Patents by Inventor James R. Ewing

James R. Ewing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9370316
    Abstract: The invention comprises systems, methods, and apparatus to correlate changes in MRI data with CA concentration, using an adaptive neural network In MRI techniques, CAs are used to estimate vascular properties such as blood flow, blood volume, and transfer constant of tissue microvessels However, the relationship between the contrast in the MRI image and the contrast agent concentration is not linear, instead depending on factors such as the nature of the sequence, the nature of the tissue, and the tissue concentration of contrast agent, and thus limiting the reliability of vascular properties using MRI.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: June 21, 2016
    Assignee: HENRY FORD HEALTH SYSTEM
    Inventors: James R. Ewing, Hassan Bagher-Ebadian
  • Patent number: 8989839
    Abstract: A scanning apparatus, is used to effect multiple images of a tumor in which a contrast agent has been localized as a detectable marker over a selected time to map the change in the imaged marker. The rate of change in the imaged marker and/or contrast intensity of the dyed tissues is used to assess tumor aggressiveness and as an early predictor of response to cancer therapy. In particular, following the marking of tumor or cancerous tissues by the initial localization of an imageable contrast agent, the rate of change in the volume and/or area of the imaged marker is used to provide an indication of tumor interstitial fluid pressure (TIFP).
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: March 24, 2015
    Assignees: University of Windsor, Henry Ford Hospital
    Inventors: Mordechay Schlesinger, Long Jian Liu, James R. Ewing, Stephen L. Brown
  • Publication number: 20140167756
    Abstract: A magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) probe is described that includes double containment enclosures configured to seal and contain hazardous samples for analysis. The probe is of a modular design that ensures containment of hazardous samples during sample analysis while preserving spin speeds for superior NMR performance and convenience of operation.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 19, 2014
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Herman M. Cho, Nancy M. Washton, Karl T. Mueller, Jesse A. Sears, JR., Mark R. Townsend, James R. Ewing
  • Publication number: 20140051981
    Abstract: A scanning apparatus, is used to effect multiple images of a tumor in which a contrast agent has been localized as a detectable marker over a selected time to map the change in the imaged marker. The rate of change in the imaged marker and/or contrast intensity of the dyed tissues is used to assess tumor aggressiveness and as an early predictor of response to cancer therapy. In particular, following the marking of tumor or cancerous tissues by the initial localization of an imageable contrast agent, the rate of change in the volume and/or area of the imaged marker is used to provide an indication of tumor interstitial fluid pressure (TIFP).
    Type: Application
    Filed: August 14, 2012
    Publication date: February 20, 2014
    Inventors: Mordechay Schlesinger, Long Jian Liu, James R. Ewing, Stephen L. Brown
  • Publication number: 20100198054
    Abstract: The invention comprises systems, methods, and apparatus to correlate changes in MRI data with CA concentration, using an adaptive neural network In MRI techniques, CAs are used to estimate vascular properties such as blood flow, blood volume, and transfer constant of tissue microvessels However, the relationship between the contrast in the MRI image and the contrast agent concentration is not linear, instead depending on factors such as the nature of the sequence, the nature of the tissue, and the tissue concentration of contrast agent, and thus limiting the reliability of vascular properties using MRI
    Type: Application
    Filed: May 19, 2008
    Publication date: August 5, 2010
    Inventors: James R. Ewing, Hassan Bagher-Ebadian
  • Patent number: 4585994
    Abstract: A nuclear magnetic resonance imaging system comprising a high field solenoidal magnet providing a uniform static magnetic field surrounding a subject, an RF coil surrounding the subject, a receiver coil surrounding the subject, and a cylindrical shell of magnetic material surrounding the magnet and the RF and receiver coils. The shell is positioned such that the wall thereof lies in the area of the field of the magnet where the shell's permeability is substantially at a maximum for the imposed field such that the shell functions to substantially confine the field of the magnet to an area about the shell and the environment is not adversely affected and no additional protection is required surrounding the system.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: April 29, 1986
    Assignee: Henry Ford Hospital
    Inventor: James R. Ewing