Abstract: The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject.

Abstract: An unmanned aerial vehicle (UAV) system includes a command center having a computing device an unmanned aerial vehicle (UAV) with a body, the UAV to communicate wirelessly with the command center via a network, the UAV having a control system with a power source, a geospatial tracking device, and a multi-channel communication portal; a camera secured to the body and in communication with the control system; and one or more equipment attachment sites; site assessment tools to attach to or within the one or more equipment attachment sites, each of the site assessment tools to record a data associated with an emergency site, such as weather conditions, road conditions, traffic, visibility, radiation, and chemical exposure; the UAV is to receive commands from the command center to deploy to the emergency site; and the UAV is to receive the data and transmit the data to the command center via the multi-channel communication portal.

Abstract: A device for detecting and catching a leak from a fire sprinkler includes a leak sensor configured to detect the leak, and a leak catcher configured to catch the leak before the leak makes contact with surrounding areas. The device also includes an alarm module configured to issue a notification upon detection of the leak, and a mounting mechanism configured to removably mount the leak sensor, the leak catcher, and the alarm module to the fire sprinkler in a manner that does not obstruct operation of the fire sprinkler.

Abstract: A system to protect and reconfigure a computer network in case of advance warning of a disruption event that would disrupt the operation of the computer network is presented. The system comprises a main control system (MCS) that comprises a software system that makes continuous local backups of data nodes, maintains a plurality of remote backups, and maintains an ordered list of the remote backups. With the first warning of the disruption event, the MCS: 1) locks down some virtual servers at each remote backup and secures a selected remote backup; 2) determines the expected start and end time of the disruption event; 3) warns users about the disruption event; 4) uses the selected remote backup to provide a local copy of the data nodes; and 5) shuts down vulnerable critical systems. When the disruption event occurs, the MCS promotes the selected remote backup to be the primary data node.

Abstract: A system to protect and reconfigure a computer network in case of advance warning of a disruption event that would disrupt the operation of the computer network is presented. The system comprises a main control system (MCS) that comprises a software system that makes continuous local backups of data nodes, maintains a plurality of remote backups, and maintains an ordered list of the remote backups. With the first warning of the disruption event, the MCS: 1) locks down some virtual servers at each remote backup and secures a selected remote backup; 2) determines the expected start and end time of the disruption event; 3) warns users about the disruption event; 4) uses the selected remote backup to provide a local copy of the data nodes; and 5) shuts down vulnerable critical systems. When the disruption event occurs, the MCS promotes the selected remote backup to be the primary data node.

Abstract: A latch assembly and a method of disengaging the latch assembly for a vehicle door are provided. In particular, the latch assembly includes a releasing lever that is moveably attached to the latch assembly via a pawl and is moveable between an engaged and disengaged position to unlatch the latch assembly. Additionally, a lock lever interacts with an override assembly to control whether the vehicle door is opened. The override assembly requires two movements to move the lock lever to an unlocked position and to open the latch during a power failure.

Abstract: A method of performing a seismic survey including: deploying nodal seismic sensors at positions in a survey region; activating a plurality of seismic sources; and using the nodal seismic sensors to record seismic signals generated in response to the activation of the plurality of signals.

Abstract: A method of performing a seismic survey including: deploying nodal seismic sensors at positions in a survey region; activating a plurality of seismic sources; and using the nodal seismic sensors to record seismic signals generated in response to the activation of the plurality of signals.

Abstract: Utilizing a pressure-sensitive adhesive (PSA) for assembling an electronic device can have certain benefits, such as ease of automation and instant handling or short handling time that may save time, effort, and costs during manufacturing. A liquid adhesive, on the other hand, can provide superior bond strength relative to a PSA such that a device manufactured using a liquid adhesive may perform better with respect to structural rigidity, dynamic response, impact resistance, and other reliability testing. An electronic device manufacturer can take advantage of the benefits of each type of adhesive during device assembly by incorporating both a PSA and a liquid adhesive to bond two substrates of the device, such as a cover glass or sheet and a housing structure or frame.

Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: An electronic device includes an elongated tubular housing. One or more electronic components are coupled to a chassis disposed in a cavity of the tubular housing. A pair of elongated channels are positioned on opposite sides of the chassis and between the chassis and a sidewall of the tubular housing. The channels are tapered or wedge-shaped along their lengths. During assembly, one of the channels may be slid longitudinally along the other, causing the channels to expand laterally, due to their wedge shape, to secure the chassis in the tubular housing. The chassis and the pair of channels provide a thermally conductive path to dissipate heat. During use, heat generated by the electronic components is transmitted radially outward from the electronic components, through the chassis and the pair of channels, and through the tubular housing to the exterior of the portable electronic device.

Abstract: The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject.

Abstract: Disclosed are compounds, compositions, and methods relating to fluoride aptamers, fluoride-responsive riboswitches, fluoride-regulated expression constructs, fluoride transporters, nucleic acids encoding fluoride transporters, expression constructs encoding fluoride transporters, and cells containing or including any combination of these.

Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: This invention relates to a new pallet lift system for the movement of pallets via the use of a new pallet jack and dolly in conjunction with new tines to transport the pallet from one location to another and minimize the risk of damaging or marring the surface across which the pallet is moved by utilizing a pallet jack and a dolly equipped with soft wheels to allow a pallet to move over door thresholds and floor surfaces without risking damage to the surface, and to facilitate the transportation of pallets of merchandise across an uneven surface such as a parking lot, and into and through a narrow entrance such as a standard doorway and provides a method to load pallets in and out of trucks with the narrow edge leading, thus increasing the usable space inside a typical truck, the present invention being able to be used with multiple different sized pallets.

Abstract: A method of performing a seismic survey including: deploying nodal seismic sensors at positions in a survey region; activating a plurality of seismic sources; and using the nodal seismic sensors to record seismic signals generated in response to the activation of the plurality of signals.

Abstract: A three-dimensional (3D) microscope for patterned substrate measurement can include an objective lens, a reflected illuminator, a transmitted illuminator, a focusing adjustment device, an optical sensor, and a processor. The focusing adjustment device can automatically adjust the objective lens focus at a plurality of Z steps. The optical sensor can be capable of acquiring images at each of these Z steps. The processor can control the reflected illuminator, the transmitted illuminator, the focusing adjustment device, and the optical sensor. The processor can be configured to capture first and second images at multiple Z steps, the first image with the pattern using the reflected illuminator and the second image without the pattern using one of the reflected illuminator and the transmitted illuminator.

Abstract: A three-dimensional (3D) microscope for patterned substrate measurement can include an objective lens, a reflected illuminator, a transmitted illuminator, a focusing adjustment device, an optical sensor, and a processor. The focusing adjustment device can automatically adjust the objective lens focus at a plurality of Z steps. The optical sensor can be capable of acquiring images at each of these Z steps. The processor can control the reflected illuminator, the transmitted illuminator, the focusing adjustment device, and the optical sensor. The processor can be configured to capture first and second images at multiple Z steps, the first image with the pattern using the reflected illuminator and the second image without the pattern using one of the reflected illuminator and the transmitted illuminator.

Abstract: A three-dimensional (3D) microscope for patterned substrate measurement can include an objective lens, a reflected illuminator, a transmitted illuminator, a focusing adjustment device, an optical sensor, and a processor. The focusing adjustment device can automatically adjust the objective lens focus at a plurality of Z steps. The optical sensor can be capable of acquiring images at each of these Z steps. The processor can control the reflected illuminator, the transmitted illuminator, the focusing adjustment device, and the optical sensor. The processor can be configured to capture first and second images at multiple Z steps, the first image with the pattern using the reflected illuminator and the second image without the pattern using one of the reflected illuminator and the transmitted illuminator.