Abstract: Compositions and methods for determining an optimal dose of a medication for a subject are described that include determining the subject's genotype for the CYP2C9 and VKORC1 genes and determining the dose of the medication based on the genotype. Articles of manufacture also are provided that include polynucleotides for genotyping.

Abstract: An approved apparatus (10) for turning steerable wheels (14,16) of a vehicle includes a pinion (28) which is disposed in meshing engagement with a rack portion (32) of a steering member (12). A steering column (22) is connected with a pinion (28) and with a vehicle steering wheel (20). A ball nut assembly (38) is connected with an externally threaded portion (36) of the steering member (12). A first motor (72) is connected with the steering column (22) at a location between the pinion (28) and steering wheel (20). A second motor (48) is connected with the ball nut assembly (38). A closed loop assembly (60) may be provided to control operation of the first motor (72). An open loop assembly (82) may be provided to control operation of the second motor (48).

Abstract: A method for preventing edge chipping and cracking damage encountered by semiconductor chips in a die picking operation during separation from an adhesive sheet. Also provided is a device for preventing potential edge chipping and cracking damage encountered by a semiconductor chip during die picking processes.

Abstract: A method for forming a ceramic article useful as a bone substitute and having an outer surface defining a shape having a bulk volume and having open, interconnecting openings extending throughout the volume and opening through the surface, includes, providing an organic open-pore structure, coating surface of pores of the structure with a ceramic slip, pyrolyzing the organic structure to leave a ceramic structure having struts defining a plurality of interconnecting interstices, and providing within the interstices a porous osteoconductive composition exposed to the interconnecting openings. In a preferred embodiment, the ceramic slip includes a strong, supportive ceramic material and a separate osteoconductive material.

Abstract: Oral dosage form containing a therapeutically effective amount of a drug susceptible to abuse and an effective amount of an embolizing agent which causes the production of a solid or semi-solid embolus or blockage after tampering.

Abstract: An approved apparatus (10) for turning steerable wheels (14,16) of a vehicle includes a pinion (28) which is disposed in meshing engagement with a rack portion (32) of a steering member (12). A steering column (22) is connected with a pinion (28) and with a vehicle steering wheel (20). A ball nut assembly (38) is connected with an externally threaded portion (36) of the steering member (12). A first motor (72) is connected with the steering column (22) at a location between the pinion (28) and steering wheel (20). A second motor (48) is connected with the ball nut assembly (38). A closed loop assembly (60) may be provided to control operation of the first motor (72). An open loop assembly (82) may be provided to control operation of the second motor (48).

Abstract: Steerable vehicle wheels (12,14) are turned under the influence of force transmitted through a steering column (22). A closed loop assembly (32) is connected with the steering column (22). The closed loop assembly (22) includes a first motor (52) which is connected with a first gear unit (56). The first gear unit (56) is operated in response to the output from a first sensor (48). A feedback sensor (66) is connected with the steering column (22) adjacent to an output from the first gear unit (56). An open loop assembly (34) is connected with the steering column (22) and includes a second motor (88) which is connected with a second gear unit (92). The second motor (88) is operated in response to the output from a second sensor (82). A manual steering gear (20) is operated to turn the steerable vehicle wheels (12,14) under the influence of force transmitted from the steering wheel (18), first motor (52) and second motor (88) through the steering column (22).

Abstract: A geothermal hybrid heat exchange system is provided. The system includes a heat pump having a first fluid port and a second fluid port, a fluid reservoir, and at least one earth loop. A first end of the earth loop is connected to the first fluid port of the heat pump and the second fluid port of the heat pump and the second end of the earth loop are coupled in fluid communication with the reservoir so that fluid in the reservoir passes through the earth loop and the heat pump during heating/cooling operation of the heat pump.

Abstract: Parenteral extravascular administration of a composition containing an analgesic medication of low water solubility that is dissolved, suspended, or emulsified in a solvent system results in the deposition of the analgesic medication at the site of administration and provides a controlled release of the analgesic medication from the site and a prolonged analgesia that may persist for several days following administration.

Abstract: A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administration of the pharmaceutical formulation.

Abstract: The present invention relates to a ball joint assembly (10) including a housing (12) and a ball stud (72) disposed in the housing. The ball stud (72) has a head end portion (70) and a shank portion (74). A radial load bearing assembly (80) engages the shank portion (74) to support the ball stud (72) for movement relative to the housing (12).

Abstract: A method for preventing edge chipping and cracking damage encountered by semiconductor chips in a die picking operation during separation from an adhesive sheet. Also provided is a device for preventing potential edge chipping and cracking damage encountered by a semiconductor chip during die picking processes.

Abstract: A composite resilient scaffold may be used to grow, repair, and/or regenerate tissue such as articular cartilage. The composite scaffold is porous and at least substantially bioremovable. The composite scaffold includes a support structure coated with a discontinuous coating of separate and discrete particles of a ceramic material such as calcium phosphate. The calcium phosphate material may have a porous reticulated structure.

Abstract: A method of producing an open, porous structure having an outer surface defining a shape having a bulk volume and having interconnecting openings extending throughout said volume and opening through said surface, and products resulting from the method. The method comprises preparing a viscous mixture comprising a sinterable powder dispersed in a sol of a polymer in a primary solvent, replacing the primary solvent with a secondary liquid in which the polymer is insoluble to produce a gel comprising an open polymeric network having the sinterable powder arranged therein, removing the secondary liquid from the gel; removing the polymer network, and sintering the sinterable powder to form the open, porous structure. Also disclosed are shaped, porous products resulting from methods of the invention.

Abstract: Compositions containing a vehicle containing a rosin resin or derivative and a non-volatilized solvent or plasticizer. The compositions may be used to deliver a biologically active substance such as an active pharmaceutical ingredient. The concentration of rosin resin or derivative in the vehicle is sufficient to alter the release rate from the composition of a biologically active substance that is dissolved, dispersed, emulsified, or suspended in the vehicle.

Abstract: A graphic for application to a textile is disclosed. The graphic includes a front surface configured to be viewable when the graphic is applied to the textile. The graphic further includes a back surface opposite the front surface and configured to contact the textile. The graphic further includes an attachment mechanism, other than stitching, that attaches the graphic to the textile. The graphic also includes a simulated stitching pattern “etched” onto the front surface of the graphic extending around a perimeter of the graphic and includes projections simulating stitch ends.

Abstract: A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.

Abstract: A control system and method of controlling a propeller aircraft engine during takeoff limits the amount of engine power developed at the very beginning of the takeoff in order to maximize thrust and minimize rollout distances. The control system limits the amount of power developed by the engine, even in the face of a nominal demand by the pilot for maximum engine power. Instead, the control system provides something significantly less than full power at the beginning of takeoff and gradually increases the power developed by the engine to full power as the airspeed increases. This gradual increase from partial engine power toward full power helps prevent stalling of the propeller, thereby maximizing the effectiveness of the propeller and engine in assisting the aircraft to takeoff quickly. The control system is particularly helpful for taking off from high-altitude runways.

Abstract: A baffle is disclosed which comprises a plurality of substantially S-shaped baffle members and a frame configured to hold the baffle members substantially parallel to each other. The baffle is configured to separate one or more entrained substances from an air stream.

Abstract: Particles may be used to filter harmful biological material from an fluid stream such as air. The particles can be arranged into a bed to filter the harmful biological material from the fluid. The particles include a biocidal agent which is used to destroy the harmful biological material.