Abstract: Acting as a proxy on behalf of a co-worker requires software and hardware entitlements to support the co-workers' duties. Such entitlements should be granted timely and maintained as long as the proxy obligations are in force. Because the proxy only accesses the co-worker's entitlements on a need-basis, there is risk that the credentials of the proxy may time-out. Because the proxy only infrequently accesses the co-worker's entitlements, the proxy may not be aware that their credentials to those entitlements have expired. Apparatus and methods for are provide for an artificial intelligence tool for managing and maintaining entitlements and for proxy, primary and secondary access credentials in complex enterprise computing environments. The tool may provide a one-stop web service and associated application for viewing current status of entitlement credentials and autonomously preventing expiration of those credentials based on current and future needs of an individual or organization.

Abstract: Novel tools and techniques are provided for implementing intent-based orchestration using network parsimony trees. In various embodiments, in response to receiving a request for network services that comprises desired characteristics and performance parameters for the requested network services without information regarding specific hardware, hardware type, location, or network, a computing system might generate a request-based parsimony tree based on the desired characteristics and performance parameters. The computing system might access, from a datastore, a plurality of network-based parsimony trees that are each generated based on measured network metrics, might compare the request-based parsimony tree with each of one or more network-based parsimony trees to determine a fitness score for each network-based parsimony tree, and might identify a best-fit network-based parsimony tree based on the fitness scores.

Abstract: Apparatus including an optical signal generator, a data transmission path, and an optical signal receiver. Optical signal generator includes a coherent light source for generating a spectrum of carrier signals at different carrier frequencies, an optical demultiplexer that receives and separates the different carrier signals into separate optical paths, a pair of optical modulators located in each of the separate optical paths to modulate each different carrier signal with a data signal and produce an upper and lower sideband pair at each of the different carrier frequencies, and an optical interleaver to combine the upper and lower sideband pairs into an optical super-channel of interleaved sub-bands. Optical signal receiver includes a demodulator for extracting the data signals. Optical modulators are configured to reuse each carrier signal to transmit different data in each of the upper sideband and the lower sideband and increase the capacity of the super-channel. Also a method.

Abstract: The present invention relates to a tight space wrench device comprised of a wrench member attached to at least one chain with at least one loop that functions as a handle. The wrench member may have any wrench head known in the art that can be positioned on a fastener. The chain can then be positioned in any area away from the fastener wherein a user can comfortably grip the loop without the risk of injury to their hand. Then, a user can pull the chain to rotate the wrench head clockwise or counterclockwise.

Abstract: Provided herein are methods, therapeutic agents and composition for treating a CNS-related disorder.

Abstract: The present invention provides a novel isolated succinate prodrug as the free compound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: Provided herein are methods, therapeutic agents and composition for treating a CNS-related disorder.

Abstract: The present invention relates to sanglifehrin macrocyclic analogues according to Formula (I), particularly for use in treatment of cancer, especially liver cancer.

Abstract: A downhole relative positioning system utilizes electromagnetic and survey measurements from a first well to calibrate a formation model, which is then used to improve the interpretation of measurements from a second well. Since the methods described herein utilize a differential approach, even though the exact position of each wellbore may not be accurately identified, their relative positions can be accurately identified.

Abstract: Provided herein are screening methods and systems for the identification and evaluation of candidate GABAergic modulators. These candidate agents or compounds are useful for treating or preventing CNS-related disorders.

Abstract: The present invention relates to uses of sanglifehrin macrocyclic analogues in treatment of cancer, especially liver cancer.

Abstract: The present invention provides novel liver-targeted prodrugs of mitochondrial proton ionophores. These compounds have utility in medicine including their use in treatment of diseases such as NASH and NAFLD.

Abstract: The invention comprises building panel assemblies for use in the construction of new homes, commercial buildings and extensions of one or more storeys. There is provided a rectangular structural insulated panel (SIP) (10), which comprises a pair of spaced-apart containment boards (12?, 12?) an inner insulating core (13) and a low profile peripheral external rigid frame (14), preferably of metal, e.g. steel, extending around the entire periphery of the spaced-apart boards (12?, 12?), the insulating core (13) having spaced-apart slots (16), which also extend around the entire periphery of the panel.

Abstract: A magnetic ranging system utilizes the natural shape of magnetic fields for steering and/or landing of one wellbore in relation to another wellbore.

Abstract: A downhole relative positioning system utilizes electromagnetic and survey measurements from a first well to calibrate a formation model, which is then used to improve the interpretation of measurements from a second well. Since the methods described herein utilize a differential approach, even though the exact position of each wellbore may not be accurately identified, their relative positions can be accurately identified.

Abstract: The invention comprises building panel assemblies for use in the construction of new homes, commercial buildings and extensions of one or more storeys. There is provided a rectangular structural insulated panel (SIP) (10), which comprises a pair of spaced-apart containment boards (12?, 12?) an inner insulating core (13) and a low profile peripheral external rigid frame (14), preferably of metal, e.g. steel, extending around the entire periphery of the spaced-apart boards (12?, 12?), the insulating core (13) having spaced-apart slots (16), which also extend around the entire periphery of the panel.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.

Abstract: An artificial toolface reference system includes a power supply providing current to a ground lead and a reference lead. A ground point is coupled to the ground lead and in electrical connection with the ground. A reference wellbore includes a reference conductor in electrical connection with the ground. The reference conductor is in electrical connection with the reference lead. A guidance sensor positioned outside the reference wellbore includes at least one magnetometer. The power supply may be used to provide a current through the reference conductor, the ground, and the ground point such that a reference magnetic field is generated along the reference conductor. The guidance sensor may measure the reference magnetic field with a magnetometer. An artificial magnetic toolface may be calculated therefrom.