Patents by Inventor James Manley
James Manley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210108199Abstract: Knock down or other inhibition of C9ORF72 expression provides a method of treating cancer, in particular cancers susceptible to PARP inhibition such as glioblastoma. Thus, agents that target C9orf72, such as inhibitory oligonucleotides or antibodies can be used to treat cancers. A specific embodiment includes methods for treating cancers by administrating such agents, such as an inhibitory oligonucleotide that targets C9orf72. Also disclosed are methods that involve the co-administration of a PARP inhibitor and an agent that targets C9ORF72.Type: ApplicationFiled: September 6, 2018Publication date: April 15, 2021Inventors: Vitalay Fomin, James Manley, Carol Prives
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Patent number: 9655601Abstract: A surgical tool having an elongate shaft, with a directional operative element at its distal end, is provided with a mechanism to rotate the shaft and the operative element about a longitudinal axis shaft. This allows the operative element to be aligned with an element of tissue without excessive hand movement by the user. In a preferred version, the mechanism is electrically powered and is regulated to produce smooth, controlled, accurate motion between selected rotational positions. The mechanism may include a linear magnetic motor drive to move a drive element longitudinally along the tool. This drive element is engaged with a helical formation on a drive shaft, such that longitudinal motion of the drive element is converted to rotational motion of the drive shaft, and of the shaft and operative element, to which the shaft is mounted.Type: GrantFiled: February 23, 2016Date of Patent: May 23, 2017Assignee: SRA DEVELOPMENTS LIMITEDInventors: Michael John Radley Young, Christopher John Leaver, Nicholas Charles Wright, Peter James Manley
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Publication number: 20160242753Abstract: A surgical tool having an elongate shaft, with a directional operative element at its distal end, is provided with a mechanism to rotate the shaft and the operative element about a longitudinal axis shaft. This allows the operative element to be aligned with an element of tissue without excessive hand movement by the user. In a preferred version, the mechanism is electrically powered and is regulated to produce smooth, controlled, accurate motion between selected rotational positions. The mechanism may include a linear magnetic motor drive to move a drive element longitudinally along the tool. This drive element is engaged with a helical formation on a drive shaft, such that longitudinal motion of the drive element is converted to rotational motion of the drive shaft, and of the shaft and operative element, to which the shaft is mounted.Type: ApplicationFiled: February 23, 2016Publication date: August 25, 2016Applicant: SRA DEVELOPMENTS LIMITEDInventors: Michael John Radley YOUNG, Christopher John LEAVER, Nicholas Charles WRIGHT, Peter James MANLEY
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Patent number: 9421489Abstract: Provided is a filter that filters air flowing from the filter to a downstream component, while preventing fluid from flowing from the filter to the downstream component and preventing a substance, such as urea or fuel, entering the filter from the downstream component from degrading the filter element in the filter. The filter includes a filter element having an interior surface defining an inner chamber and a standpipe extending through the inner chamber and terminating at a point that allows air that flows from outside the filter element through the filter element and into the inner chamber to flow into the standpipe and out of the filter, while preventing fluid flowing from the opposite direction through the standpipe from entering the filter element.Type: GrantFiled: June 19, 2014Date of Patent: August 23, 2016Assignee: Parker-Hannifin CorporationInventors: Randy Harbur, John K. Nichols, Jon Wake, Daniel Copley, James Manley
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Patent number: 9114140Abstract: The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory.Type: GrantFiled: December 13, 2013Date of Patent: August 25, 2015Assignee: InVivo Beverages LLCInventors: Vincent Giuliano, James Manley
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Publication number: 20140373491Abstract: Provided is a filter that filters air flowing from the filter to a downstream component, while preventing fluid from flowing from the filter to the downstream component and preventing a substance, such as urea or fuel, entering the filter from the downstream component from degrading the filter element in the filter. The filter includes a filter element having an interior surface defining an inner chamber and a standpipe extending through the inner chamber and terminating at a point that allows air that flows from outside the filter element through the filter element and into the inner chamber to flow into the standpipe and out of the filter, while preventing fluid flowing from the opposite direction through the standpipe from entering the filter element.Type: ApplicationFiled: June 19, 2014Publication date: December 25, 2014Inventors: Randy Harbur, John K. Nichols, Jon Wake, Daniel Copley, James Manley
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Publication number: 20140106014Abstract: The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory.Type: ApplicationFiled: December 13, 2013Publication date: April 17, 2014Applicant: InVivo Beverages LLCInventors: Vincent Giuliano, James Manley
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Patent number: 8609162Abstract: The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive functions for that living human subject. In particular, the initiated psychological events will generate a positive change in one's personal perceptions, evoke optimism as the subjective state of mind, and elicit a more sociable attitude and favorable mood as the observable behavior of the affected human person. Moreover, in addition to the initiation of a more positive state of mind, another major result and effect of ingesting the blended formulation is an observable amplification of human brain functions and a substantive increase of human concentration, focus and memory.Type: GrantFiled: November 30, 2012Date of Patent: December 17, 2013Assignee: InVivo Beverages LLCInventors: Vincent Giuliano, James Manley
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Publication number: 20120101495Abstract: A surgical tool having an elongate shaft, with a directional operative element at its distal end, is provided with a mechanism to rotate the shaft and the operative element about a longitudinal axis shaft. This allows the operative element to be aligned with an element of tissue without excessive hand movement by the user. In a preferred version, the mechanism is electrically powered and is regulated to produce smooth, controlled, accurate motion between selected rotational positions. The mechanism may include a linear magnetic motor drive to move a drive element longitudinally along the tool. This drive element is engaged with a helical formation on a drive shaft, such that longitudinal motion of the drive element is converted to rotational motion of the drive shaft, and of the shaft and operative element, to which the shaft is mounted.Type: ApplicationFiled: October 24, 2011Publication date: April 26, 2012Applicant: SRA DEVELOPMENTS LIMITEDInventors: Michael John Radley YOUNG, Christopher John LEAVER, Nicholas Charles WRIGHT, Peter James MANLEY
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Patent number: 7989007Abstract: The present invention comprises a purposefully formulated weight loss composition and a method for causing a meaningful weight loss in a living human subject. The formulated weight loss composition, in its most preferred embodiments comprises: at least one amino acid that is a pharmacologically active precursor in the catecholamine biosynthesis pathway; one or more sympathomimetic agents; a lipolytic agent; a high-Dalton macromolecular protein, and a plurality of micronutrients. The preferred composition is formulated as a dry particulate admixture initially; and then is made into a fluid beverage, which is able to achieve multiple physiologic functions in-vivo. These in-vivo functions include: causing a meaningful weight loss, with a preference for lipolysis and fat metabolism; providing for a low glycemic index; offering lean muscle maintenance and replenishment; and concomitantly initiating dopaminergic (D2-receptor) brain stimulation, resulting in improved cognitive function and affective augmentation.Type: GrantFiled: May 13, 2008Date of Patent: August 2, 2011Assignee: Vincent James Enterprises, LLCInventors: Vincent Giuliano, James Manley
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Publication number: 20090214680Abstract: The present invention comprises a purposefully formulated weight loss composition and a method for causing a meaningful weight loss in a living human subject. The formulated weight loss composition, in its most preferred embodiments comprises: at least one amino acid that is a pharmacologically active precursor in the catecholamine biosynthesis pathway; one or more sympathomimetic agents; a lipolytic agent; a high-Dalton macromolecular protein, and a plurality of micronutrients. The preferred composition is formulated as a dry particulate admixture initially; and then is made into a fluid beverage, which is able to achieve multiple physiologic functions in-vivo. These in-vivo functions include: causing a meaningful weight loss, with a preference for lipolysis and fat metabolism; providing for a low glycemic index; offering lean muscle maintenance and replenishment; and concomitantly initiating dopaminergic (D2-receptor) brain stimulation, resulting in improved cognitive function and affective augmentation.Type: ApplicationFiled: May 13, 2008Publication date: August 27, 2009Inventors: Vincent Giuliano, James Manley
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Publication number: 20050247596Abstract: A multi compartment container where a lid assembly has a lower part thereof setting down within the compartment defining base yet itself providing multiple compartments each closable by a lid.Type: ApplicationFiled: May 7, 2004Publication date: November 10, 2005Inventors: James Manley, Allin Russell
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Patent number: 6963197Abstract: A fault indicator for indicating the occurrence of a fault in an electrical conductor is reset at a predetermined time after the fault is detected, such as about 4 hours. The fault indicator has a housing, a high capacity battery, a fault sensor, a display for indicating a fault condition, and a programmable controller with a sleep state that draws low quiescent current. As a result the battery is expected to last the lifetime of the fault indicator. The fault indicator may optionally include current inrush restraint and/or voltage inrush restraint to inhibit the controller from activating the display to the fault indicating condition during the inrush conditions. The electromagnetic field about the conductor causes an electrostatic sensor to develop a differential voltage signal between two electrodes of different areas for the voltage inrush restraint circuit. Auxiliary contacts are provided to remotely monitor the fault indicator.Type: GrantFiled: May 30, 2003Date of Patent: November 8, 2005Assignee: E.O. Schweitzer Manufacturing Co., LLC.Inventors: Laurence Virgil Feight, James Manley Duros, Kurt James Fenske
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Patent number: 6437440Abstract: An interconnect structure and barrier layer for electrical interconnections is described incorporating a layer of TaN in the hexagonal phase between a first material such as Cu and a second material such as Al, W, and PbSn. A multilayer of TaN in the hexagonal phase and Ta in the alpha phase is also described as a barrier layer. The invention overcomes the problem of Cu diffusion into materials desired to be isolated during temperature anneal at 500° C.Type: GrantFiled: January 16, 2001Date of Patent: August 20, 2002Assignee: International Business Machines CorporationInventors: Cyril Cabral, Jr., Patrick William Dehaven, Daniel Charles Edelstein, David Peter Klaus, James Manley Pollard, III, Carol L. Stanis, Cyprian Emeka Uzoh
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Publication number: 20020046874Abstract: An interconnect structure and barrier layer for electrical interconnections is described incorporating a layer of TaN in the hexagonal phase between a first material such as Cu and a second material such as Al, W, and PbSn. A multilayer of TaN in the hexagonal phase and Ta in the alpha phase is also described as a barrier layer. The invention overcomes the problem of Cu diffusion into materials desired to be isolated during temperature anneal at 500° C.Type: ApplicationFiled: January 16, 2001Publication date: April 25, 2002Applicant: International Business Machines CorporationInventors: Cyril Cabral, Patrick William Dehaven, Daniel Charles Edelstein, David Peter Klaus, James Manley Pollard, Carol L. Stanis, Cyprian Emeka Uzoh
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Patent number: 6291885Abstract: An interconnect structure and barrier layer for electrical interconnections is described incorporating a layer of TaN in the hexagonal phase between a first material such as Cu and a second material such as Al, W, and PbSn. A multilayer of TaN in the hexagonal phase and Ta in the alpha phase is also described as a barrier layer. The invention overcomes the problem of Cu diffusion into materials desired to be isolated during temperature anneal at 500° C.Type: GrantFiled: July 18, 1997Date of Patent: September 18, 2001Assignee: International Business Machines CorporationInventors: Cyril Cabral, Jr., Patrick William DeHaven, Daniel Charles Edelstein, David Peter Klaus, James Manley Pollard, III, Carol L. Stanis, Cyprian Emeka Uzoh
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Patent number: D850188Type: GrantFiled: January 26, 2018Date of Patent: June 4, 2019Assignee: SISTEMA PLASTICS LIMITEDInventors: Cameron Lindsay, James Manley