Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: A connector is provided to attach a supported member to a supporting member, with the supported member being in sloped and skewed relation to the supporting member. The connector has back members attached to side members. A seat member attaches to the side members through a hinged connection. The seat member interfaces with the bottom face of the supported member and can be disposed at a sloped angle. A pair of seat side members extend from the seat member.

Abstract: A personal surveillance system configured to be worn by an individual includes a communication system configured to record communication files, a locating system configured to determine a location of the personal surveillance system, and a transmitter configured to send the communication files and the location of the personal surveillance system to a remote monitoring station. The locating system includes a satellite system interface configured to determine the location of the personal surveillance system and an alternate positioning system configured to determine the location of the personal surveillance system in at least one situation where the satellite system interface cannot determine the location of the personal surveillance system.

Abstract: A personal surveillance system configured to be worn by an individual includes a communication system configured to record communication files, a locating system configured to determine a location of the personal surveillance system, and a transmitter configured to send the communication files and the location of the personal surveillance system to a remote monitoring station. The locating system includes a satellite system interface configured to determine the location of the personal surveillance system and an alternate positioning system configured to determine the location of the personal surveillance system in at least one situation where the satellite system interface cannot determine the location of the personal surveillance system.

Abstract: A wall and roof structure primarily for buildings that are partly under ground. In the roof structure, sheets of steel are placed in an upward concave position supported by beams and columns with compression members positioned between the beams. In the walls, a similar arrangement is used with sheets of steel in a concave outward position supported between the columns. This provides a free span suspension design with no columns or bearing walls needed inside the basic structure.

Abstract: A fall arresting ladder safety device for attachment to a fixed ladder side rail. The fall arresting device is to be used in conjunction with a body harness worn by the climber with a lanyard attached at one end to the body harness and the other end attached to the fall arresting device. The fall arresting device includes first and second arms pivotally connected in an X-configuration with each arm having first and second ladder side rail engaging portions disposed on opposite edges of the ladder side rail. A spring operably attached to the first and second arms biases the first and second arms between a fall arresting position and a climbing position. To ascend or descend the ladder, the handle portion of the first arm is pivoted upward to disengage the ladder side rail engaging portions of the first arm so that the device can be rolled up or down the ladder side rail as the climber ascends or descends the ladder.

Abstract: A mechanism for positioning a cutting and punching machine relative to a fixed conveyor for feeding material to be processed in a fixed horizontal route into the machine. The positioning mechanism comprises a carriage which supports the machine for back and forth movement laterally of the horizontal feeding route, which carriage is supported in turn on a support providing tracks for lateral movement of the carriage, with the support mounted within a lined pit. A drive unit is mounted on the machine for effecting lateral movement of the carriage, and a second drive unit is mounted within the lined pit below the support for moving the support vertically within the pit.

Abstract: A method for making small lead objects such as bullets. Lead is melted and while in a molten state is pumped through a metering device that regulates the amount fed into a die where it solidifies. Force is immediately applied to the still-soft lead to form the hard bullet.

Abstract: A method and apparatus for making small lead objects such as bullets. Lead is melted and while in a molten state is pumped through a metering device that regulates the amount fed into a die where it solidifies. Force is immediately applied to the still-soft lead to form the hard bullet.

Abstract: A ratcheting wrench having a handle configured to be engaged by the hand of the user, the handle having a top, bottom, and opposed sides, a ratchet member rotatably supported at one end of the handle having means to engage a nut or bolt to be rotated, and an endless belt carried by the handle and rotated with the ratchet member, the belt being exposed at at least one area of one side of the handle so that it may be engaged by the thumb or fingers or the user to enable the user to apply rotational torque to the ratchet member.

Abstract: A wrench and ratcheting bolt therefor, having no moving parts, said wrench having the outer periphery of one end thereof shaped in the form of a hexagon and the outer periphery of the other end shaped in the form of a pair of hexagons sharing a common side. The bolt for use with said wrench having an irregularly shaped recess in the head thereof for receiving either end of the wrench and permitting a ratcheting effect when threading or unthreading the bolt with the hexagonally shaped wrench end.

Abstract: An adjustable wrench for torqueing and ratcheting a symmetrical convex polygon member, such as a square, hexagon, or octagon, the wrench having a body with a fixed jaw and a movable jaw, one of the jaws having a torqueing are defined by intersecting torqueing surfaces which engage the planar surfaces on the member to be rotated and having also, outwardly from such torqueing surfaces, a first and second ratcheting surface for engaging adjacent surfaces on the member to be rotated, the outermost ratcheting surface being of a length less than 1/2 the length of the one side of the member to be ratcheted, and the other jaw having a member engaging area including torqueing surface corresponding to the torqueing surfaces of the first mentioned jaw and having a planar outer ratcheting surface which is parallel with the outermost ratcheting surface of the other jaw, such that the spacing between the jaws may be adjusted so that the member may be engaged between the torqueing surfaces of the two jaws for applying torqu

Abstract: A ratcheting wrench for a hexagonal member, the wrench having a body portion with a first and second jaws extending therefrom, the jaws being spaced apart from each other and providing a member receiving area therebetween, and a handle extending from the body, the first jaw having an inner peripheral surface facing the member receiving area having four contiguous torqueing surfaces configured to receive a hexagonal member, each of these torqueing surfaces being at an angle of 120.degree. relative to any adjacent torqueing surface, and the second jaw having an inner peripheral surface facing the member receiving area having four contiguous torqueing surfaces configured to receive a hexagonal member, each of the torqueing surfaces being at an angle of 120.degree. relative to any adjacent torqueing surface, the first jaw torqueing surfaces and the second jaw torqueing surfaces each being adaptable to separately contact four peripheral surfaces of a hexagonal member.