Patents by Inventor James P. Sherbine

James P. Sherbine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
    Patent number: 7442792
    Abstract: The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: October 28, 2008
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: James P. Sherbine, Shawn K. Pack, Jaan A. Pesti, Robert E. Yule, Kenneth C. McNulty
  • Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
    Patent number: 7208596
    Abstract: The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: April 24, 2007
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: James P. Sherbine, Shawn K. Pack, Jaan A. Pesti, Robert E. Yule, Kenneth C. McNulty
  • STABLE NON-HYGROSCOPIC CRYSTALLINE FORM OF N-[N-[N-(4-(PIPERIDIN-4-YL)BUTANOYL)-N-ETHYLGLYCYL]ASPARTYL]-L-&bgr;-CYCLOHEXYL ALANINE AMIDE, INTERMEDIATES THEREOF, AND PREPARATION THEREOF AND OF ANTITHROMBOTIC AZACYCLOALKYLALKANOYL PEPTIDES AND PSEUDOPEPTIDES
    Patent number: 6753409
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-&bgr;-cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: June 22, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski
  • Process for preparing 2,4-dihydroxypyridine and 2,4-dihydroxy-3-nitropyridine
    Patent number: 6392049
    Abstract: The present invention is directed to a process for preparing 2,4-dihydroypyridine comprising heating a compound of the formula A wherein R is H, alkyl or aralkyl and phosphoric acid where the ratio of phosphoric acid to water is not less than about 27 to 1 weight %. The invention is also directed to a process for preparing 2,4-dihydroy-3-nitropyridine comprising reacting 2,4-dihydroypyridine with nitric acid. The processes of the present invention prepare intermediates which are useful in preparing compounds which are useful for treating cardiovascular disease marked by hypertension or myocardial ischeria, ameliorating ischemic injury or myocardial infarct size, or treating hyperlipidemia or hypercholesterolemia.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: May 21, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Larry K. Truesdale, James P. Sherbine, Benoit J. Vanasse
  • Process for preparing 2,4- dihydroxypyridine and 2,4- dihydroxy-3-nitropyridine
    Patent number: 6307054
    Abstract: The present invention is directed to a process for preparing 2,4-dihydroxy-pyridine comprising heating a compound of the formula A wherein R is H, alkyl or aralkyl and phosphoric acid where the ratio of phosphoric acid to water is not less than about 27 to 1 weight %. The invention is also directed to a process for preparing 2,4-dihydroxy-3-nitropyridine comprising reacting 2,4-dihydroxypyridine with nitric acid. The processes of the present invention prepare intermediates which are useful in preparing compounds which are useful for treating cardiovascular disease marked by hypertension or myocardial ischemia, ameliorating ischenic injury or myocardial infarct size, or treating hyperlipidemia or hypercholesterolemia.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: October 23, 2001
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Larry K. Truesdale, James P. Sherbine, Benoit J. Vanasse
  • Process for preparing N6-substituted adenosine derivatives
    Patent number: 6184382
    Abstract: The invention is directed to improved methods for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: February 6, 2001
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Diane C. Salazar, Walter Rodriguez, James P. Sherbine, Rick G. Woodward, Adam W. Sledeski, Matthew R. Powers, Michael K. O'Brien
  • Stable non-hygroscopic crystalline form of N-[N-[N-4-(piperidin-4-yl)butanoyl)-N-ethylglycyl] aspartyl]-L-.beta.-cyclohexyl alanine amide
    Patent number: 6153588
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta. -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula ##STR1## wherein: A, B, Z, E.sup.1, E.sup.2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 28, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, deceased, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski