Abstract: A method of producing an intermediate program representation for an executable personalised medicine treatment program, comprising: providing a domain specific language environment comprising a personalised-medicine programming language syntax and a user interface; selecting a medical knowledge database for a medical condition; receiving user input to build, using the personalised-medicine programming language syntax and the medical knowledge database, a treatment package for implementing one or more treatment modalities for the medical condition, the treatment package including: treatment objectives defining terminating conditions of the one or more treatment modalities; safety guardrails for ensuring patient safety; and treatment titration definitions for modulating the one or more treatment modalities; and validating the treatment package to demonstrate that the treatment objectives, safety guardrails and treatment titration definitions will be satisfied during execution of the personalised medicine treatm

Abstract: A digital treatment system, comprising: a core package; and a treatment package; wherein the core package is software partitioned from the treatment package, wherein the core package is adapted to: receive a treatment configuration from the treatment package; and configure one or more patient treatment therapies based on the treatment configuration.

Abstract: Described are systems and methods for facilitating an on-line transaction. An information item is received from an on-line location. The information item is related to an available item. A potential recipient of the available item is identified. The potential recipient is qualified for notification of the available item by determining a physical proximity between the available item and an offeror of the item. The potential recipient is qualified for notification of the available item by determining a relationship between the offeror of the item and the potential recipient. An electronic notification is generated for the qualified potential recipient in response to the physical proximity determination and the relationship determination.

Abstract: The disclosure relates to a method for identifying and preventing propagation of a DOS attack on a WS-Notification NotificationBroker by inspecting the subscription request. If the address of the NotificationConsumer identified by the subscription request is equivalent to that of the NotificationBroker then the subscription request is rejected.