Abstract: A combined on-package and off-package memory system uses a custom base-layer within which are fabricated one or more dedicated interfaces to off-package memories. An on-package processor and on-package memories are also directly coupled to the custom base-layer. The custom base-layer includes memory management logic between the processor and memories (both off and on package) to steer requests. The memories are exposed as a combined memory space having greater bandwidth and capacity compared with either the off-package memories or the on-package memories alone. The memory management logic services requests while maintaining quality of service (QoS) to satisfy bandwidth requirements for each allocation. An allocation may include any combination of the on and/or off package memories. The memory management logic also manages data migration between the on and off package memories.

Abstract: A plurality of chiplets may be used to multiply two matrices A and B. Matrix A may be decomposed into horizontal stripes and matrix B may be decomposed into vertical stripes. Each of the horizontal stripes may be multiplied by each of the vertical stripes to form the output matrix C. Specifically, horizontal stripes may be stored in a stationary, distributed manner across the chiplets, while the vertical stripes (or sub-vertical stripes) may be passed between respective pairs of the chiplets until each of the vertical stripes (or sub-vertical stripes) of matrix B has been received and processed by each of the chiplets. The vertical stripes may be passed along one or more paths that interconnect the chiplets. Similar techniques can be applied to an arrangement in which the vertical stripes are stationary and the horizontal stripes (or sub-horizontal stripes) are passed between respective pairs of the chiplets.

Abstract: A management server in communication with one or more object tracking devices is disclosed. The management server may receive location information, configuration information, and orientation information associated with the one or more object tracking devices. Based at least in part on the location information, the management server may receive weather information associated with the locations of the one or more object tracking devices. Based at least in part on the location information, the weather information, the configuration information, and the orientation information, the management server can determine power generated and power consumed by the one or more object tracking devices, which then can be used to determine estimated operation time for the one or more object tracking devices.

Abstract: A jump starter for charging or boosting a depleted or discharged battery, the jump starting device, including a rechargeable battery; a positive battery connector for connecting the jump starting device to a positive terminal of the battery; a negative battery connector for connecting the jump starting device to a negative terminal of the battery; a power switch for connecting the rechargeable battery to the depleted or discharged battery when connected to the jump starting device during charging operation of the depleted or discharged battery; a first detector for detecting presence of the depleted or discharged battery connected to the positive and negative battery connectors; and a second detector for detecting presence of the depleted or discharged battery connected to the positive and negative battery connectors.

Abstract: An implantable medical device, including a magnet and a body encompassing the magnet, wherein the implantable medical device includes structural components in the body configured to move away from one another upon initial rotation of the magnet relative to the body when the magnet is subjected to an externally generated magnetic field, thereby limiting rotation of the magnet beyond the initial rotation.

Abstract: Described herein are methods and pharmaceutical formulations for treating dry eye disease.

Abstract: A loaded perforating gun and/or downhole perforating tool are assembled and used for perforating a wellbore. The loaded perforating gun includes a gun housing, a detonator assembly, and a plunging charge assembly. The plunging charge assembly includes a charge tube, a shaped charge, and a plunger. The plunger includes a receiving cap, and a detonator cord supported in the receiving cap. The shaped charge is operatively connected to the detonator cord. The detonator is selectively connected to the detonator cord by the plunger. The plunging charge assembly is movable between a disarmed position with the detonator cord disconnected from the detonator assembly and an armed position with the detonator cord operatively connected to the detonator assembly whereby, when the detonator can selectively pass a detonation signal via the detonator cord to the shaped charges.

Abstract: A raising assembly for use with a gangway connected for rotation between a raised stowed position and a lowered deployed position. The raising assembly comprises at least one fluid actuated cylinder connected to the gangway. A raising actuator is operative to cause operation of the cylinder in a manner that rotates the gangway toward the stowed position while the raising actuator is continuously activated by an operator. A lowering actuator is operative to cause operation of the cylinder in a manner that rotates the gangway toward the deployed position due to gravitational forces while the lowering actuator is continuously activated by the operator. The raising assembly is configured to maintain the gangway at a current position between the stowed position and the deployed position if the operator does one of ceasing to activate the raising actuator while raising the gangway or ceasing to activate the lowering actuator while lowering the gangway.

Abstract: Aspects of the subject disclosure may include, for example, receiving information about an augmented reality (AR) environment which includes a plurality of objects and a user participating in the AR environment, the user viewing the AR environment through a user equipment, receiving context information for the AR environment, identifying a diminished reality (DR) object of the plurality of objects, wherein the identifying is responsive to the context information, modifying the AR environment to render the DR object invisible to the user viewing the AR environment through user equipment, monitoring movement of one or more objects of the AR environment including the DR object, and modifying visibility of the DR object to the user viewing the AR environment through user equipment as a notification of a possible collision between the user and the DR object, wherein the modifying is responsive to detecting a risk of collision. Other embodiments are disclosed.

Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: A controlled extraction of an electronic connector from an electronic circuit board includes a press mechanism of a device positioned in spaced relation over a base fixture of the device. The base fixture receiving an electronic circuit board which includes a connector. Shafts of a removal tool of the press mechanism can be inserted into a series of openings in the connector, respectively, in response to applying a downward force to the press mechanism. A capturing element on each of the shafts can be actuated where the capturing element couples to a wall defining the opening of each of the openings. The connector can be removed from the electronic circuit board by applying an upward force to the press mechanism which removes the connector with the capturing element of the shafts coupled to the wall of the opening, and releasing the press mechanism from the base fixture.

Abstract: The present application provides an electrical discharge machining system for drilling a hole in a workpiece using a flushing fluid. The electrical discharge machining system may include an electrode with the electrode positioned in an electrode guide, and an integrated external flushing system. The integrated external flushing system may include a guide cap and a concentric flushing channel defined between the guide cap and the electrode guide so as to allow the flushing fluid to remain attached to the electrode guide.

Abstract: Compounds of Formula (I) and Formula (II), which are capable of binding to granzyme B. Also provided herein are pharmaceutical compositions comprising such for use in, for example, imaging Granzyme B and/or treating immunoregulatory abnormalities.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: The present disclosure is directed to an electrodepositable coating composition comprising an addition polymer comprising a polymerization product of a polymeric dispersant and a second stage ethylenically unsaturated monomer composition comprising a second stage (meth)acrylamide monomer; an ionic salt group-containing film-forming polymer different from the addition polymer; and a curing agent. Also disclosed are coatings, coated substrates, and methods of coating a substrate.

Abstract: The present invention relates to an apparatus and method for securing a box cover to a watthour meter socket box and relates to an apparatus, a system including a ring and fracturable locking system, in some embodiments, and method for securing a watthour electrical meter to a socket meter box. A locking sealing ring comprises an annular band, wherein a body portion of the annular band comprises a first band portion and a second band portion, and wherein the first band portion comprises a first ring end and the second band portion comprises a second ring end. A first tab is disposed on the first ring end and comprises a connector member. A second tab is disposed on the second ring end with the second tab comprising a receiver member, and wherein the connector member is adapted for connection with the receiver member.

Abstract: This disclosure describes compositions including fluorophore-conjugated sialic acids and fluorophore-conjugated fucose and methods of making and using those compositions. A fluorophore-conjugated sialic acid may include a cytidine monophosphate activated fluorophore-conjugated sialic acids (CMP-f-SA); a fluorophore-conjugated fucose may include a guanosine 5?-diphosphate activated fluorophore-conjugated fucose (GDP-f-Fuc). Methods of using the compositions include enzymatic incorporation of a fluorophore-conjugated sialic acid or a fluorophore-conjugated fucose or both to label and detect N- and O-glycans on glycoproteins. The compositions and methods may allow for the detection of specific glycans.

Abstract: An image of a sample collection device is captured. The image of the sample collection device is analyzed to determine whether the sample collection device includes a sufficient amount of fluid sample. The image of the sample collection device is validated based on a result of the image analysis.

Abstract: A non-crosslinked polymeric heat shrink tubing including poly(ether-block-amide) (PEBA) and methods for making such non-crosslinked polymeric heat shrink tubing is provided. The non-crosslinked PEBA heat shrink tubing disclosed herein finds application, e.g., as a processing aid and final component in the manufacture of catheters and other medical devices.

Abstract: An endoluminal punch and introducer sheath are described wherein the endoluminal punch comprises a guidewire lumen through which a user is capable of placing a guidewire. The endoluminal punch system further comprises a mechanism affixed to the hub which is capable of controlling the axial positioning of the guidewire relative to the endoluminal punch distal end. The control mechanism can be released so that the endoluminal punch can be removed from a patient while retaining the guidewire in place within the patient. The endoluminal punch introducer, including a sheath and dilator, can comprise energy emitting electrodes or transducers for cutting larger size holes in stubborn (friable, scarred, or fibrotic) tissue. In other embodiments, the endoluminal punch can comprise a guidewire or stylet, wherein the guidewire or stylet is capable of emitting energy to cut through tissue.