Abstract: Low permeation gaskets are formed having low leak rates upon application of low stress sealing conditions. Preferred gaskets comprise a resilient core, a barrier layer having lower permeation to fluids than the core material, and a conformable outer layer for providing a seal at low load and low stress sealing conditions.

Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Abstract: Compounds having the formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Abstract: The following disclosure relates to a method of treating incontinence with a compound having a specific &agr;1A adrenoceptor profile.

Abstract: The present invention provides an isolated or purified polynucleotide that encodes human endosulfine polypeptide. Isoforms of human endosulfine are also disclosed. The invention also provides methods of making recombinant human endosulfine using the polynucleotides and host cells transformed with the polynucleotides.

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

Abstract: The following disclosure relates to a method of treating incontinence with a compound having a specific &agr;1A adrenoceptor profile.

Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Abstract: The following disclosure relates to a method of treating incontinence with a compound having a specific &agr;1A adrenoceptor profile.

Abstract: Compounds having the formula 1

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract: A variant human U7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

Abstract: The present invention provides an improved method and apparatus for uniformly treating strand-like material. The apparatus comprises a coiler head having a coiler diameter d and a conveyor belt having a belt width w, wherein the ratio of the coiler diameter d to the belt width w is from about 1.05:1 to about 1.40:1. The method comprises treating the strand-like material in such apparatus.

Abstract: A storm louver (10, 12) having a plurality of spaced blades (16a, 16b, 16c, 16d) for removing water particles from air flowing into a building or air handling equipment is disclosed. Each louver (10, 12) has an improved blade support frame (18) that permits the blades (16a, 16b, 16c, 16d) to be more quickly and easily installed in the support frame (18) and that more firmly supports the blades. A modular louver system including at least two individual louvers that can be easily connected for installation in openings of any size is also disclosed.

Abstract: A process of recycling a multicomponent mixed polymer waste material involves the steps of agglomerating the multicomponent mixed polymer waste material and spinning the agglomerate to form yarn, wherein the multicomponent mixed polymer waste material contains a blend of at least two incompatible polymers.

Abstract: A safety delineator is provided having either a conical or a tubular body portion, which has an improved handle feature permitting easy and comfortable full hand gripping of the delineator. The invention additionally solves a longstanding problem common to prior art support bases for delineators and the like, by providing a convenient handle, molded integrally with the support base element, for picking up the base. The inventive handle not only provides a convenient means for grabbing the delineator, but it also provides an additional advantage with respect to conical delineators, in that it prevents them from sticking together when they are stacked. Two types of inventive support bases are disclosed. One is a base molded from a heavy solid material, such as rubber, and includes additional advantageous features such as anti-skid grippers on the bottom surface of the base element and stacking rings molded onto the upper surface of the base element for assisting in compactly stacking a plurality of bases.

Abstract: A mounting bracket or socket for use with a flexible highway sign capable of being rolled up for storage and portability. The mounting bracket being molded from a non-rigid, elastic material that is reasonably transparent and having a socket for accommodating a frame member for the highway sign in a non-rotatable relationship. The plastic bracket including a securing platform integrally molded therewith for securing the bracket to the highway sign. A reinforcing member of substantially the same length as the mounting bracket for clamping the highway sign between the bracket and the reinforcing member. The sign engaging surfaces of the bracket and the reinforcing member each include tear resistant elements for clamping the sign to thereby transfer the sign tearing load from the fastener securing the bracket and reinforcing member to the highway sign.

Abstract: A two-piece, detachable traffic channelization element having an improved base element. The base element has a low profile, dome-like configuration with a ballast storage chamber. The storage chamber may be completely filled with a sand ballast and sealed in its storage condition by a cover secured to the chamber. The base element is molded of a resilient crush resistant plastic so that when it is fully ballasted, need not be ballasted again, and which low profile base can be traveled over by motor vehicles without engaging the base. The detached base, filled with ballast, can be continuously traveled on by motor vehicles, including loaded trucks, without damaging the base element and rendering it useless and the need to be replaced.