Abstract: Disclosed herein are recombinant meganucleases engineered to bind and cleave a recognition sequence in the mitochondrial DNA (mtDNA) of a eukaryotic cell, such as a plant cell. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.

Abstract: Embodiments described herein relate to systems, devices, and methods for use in the implementation of a brain-computer interface that integrates real-time eye-movement tracking with brain activity tracking to present and update a user interface that is strategically designed for high speed and accuracy of human-machine interaction. Embodiments described herein also relate to the implementation of a hardware agnostic brain-computer interface that uses real-time eye tracking and online analysis of neural signals to mediate user manipulation of machines.

Abstract: A motor drive or bus supply power conversion system includes a rectifier with at least one rectifier switch module for rectifying AC input power. A DC bus is connected to the rectifier and supplies DC output power. An optional inverter is connected to the DC bus and includes at least one inverter switch module for inverting the DC bus voltage to an AC output power. The at least one rectifier switch module and the at least one inverter switch module each include a base plate and a housing connected to the base plate. The housing defines an interior space that contains at least one semiconductor switch. Anti-corrosion features are provided including a conformal coating on printed circuit board assemblies, removable connector covers, dielectric grease coated connections, nano-coated fiber optic transceivers, and an exterior protective film wrap.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: A method is provided that can include activating at least two wireless communication channels in parallel, between a first wireless transceiver and a second wireless transceiver. Each of the at least two wireless communication channels can operate at a different radio carrier frequency, and the first wireless transceiver may be part of a first vehicle. The method can also include transmitting, by the first wireless transceiver, common information in parallel on the at least two wireless communication channels to the second wireless transceiver and deactivating the at least two wireless communication channels.

Abstract: A system for robotic surgery makes use of an end-effector which has been configured so that a drill connected thereto is guided in its trajectory and limited in its advancement into an associated anatomical feature by a drill guide. The drill guide may be adjusted manually to engage a corresponding surface of the drill after its advancement by a pre-selected amount. The drill guide likewise includes features to guide the drill during trajectories having oblique angles relative to the surface of the anatomical feature associated with the medical procedure.

Abstract: Embodiments use a multi-modal approach to generate software programs that match a solution program description. The solution program description may include natural language, input-output examples, partial source code, desired operators, or other hints. Some embodiments use optimized prompts to a pre-trained language model to obtain initial candidate programs. Maximal program components are extracted and then recombined variously using component-based synthesis. Beam search reduces a solution program search space by discarding some candidates from a given synthesis iteration. Relevance metrics, string similarity metrics, operator frequency distributions, token rareness scores, and other optimizations may be employed. By virtue of optimizations and the multi-modal approach, a solution program may be obtained after fewer iterations than by use of a language model alone.

Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.

Abstract: A handheld controller configured to be held by a user's hand. The handheld controller comprising a main body, and a handle extending from the main body, wherein the handle has a palm side and a finger side. A control button is positioned on the main body or handle, and a detection sensor is on the handle. The detection sensor is positioned to detect the presence of the finger or palm of a user's hand engaging the handle. The detection sensor can be a capacitive touch sensor, a proximity sensor or other detection sensor operative to detect the touch or spatial presence of the user's hand or fingers.

Abstract: Embodiments of polymer blends may include a first polymer composition and a second polymer composition. The first polymer composition may include a polyolefin having a thermal transition temperature of at least 100° C. and a graftable monomer having at least one acid or anhydride functional group grafted onto the polyolefin. The second polymer composition may include an E/X/Y ethylene interpolymer, wherein E is an ethylene monomer and comprises greater than 50 wt. % of the interpolymer, X is an ?,?-unsaturated C3-C8 carboxylic acid and comprises greater than 0 to 25 wt. % of the interpolymer, and Y is an optional comonomer comprising C1-C8 alkyl acrylate.

Abstract: The present invention relates to microbial cells, including but not limited to aerobic bacteria cells and anaerobic bacteria cells, as well as yeast cells, and methods for producing the cells, feed additives and compositions comprising the cells, and uses involving administration of the cells to animals.

Abstract: The nail gun indicator gives the user an alarm when the nail supply is or near depletion. The indicator beeps and a light comes on to make the user aware of the need to replenish the nail supply thus creating a more effective product with their nail gun of choice. This invention provides an improvement as well as an important safety feature to an existing product, a standard nail gun. The ‘Nail Gun Reload Indicator” can be attached externally or can be incorporated into the design by the manufacturer. The Nail Gun Reload Indicator is a feature that will alert the user as to the status of the nail supply in the gun. This will prevent the user from getting into a precarious situation with an inadequate supply of nails. An example would be, A carpenter on a ladder holding a heavy beam and trying to nail it in place and the nail gun is empty. Let it be noted that for the purpose of this application, the term “nail gun” will apply to all pneumatic or gas driven fasteners.

Abstract: Example posture analysis systems and methods are described. In one implementation, a computing system identifies a deviation of a user's posture from a predetermined posture based on visual data associated with the user. The user is informed of the deviation via a graphical image displayed on a display device. The user is then provided with instructions for correcting the deviation via the graphical image displayed on the display device.

Abstract: The present invention relates to microbial cells, including but not limited to aerobic bacteria cells and anaerobic bacteria cells, as well as yeast cells, and methods for producing the cells, feed additives and compositions comprising the cells, and uses involving administration of the cells to animals.

Abstract: Described herein is a computer implemented method for generating webpage data. The method includes processing a set of design element objects to generate a set of element-grid records, each record corresponding to a design element and including a unique column start, a unique column end, a column start offset and a column end offset. The set of element-grid records is processed to generate a webpage grid definition that defines a grid including a plurality of columns and a plurality of rows. A first design element and a second design element have a same horizontal start position and the webpage grid definition defines: a unique column start gridline for the first design element; a unique column start gridline for the second design element; and a zero-width first column between the first and second column gridlines.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: Described herein is a computer implemented method for generating webpage data. The method includes processing a set of design element objects to generate a set of element-grid records, each record corresponding to a design element and including a unique column start, a unique column end, a column start offset and a column end offset. The set of element-grid records is processed to generate a webpage grid definition that defines a grid including a plurality of columns and a plurality of rows. A first design element and a second design element have a same horizontal start position and the webpage grid definition defines: a unique column start gridline for the first design element; a unique column start gridline for the second design element; and a zero-width first column between the first and second column gridlines.

Abstract: Embodiments use a multi-modal approach to generate software programs that match a solution program description. The solution program description may include natural language, input-output examples, partial source code, desired operators, or other hints. Some embodiments use optimized prompts to a pre-trained language model to obtain initial candidate programs. Maximal program components are extracted and then recombined variously using component-based synthesis. Beam search reduces a solution program search space by discarding some candidates from a given synthesis iteration. Relevance metrics, string similarity metrics, operator frequency distributions, token rareness scores, and other optimizations may be employed. By virtue of optimizations and the multi-modal approach, a solution program may be obtained after fewer iterations than by use of a language model alone.

Abstract: Described herein is a computer implemented method for generating webpage data. The method includes processing a set of design element objects to generate a set of element-grid records, each record corresponding to a design element and including a unique column start, a unique column end, a column start offset and a column end offset. The set of element-grid records is processed to generate a webpage grid definition that defines a grid including a plurality of columns and a plurality of rows. A first design element and a second design element have a same horizontal start position and the webpage grid definition defines: a unique column start gridline for the first design element; a unique column start gridline for the second design element; and a zero-width first column between the first and second column gridlines.