Patents by Inventor James R. Deason
James R. Deason has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5244899Abstract: The compounds of this invention are azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group consisting of a azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.Type: GrantFiled: July 29, 1992Date of Patent: September 14, 1993Assignee: G. D. Searle and Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 5225444Abstract: The compounds of this invention are anilides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is hydrogen or lower alkyl; and R.sub.4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.Type: GrantFiled: August 27, 1991Date of Patent: July 6, 1993Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 5219883Abstract: This invention relates to LTD.sub.4 antagonists of the formula: ##STR1## or pharmaceutically acceptable salts thereof, wherein R.sup.1 is methyl, phenyl, ##STR2## wherein X.sub.1 and X.sub.2 may be the same or different and are members of the group consisting of hydrogen, --Cl, --Br, --CF.sub.3, --NH.sub.2, --NO.sub.2, or alkyl of 1-3 carbon atoms; m is 1 to 9; n is 1 to 5; V is --CH(OH)--, or --CH.sub.2 --; W is hydrogen or alkyl of 1-6 carbon atoms; Y is hydrogen or --COCH.sub.3 provided that when W is hydrogen Y is not hydrogen; both Z moieties are --CHO, --COOR.sup.2, --COR.sup.3, --CH(OR.sup.4)--CH.sub.2 OR.sup.4, or CH.sub.2 OR.sup.4 with the exception that when one Z moiety of Formula I is COOR.sup.2, the other Z moiety may be COR.sup.3 ;R.sup.2 is hydrogen, a pharmaceutically acceptable cation, straight or branched chain alkyl having 1-6 carbon atoms, --CH.sub.2 --CH(OR.sup.5)--CH.sub.2 --OR.sup.5, CH(CH.sub.2 OR.sup.5).sub.2 with the proviso that when Z is --COOR.sup.2, the R.sup.Type: GrantFiled: November 12, 1991Date of Patent: June 15, 1993Assignee: G. D. Searle & Co.Inventors: Francis J. Koszyk, James R. Deason
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Patent number: 5198435Abstract: The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided than n+m+p is equal to or less than 10; x is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.Type: GrantFiled: March 14, 1991Date of Patent: March 30, 1993Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 5157053Abstract: The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; x is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group-consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, aszabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino, The compounds are useful as anti-inflammatory and anti-allergy agents.Type: GrantFiled: October 19, 1990Date of Patent: October 20, 1992Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 5093353Abstract: This invention relates to 2,2-di-substituted benzopyran compounds which possess leukotriene-D.sub.4 (LTD.sub.4) antagonistic activity. In particular this invention relates to LTD.sub.4 antagonists of the formula: ##STR1## or a pharmaceutically acceptable addition salt thereof, wherein R.sup.1 is methyl, phenyl, ##STR2## wherein X.sub.1 and X.sub.2 may be the same or different and are members of the group comprising hydrogen, --Cl, --Br, --CF.sub.3, --NH.sub.2, --NO.sub.2, or straight or branched chain alkyl of 1-3 carbon atoms;wherein m is an integer from 1-9;wherein n is an integer from 1-5;wherein V is >C.dbd.O, --CH(OH)--, or --CH.sub.2 --;wherein W is hydrogen or straight or branched chain alkyl of 1-6 carbon atoms;wherein Y is hydrogen or --COCH.sub.3 ;wherein Z is --CHO, --COOR.sup.2, --COR.sup.3, ##STR3## or --CH.sub.2 OR.sup.4 ; wherein R.sup.2 is hydrogen, a pharmaceutically acceptable cation, straight or branched chain alkyl having 1-6 carbon atoms, ##STR4## or --CH(CH.sub.2 OR.sup.5).sub.Type: GrantFiled: June 4, 1990Date of Patent: March 3, 1992Assignee: G. D. Searle & Co.Inventors: Francis J. Koszyk, James R. Deason
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Patent number: 5071876Abstract: The compounds of this invention are anilides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is hydrogen or lower alkyl; and R.sub.4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.Type: GrantFiled: July 27, 1990Date of Patent: December 10, 1991Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 5019597Abstract: The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.Type: GrantFiled: July 30, 1987Date of Patent: May 28, 1991Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 4950684Abstract: This invention relates to novel compounds having a 2,2-di-substituted chromanonyl (benzopyran) ring structure which are antagonists of leukotriene D.sub.4 (LTD.sub.4) and the slow reacting substance of anaphylaxis (SRS-A). The compounds of this invention are useful as pharmaceutical agents to prevent or alleviate the symptoms associated with LTD.sub.4, such as allergic reactions and inflammatory conditions.Type: GrantFiled: May 20, 1988Date of Patent: August 21, 1990Assignee: G. D. Searle & Co.Inventors: Francis J. Koszyk, James R. Deason
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Patent number: 4923891Abstract: This invention encompasses compounds of Formula I ##STR1## and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein:X, Y, and Z are each independently O or S with S optionally oxidized to S=O;Alk is straight or branched chain alkylene or hydroxyalkylene containing 1-6 carbon atoms;R.sub.1 is hydrogen or lower alkyl;n is 0 to 5;R.sub.2 is hydrogen, lower alkyl, cycloalkyl, --(CH.sub.2).sub.n --CO.sub.2 R.sub.1, phenyl, phenyl substituted with halo, lower alkyl or lower alkoxy; andAr is 5,6,7,8-tetrahydro-1-naphthalenyl, phenyl, or phenyl substituted with lower alkyl, hydroxy, lower alkoxy, or lower alkanoyl.This invention is in the field of pharmaceutical agents which act as leukotriene D.sub.4 (LTD.sub.4) antagonists and includes embodiments which act as leukotriene B.sub.4 (LTD.sub.4) antagonists.Type: GrantFiled: September 9, 1988Date of Patent: May 8, 1990Assignee: G. D. Searle & Co.Inventors: James R. Deason, Michael A. Stealey, Richard M. Weier
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Patent number: 4808729Abstract: The invention encompasses compounds of Formula I ##STR1## and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein:X, Y, and Z are each independently O or S with S optionally oxidized to S.dbd.O;Alk is alkylene or hydroxyalkylene containing 1-6 carbon atoms;R.sub.1 is hydrogen or lower alkyl;n is 0 to 5;R.sub.2 is hydrogen, lower alkyl, cycloalkyl, --(CH.sub.2).sub.n --CO.sub.2 R.sub.1, phenyl, phenyl substituted with halo, lower alkyl or lower alkoxy; andAr is 5,6,7,8-tetrahydro-1-naphthalenyl, phenyl, or phenyl substituted with lower alkyl, hydroxy, lower alkoxy, or lower alkanoyl. The compounds are useful as anti-allergy agents and anti-inflammatory agents.Type: GrantFiled: September 24, 1987Date of Patent: February 28, 1989Assignee: G. D. Searle & Co.Inventors: James R. Deason, Michael A. Stealey, Richard M. Weier
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Patent number: 4801610Abstract: Phenolic esters of the general formula I ##STR1## are useful for the prevention, management or alleviation of elastase mediated diseases or conditions.Type: GrantFiled: June 5, 1987Date of Patent: January 31, 1989Assignee: G. D. Searle & Co.Inventors: Masateru Miyano, James R. Deason
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Patent number: 4755524Abstract: The compounds of the present invention comprise substituted phenolic thioethers represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different and independently represent tert-alkyl or phenyl; A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom; B represents sulfur, sulfoxide, sulfone, oxygen, --NH-- or nitrogen substituted by alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl; C represents methylene or methylene substituted by alkyl; R.sub.3 represents CO.sub.2 H, CO.sub.2 -alkyl or a tetrazole group; m is 0 or 1, n is 2, 3 or 4 and p is 1, 2 or 3; and the pharmaceutically acceptable salts thereof.Type: GrantFiled: January 15, 1987Date of Patent: July 5, 1988Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 4711903Abstract: The compounds of the present invention comprise substituted phenolic thioethers represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different and independently represent tert-alkyl or phenyl; A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom; B represents sulfur, sulfoxide, sulfone, oxygen, --NH-- or nitrogen substituted by alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl; C represents methylene or methylene substituted by alkyl; R.sub.3 represents CO.sub.2 H, CO.sub.2 -alkyl or a tetrazole group; m is 0 or 1, n is 2, 3 or 4 and p is 1, 2 or 3; amd the pharmaceutically acceptable salts thereof.Type: GrantFiled: January 31, 1986Date of Patent: December 8, 1987Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 4683241Abstract: Phenolic esters of the general formula I ##STR1## are useful for the prevention, management or alleviation of elastase mediated diseases or conditions.Type: GrantFiled: May 21, 1984Date of Patent: July 28, 1987Assignee: G. D. Searle & Co.Inventors: Masateru Miyano, James R. Deason
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Patent number: 4663333Abstract: The compounds of this invention are acylaminoalkylpyridines representd by the formula ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk.sub.1 is straight or branched chain lower alkylene of 1 to 6 carbon atoms, R.sub.3 is lower alkyl, Alk.sub.2 is straight or branched chain alkylene of 1 to 4 carbon atoms; R.sub.4 is selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl and lower alkoxy; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.Type: GrantFiled: December 20, 1985Date of Patent: May 5, 1987Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis, James R. Deason
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Patent number: 4356184Abstract: 1-Piperidinylmethyl benzenamines represented by the formula: ##STR1## wherein X is S or --CH.sub.2 --CH.sub.2 --; R.sub.1 and R.sub.2 are the same different members of the group consisting of hydrogen or lower alkyl; and the pharmaceutically acceptable salts thereof. The compounds are useful as anti-allergic and antihypertensive agents.Type: GrantFiled: March 25, 1981Date of Patent: October 26, 1982Assignee: G. D. Searle & Co.Inventors: James R. Deason, Richard A. Partis
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Patent number: 4203989Abstract: The present invention provides Diaryl-(1-azabicyclo [2.2.2]octan-2-yl)alkanols of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R is a cycloalkanol having 4-8 carbon atoms, an alkanol having 1-2 carbon atoms, or a radical of the formula ##STR2## wherein R.sub.1 and R.sub.2 are each H or a C.sub.1 -C.sub.5 alkyl, and R.sub.3 is H or an acyl of the formula ##STR3## wherein R.sub.4 is H or a C.sub.1 -C.sub.4 alkyl. These alkanols are useful as antidiarrheal agents.Type: GrantFiled: April 30, 1979Date of Patent: May 20, 1980Assignee: G. D. Searle & Co.Inventors: Chung H. Yen, James R. Deason
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Patent number: 4035372Abstract: 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines useful by reason of their vasodilating activity are disclosed.Type: GrantFiled: August 13, 1976Date of Patent: July 12, 1977Assignee: G. D. Searle & Co.Inventors: James R. Deason, Robert W. Hamilton, Harman S. Lowrie, Kurt J. Rorig