patent number: 6215041
    Abstract: Methods and cell lines for cloning bovine embryos and offspring are provided. The resultant embryos or offspring are especially useful for the expression of desired heterologous DNAs.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: April 10, 2001
    Assignee: University of MMassachusetts
    Inventors: Steven L. Stice, Jose Cibelli, James M. Robl, Paul Golueke, D. Joseph Jerry
  • Prolonged culturing of avian primordial germ cells (PGCs) using specific growth factors, use thereof to produce chimeric avians
    Patent number: 6156569
    Abstract: A culture system for maintaining avian PGCs for long periods in tissue culture is provided. This culture system uses LIF, bFGF, IGF and SCF. The resultant PGCs are useful for the production of transgenic and chimeric avians, in particular, chickens or turkeys.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: December 5, 2000
    Assignee: University of Massachusetts Office of Vice Chancellor for Research at Amherst
    Inventors: F. Abel Ponce de Leon, Catherine Blackwell, Xiu Ying Gao, James M. Robl, Steven L. Stice, D. Joseph Jerry