Abstract: A method of vacuum arc remelting an ingot provided in a crucible assembly having an electrode includes generating a rotating magnetic field normal to a longitudinal axis of the ingot and localized to an arc region during remelting. The rotating magnetic field interacts with a melting current to produce a rotating arc directed radially outward.

Abstract: Embodiments of a method for making a contoured glass article and the resulting contoured glass article are disclosed. In one or more embodiments, the method includes cold bending a flat glass sheet having first and second opposing major surfaces, at least one region having a first thickness, and at least one region having a second thickness that is less than the first thickness, to produce cold bent glass sheet having at least one bend region along a portion of the at least one region having the second thickness; and restraining the cold bent glass sheet to produce the contoured glass article. One or more embodiments pertain to the resulting contoured glass article.

Abstract: A method of vacuum arc remelting an ingot provided in a crucible assembly having an electrode includes generating a rotating magnetic field normal to a longitudinal axis of the ingot and localized to an arc region during remelting. The rotating magnetic field interacts with a melting current to produce a rotating arc directed radially outward.

Abstract: The present disclosure relates to compositions and methods for rapid prediction, based upon early single cell transcriptomic assessment of a biopsied sample obtained from a subject, of whether a subject will be responsive to a drug.

Abstract: In some embodiments, a process comprises fixing a first portion of a flexible glass substrate into a first fixed shape with a first rigid support structure and attaching a first display to the first portion of the flexible glass substrate or to the first rigid support structure. After fixing the first portion and attaching the first display, and while maintaining the first fixed shape of the first portion of the flexible glass substrate and the attached first display, cold-forming a second portion of the flexible glass substrate to a second fixed shape and fixing the second portion of the flexible glass substrate into the second fixed shape with a second rigid support structure.

Abstract: A vacuum arc remelting system for forming an ingot from an electrode is provided that includes a crucible assembly configured to accommodate the electrode and the ingot, an electromagnetic energy source arranged about the crucible assembly, and a lift mechanism operable to move the electromagnetic energy source along a longitudinal axis of the crucible assembly. A magnetic field generated by the electromagnetic energy source is localized to an arc region during remelting, and in one form, the electromagnetic energy source is a coil assembly having a magnetic core and a plurality of coil pairs wrapped around the core, wherein the coil assembly is operable to generate a magnetic field from the coil based on electric current flowing in the plurality of coil pairs.

Abstract: In some embodiments, a process comprises fixing a first portion of a flexible glass substrate into a first fixed shape with a first rigid support structure and attaching a first display to the first portion of the flexible glass substrate or to the first rigid support structure. After fixing the first portion and attaching the first display, and while maintaining the first fixed shape of the first portion of the flexible glass substrate and the attached first display, cold-forming a second portion of the flexible glass substrate to a second fixed shape and fixing the second portion of the flexible glass substrate into the second fixed shape with a second rigid support structure.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.

Abstract: A security client can be configured to operate on the one or more computing systems and record all events occurring on the one or more computing systems. The security client can operate as a “security camera” for the computing systems by identifying and retaining data and information that describes and details different events that occur on the computing systems. The security client can be configured to generate event records for the events that are uniquely associated with the process that requested or performed event. Likewise, the security client can be configured to uniquely associate the event records with the specific computing system associated with the event.

Abstract: Embodiments of a method for making a contoured glass article and the resulting contoured glass article are disclosed. In one or more embodiments, the method includes cold bending a flat glass sheet having first and second opposing major surfaces, at least one region having a first thickness, and at least one region having a second thickness that is less than the first thickness, to produce cold bent glass sheet having at least one bend region along a portion of the at least one region having the second thickness; and restraining the cold bent glass sheet to produce the contoured glass article. One or more embodiments pertain to the resulting contoured glass article.

Abstract: In some embodiments, a process comprises fixing a first portion of a flexible glass substrate into a first fixed shape with a first rigid support structure and attaching a first display to the first portion of the flexible glass substrate or to the first rigid support structure. After fixing the first portion and attaching the first display, and while maintaining the first fixed shape of the first portion of the flexible glass substrate and the attached first display, cold-forming a second portion of the flexible glass substrate to a second fixed shape and fixing the second portion of the flexible glass substrate into the second fixed shape with a second rigid support structure.

Abstract: Disclosed herein are applique assemblies (200) comprising a substrate (210) comprising a first non-planar surface (220) defining a recess and a glass sheet (230) having a thickness of less than about 3 mm, wherein the glass sheet is configured to fit within the recess, and further wherein the glass sheet is cold formed to conform to the first non-planar surface. The applique assembly may include a chemically strengthened or non-chemically strengthened glass sheet having a thickness ranging from about 0.1 mm to about 2 mm. The applique assembly may be used to cover structural elements on the exterior of a vehicle.

Abstract: A security client can be configured to operate on the one or more computing systems and record all events occurring on the one or more computing systems. The security client can operate as a “security camera” for the computing systems by identifying and retaining data and information that describes and details different events that occur on the computing systems. The security client can be configured to generate event records for the events that are uniquely associated with the process that requested or performed event. Likewise, the security client can be configured to uniquely associate the event records with the specific computing system associated with the event.

Abstract: A vacuum arc remelting system for forming an ingot from an electrode is provided that includes a crucible assembly configured to accommodate the electrode and the ingot, an electromagnetic energy source arranged about the crucible assembly, and a lift mechanism operable to move the electromagnetic energy source along a longitudinal axis of the crucible assembly. A magnetic field generated by the electromagnetic energy source is localized to an arc region during remelting, and in one form, the electromagnetic energy source is a coil assembly having a magnetic core and a plurality of coil pairs wrapped around the core, wherein the coil assembly is operable to generate a magnetic field from the coil based on electric current flowing in the plurality of coil pairs.

Abstract: Disclosed herein are applique assemblies (200) comprising a substrate (210) comprising a first non-planar surface defining a recess and a glass sheet (230) having a thickness of less than about 3 mm, wherein the glass sheet is configured to fit within the recess, and further wherein the glass sheet is cold formed to conform to the first non-planar surface. The applique assembly may include a chemically strengthened or non-chemically strengthened glass sheet having a thickness ranging from about 0.1 mm to about 2 mm. The applique assembly may be used to cover structural elements on the exterior of a vehicle.

Abstract: Compositions and methods are provided for enriching mitochondrial DNA and optionally chloroplast DNA from eukaryotic cells in a simple rapid method that provides greater than 100 fold enrichment. Affinity protein-coated substrate in a buffer is used to efficiently bind chromosomal DNA and thereby remove it from the buffer. Mitochondrial sequencing reads reveal that non-biased sequence selection providing representation of a substantial proportion of mitochondrial DNA in the eukaryotic cells analyzed.

Abstract: Compositions and methods are provided for enriching non-target polynucleotides from a mixture of non-target and target polynucleotides where differences between the target polynucleotides and the non-target polynucleotides include the extent of modified bases that are present in a greater density in the target polynucleotides than in the non-target polynucleotides. This permits the target polynucleotides to be selectively and rapidly bound to an affinity matrix such as affinity protein-coated magnetic beads providing enrichment of the non-target polynucleotides in the supernatant. One use of this enrichment is to remove human genomic DNA from a mixture of DNAs obtained from human tissue samples to enrich for polynucleotides in a microbiome so as to characterize the microbiome by DNA sequencing.

Abstract: Automating the processes of receiving, storing and analyzing blood glucose readings obtained from a diabetic using one or more computer-based systems may provide a number of advantages in the management of levels of glucose in the diabetic's blood. Information regarding a blood glucose reading obtained from a user may be transmitted in one or more messages to the user, to an interested party (e.g. family member), or to a third party over a network, and may serve as the basis for a computer-based motivation strategy to encourage the diabetic to comply with a blood glucose management regime. Additionally, such information may be manually or automatically posted to a social network, thereby enabling the diabetic to receive words of encouragement and support from his or her social network connections, and thereby increase his or her motivation to comply with the blood glucose management regime accordingly.

Abstract: Compositions and methods are provided for enriching non-target polynucleotides from a mixture of non-target and target polynucleotides where differences between the target polynucleotides and the non-target polynucleotides include the extent of modified bases that are present in a greater density in the target polynucleotides than in the non-target polynucleotides. This permits the target polynucleotides to be selectively and rapidly bound to an affinity matrix such as affinity protein-coated magnetic beads providing enrichment of the non-target polynucleotides in the supernatant. One use of this enrichment is to remove human genomic DNA from a mixture of DNAs obtained from human tissue samples to enrich for polynucleotides in a microbiome so as to characterize the microbiome by DNA sequencing.

Abstract: A novel bottle being ergonomically designed for active consumers is disclosed herein. In a preferred embodiment, the bottle has a design ideally shaped to mate to a user's hand that is ideally suited to walkers or even runners, for example. The embodiment further comprises an outer container having a vent hole, and an inner liner further coupled to a one-way valve; and together, this combination of structure reduces sloshing as is common in a partially filled bottle. Additionally, the inner liner is disposable and biodegradeable, and therefore the bottle outer container does not have to be washed or through away, that may otherwise pollute our environment, and increase consumption of raw materials. Ideally, the sports bottle herein comprises low-density polyethylene for comfort and easy squeezing of the outer container. Also, a novel method for lining a sports bottle (or bottle for other purpose) is disclosed herein.