Abstract: The present application describes stapled peptide degron chimeras, which act as protein degradation inducing moieties, either by combining a stapled peptide that binds a disease-related protein with a small molecule degron, such as a cereblon- or VHL-binding small molecule as the degron, or a polypeptide sequence degron, such as a Cop1-binding Trib peptide as the degron; or by combining a stapled peptide degron with a peptide, such as a stapled peptide, or a small molecule that binds a disease-related protein. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of stapled peptide degron chimeras which can be utilized in the treatment of proliferative disorders or other conditions whereby elimination of a disease-causing or disease-related protein would have a therapeutic benefit. The present application also provides methods for making compounds of the application and intermediates thereof.

Abstract: A press for shaping an absorbent tampon blank into a shaped tampon pledget includes a central cavity arranged and configured to accommodate an absorbent tampon blank having a front portion and a back portion. The main longitudinal axis of the press passes in the middle of the central cavity and a plurality of penetrating dies are arranged radially around the said main longitudinal axis. Each penetrating die has a pressing face on at least a fragment of its side facing the central cavity. The said press comprises at least one cam to actuate the plurality of penetrating dies. Furthermore, the plurality of penetrating dies comprises at least one penetrating die having a pressing face with a first shaped longitudinal profile, and least one penetrating die having a pressing face with a second shaped longitudinal profile.

Abstract: A digital/virtual gift product is provided for generation and customization by a giver through a service provider and for receipt by a recipient for use with a merchant. The digital/virtual gift product includes: a representation of a monetary gift value selected by the giver and depicted on the digital/virtual gift product for use and redemption with a preselected merchant; a merchant identification depicted on the digital/virtual gift product to identify the preselected merchant, selected by the giver, and at which preselected merchant the digital/virtual gift product is redeemable; and a giver identification to identify the giver of the digital/virtual gift product to the recipient and to the merchant. At least one system and associated methods also are disclosed for creating, customizing, and tracking multiple digital/virtual gift products.

Abstract: Exemplary embodiments pertain to a computer architecture for supporting transactions through a transaction card, as well as methods, mediums, and interfaces for use with the architecture. According to one embodiment, a request to perform a transaction for an identified amount between a user and a merchant server may be received at a provider server associated with a transaction card issued to the user. The provider server may identify a card value store and a primary value store associated with the user. The provider server may determine whether the transaction card is in an active state based on an occurrence of an automatic transfer between an employer institution and the primary value store in a most-recent predetermined time interval. If the card is active, the provider server may transmit a control signal to the merchant server, the control signal configured to authorize the transaction on behalf of the user.

Abstract: A doming tool for manufacturing absorbent tampon includes a plurality of stations made of devices for shaping a tampon pledget tip, and a hollow mandrel engaging with the stations. The stations are supported by at least one mounting plate.

Abstract: System and method relates to a firewater monitor brake system, comprising a vertical locking disc collar adapted to be affixed externally or internally to a horizontal swivel of a firewater monitor system; a horizontal locking disc collar adapted to be affixed externally or internally to a vertical swivel of the firewater monitor system; a vertical brake mount adapted to be affixed to a horizontal swivel mounting pad of the firewater monitor system; a horizontal brake mount adapted to be affixed to a vertical swivel mounting pad of the firewater monitor system; a vertical brake system; wherein the vertical brake system is affixed to the vertical brake mount such that a portion of the vertical brake system is disposed around a portion of the vertical locking disc collar; a horizontal brake system, wherein the horizontal brake system is affixed to the horizontal brake mount such that a portion of the horizontal brake system is disposed around a portion of the horizontal locking disc collar; and a master cylinde

Abstract: System and method relates to a firewater monitor brake system, comprising a vertical locking disc collar adapted to be affixed externally or internally to a horizontal swivel of a firewater monitor system; a horizontal locking disc collar adapted to be affixed externally or internally to a vertical swivel of the firewater monitor system; a vertical brake mount adapted to be affixed to a horizontal swivel mounting pad of the firewater monitor system; a horizontal brake mount adapted to be affixed to a vertical swivel mounting pad of the firewater monitor system; a vertical brake system; wherein the vertical brake system is affixed to the vertical brake mount such that a portion of the vertical brake system is disposed around a portion of the vertical locking disc collar; a horizontal brake system, wherein the horizontal brake system is affixed to the horizontal brake mount such that a portion of the horizontal brake system is disposed around a portion of the horizontal locking disc collar; and a master cylinde

Abstract: A method includes receiving a plurality of product query arrays each including a plurality of individual product queries received during a single user search session. The method further includes inputting the plurality of product query arrays into the query rewrite model. Text of each of the plurality of individual product queries in each product query array is treated as a whole token. The method further includes receiving a product query from a user electronic device. The method further includes determining a query rewrite for the product query using the query rewrite model and determining search results for the product query using the query rewrite. The method further includes sending information for presenting the search results on a display of the user electronic device responsive to the product query.

Abstract: A system and method for machine learning classification of user sentiment is disclosed. The method includes storing including a plurality of category information. The plurality of category information includes a set of domain-specific category information. The method further includes extracting a plurality of aspects from textual data. The method further includes generating a sentiment by a machine learning model. The method further includes receiving the plurality of aspects and the set of domain-specific category information.

Abstract: Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g.

Abstract: A laundry appliance includes a cabinet, a drum, a housing, a foreign particulate removal assembly, and a blower. The foreign particulate removal assembly includes a first lint filter that defines a plurality of first lint filter openings, a second lint filter that defines a plurality of second lint filter openings that are smaller than the plurality of first lint filter openings, such that the second lint filter is configured to collect foreign particulates that pass through at least one of the plurality of first lint filter openings, and a binding member that couples the first lint filter to the second lint filter. The foreign particulate removal assembly is operable between a collection position and a maintenance position. In the collection position, at least the second lint filter is positioned within the housing. In the maintenance position, the second lint filter is positioned outside of the housing.

Abstract: A laundry appliance includes a cabinet that has a user interface. A drum is disposed within the cabinet and includes baffles. A blower directs process air through an airflow path that includes the drum. A lint filter is disposed within the airflow path and between the drum and the blower. A foreign particulate collector is disposed within the drum and is configured to collect foreign particulates within the drum. A controller is operably coupled to a motor for rotating the drum and the blower. The user interface and the controller cooperate to operate the drum and the blower for capturing foreign particulates at least within the foreign particulate collector.

Abstract: System and method relates to a firewater monitor brake system, comprising a vertical locking disc collar adapted to be affixed externally or internally to a horizontal swivel of a firewater monitor system; a horizontal locking disc collar adapted to be affixed externally or internally to a vertical swivel of the firewater monitor system; a vertical brake mount adapted to be affixed to a horizontal swivel mounting pad of the firewater monitor system; a horizontal brake mount adapted to be affixed to a vertical swivel mounting pad of the firewater monitor system; a vertical brake system; wherein the vertical brake system is affixed to the vertical brake mount such that a portion of the vertical brake system is disposed around a portion of the vertical locking disc collar; a horizontal brake system, wherein the horizontal brake system is affixed to the horizontal brake mount such that a portion of the horizontal brake system is disposed around a portion of the horizontal locking disc collar; and a master cylinde

Abstract: Continuity-based data protection may be implemented by systems and methods described herein for collecting a set of data that corresponds to a graphical representation of a computing environment, determining a plurality of subsets of the set of data, wherein a subset of the plurality has mathematical continuity, compressing at least the subset of the plurality, thereby generating one or more compressed subsets, and providing the one or more compressed subset to another computing entity, the other computing entity being able to determine the graphical representation of the computing environment, wherein the graphical representation is presentable to a user of the other computing entity.

Abstract: System and method relates to a firewater monitor brake system, comprising a vertical locking disc collar adapted to be affixed externally or internally to a horizontal swivel of a firewater monitor system; a horizontal locking disc collar adapted to be affixed externally or internally to a vertical swivel of the firewater monitor system; a vertical brake mount adapted to be affixed to a horizontal swivel mounting pad of the firewater monitor system; a horizontal brake mount adapted to be affixed to a vertical swivel mounting pad of the firewater monitor system; a vertical brake system; wherein the vertical brake system is affixed to the vertical brake mount such that a portion of the vertical brake system is disposed around a portion of the vertical locking disc collar; a horizontal brake system, wherein the horizontal brake system is affixed to the horizontal brake mount such that a portion of the horizontal brake system is disposed around a portion of the horizontal locking disc collar; and a master cylinde

Abstract: A method includes retrieving, by a processor in an image classification system, a plurality of product images from a memory. A first image classifier is applied to a first of the plurality of product images. The first of the plurality of product images is associated with a first category. A second image classifier is applied to a second of the plurality of product images. The second of the plurality of product images is associated with a second category. A first result of the first image classifier for the first of the plurality of product images is stored in the memory. A second result of the second image classifier for the second of the plurality of product images is stored in the memory.

Abstract: Methods for providing laminated coatings on metal articles using electroplating methods such as barrel plating, vibratory plating, rocker plating or other non-rack methods that involve movement of articles to be plated in a containment apparatus, as well as articles made from such processes. Embodiments of such processes involve mass-transfer modulation to provide compositionally modulated coatings.

Abstract: Application data may be transmitted while oscillating a transmission parameter. A metric associated with a complementary network property is analyzed to identify a transition point between a stochastic error state and a deterministic error state of the complementary network property. Additional network properties or states may be inferred from the transition point, and the transmission of the application data may be optimized based on the inferred additional properties or states.

Abstract: Data is transmitted in accordance with a parameter. For a metric associated with transmission of the data, a response to a stochastic error state of the metric includes making a first adjustment to the parameter in a first direction. A response to a deterministic error state of the metric includes making a second adjustment to the parameter in a second direction, where the second direction is in opposition to the first direction. A transition point between the two states is identified, and a response to the identification is made.

Abstract: Techniques for oscillatory complementary network property calibration of a network connection can be implemented by measuring a first network property (e.g., latency or bandwidth output) as a function of bandwidth input and performing statistical analysis to determine a correlation. If a non-zero correlation coefficient is detected, a second network property complementary to the first network property can be measured to determine a first value of the second network property. Likewise, the second network property can be measured as a function of bandwidth input to determine a second correlation which, if positive, may indicate how to determine a second value of the first network property. The first value and the second value can be utilized to determine a third value of a third network property (e.g., network latency and network capacity utilized to determine bandwidth-delay product).