Patents by Inventor James P. O'Leary
James P. O'Leary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964989Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 20, 2022Date of Patent: April 23, 2024Assignees: Mirati Therapeutics, Inc., Array BioPharma Inc.Inventors: Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson, Matthew Arnold Marx, Christopher Ronald Smith, Shelley Allen, James F. Blake, Mark Joseph Chicarelli, Joshua Ryan Dahlke, Donghua Dai, Jay Bradford Fell, John Peter Fischer, Macedonio J. Mejia, Brad Newhouse, Phong Nguyen, Jacob Matthew O'Leary, Spencer Pajk, Martha E. Rodriguez, Pavel Savechenkov, Tony P. Tang, Guy P.A. Vigers, Qian Zhao, Dean Russell Kahn, John Gaudino, Michael Christopher Hilton
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Patent number: 9089718Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: June 18, 2014Date of Patent: July 28, 2015Assignee: CARDIAC SCIENCE CORPORATIONInventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Publication number: 20140364918Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: ApplicationFiled: June 18, 2014Publication date: December 11, 2014Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6944498Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: September 5, 2002Date of Patent: September 13, 2005Assignee: Cardiac Science, Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6546285Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: August 31, 2000Date of Patent: April 8, 2003Assignee: Cardiac Science, Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Publication number: 20030055460Abstract: A defibrillator for delivering therapeutic electrical energy to a patient's heart generally includes a power source, electrodes, a patient impedance sensor, and a controller. The electrode are capable of being applied to a patient and are operably coupled to the power source. The impedance sensor is couplable to the patient. The controller controls the power source and is communication with the patient impedance sensor. In response to the patient impedance and based thereon, the controller can configure a variety of circuit options to deliver a low current flow defibrillation waveform , which has a substantially constant tilt, to the patient.Type: ApplicationFiled: May 31, 2002Publication date: March 20, 2003Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Publication number: 20030023277Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: ApplicationFiled: September 5, 2002Publication date: January 30, 2003Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Publication number: 20030004547Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: ApplicationFiled: August 21, 2002Publication date: January 2, 2003Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6427083Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: August 31, 2000Date of Patent: July 30, 2002Assignee: Cardiac Science, Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6418342Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: August 31, 2000Date of Patent: July 9, 2002Assignee: Cardiac Science Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6374138Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: August 31, 2000Date of Patent: April 16, 2002Assignee: Cardiac Science Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6304780Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: August 31, 2000Date of Patent: October 16, 2001Assignee: Cardiac Science Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6301502Abstract: A method of treating a patient for ventricular tachycardia using a wearable defibrillator includes monitoring the patient for a predetermined condition via one or more electrodes on the defibrillator, sending a message to the patient in response to the predetermined condition, activating the defibrillator so that the defibrillator delivers defibrillation energy to the patient, and storing at least one of the results of the monitoring, sending and activating steps in a memory on the defibrillator. The method also includes downloading information stored in the memory of the defibrillator to a base station having an external interface, and transmitting the information downloaded from the memory of the base station to an external location via the external interface of the base station.Type: GrantFiled: August 31, 2000Date of Patent: October 9, 2001Assignee: Cardiac Science Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 6224379Abstract: A spinning end of a rotating instrument is used to deform an adhesive material without the adhesive material adhering to the instrument. This process is particularly suited for packing dental composites within oral cavities.Type: GrantFiled: October 2, 1998Date of Patent: May 1, 2001Assignee: Trustees of Tufts CollegeInventors: Behrouz Abedian, Livia M. Racz, James P. O'Leary, Philip L. Millstein
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Patent number: 6148233Abstract: Electrode devices optimized for long-term wear in conjunction with an external cardiac defibrillator are described. In preferred embodiments the electrode devices include electrodes that consist of multiple segments, thereby providing enhanced efficacy and impedance characteristics relative to conventionally shaped continuous electrodes. In certain embodiments the conductive surface for contacting a patient's skin of the electrodes is continuous but contains regions separated by open spaces, thereby similarly providing enhanced efficacy and impedance characteristics. The electrode devices are fabricated using materials selected to minimize skin irritation and discomfort.Type: GrantFiled: March 6, 1998Date of Patent: November 14, 2000Assignee: Cardiac Science, Inc.Inventors: James M. Owen, Randall W. Fincke, James P. O'Leary, Mark H. Totman
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Patent number: 5258015Abstract: An improved locking cap for mounting on the smooth flexible filament of a surgical fastener wherein the locking cap is of a thin flat washer-like shape with gripping elements for engaging the filament and locking the cap in position relative to the filament.Type: GrantFiled: May 3, 1991Date of Patent: November 2, 1993Assignee: American Cyanamid CompanyInventors: Lehmann K. Li, James P. O'Leary