Patents by Inventor James R. Ladtkow
James R. Ladtkow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11692170Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.Type: GrantFiled: June 29, 2020Date of Patent: July 4, 2023Assignee: Terumo BCT, Inc.Inventors: James R. Ladtkow, Geoffrey M. Uhl, Jeremy P. Kolenbrander, Briden Ray Stanton
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Publication number: 20230015292Abstract: A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.Type: ApplicationFiled: September 23, 2022Publication date: January 19, 2023Inventors: James R. LADTKOW, Dennis J. HLAVINKA, Thomas J. FELT, Andrew GLOOR, Jesse JANZEN, Taylor POLODNA, Luke Edwin LADTKOW
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Patent number: 11478792Abstract: A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve.Type: GrantFiled: September 28, 2017Date of Patent: October 25, 2022Assignee: Terumo BCT, Inc.Inventors: James R. Ladtkow, Dennis J. Hlavinka, Thomas J. Felt, Andrew Gloor, Jesse Janzen, Taylor Polodna, Luke Edwin Ladtkow
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Publication number: 20200325446Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.Type: ApplicationFiled: June 29, 2020Publication date: October 15, 2020Applicant: Terumo BCT, Inc.Inventors: James R. LADTKOW, Geoffrey M. UHL, Jeremy P. KOLENBRANDER, Briden Ray STANTON
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Patent number: 10704023Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.Type: GrantFiled: September 11, 2017Date of Patent: July 7, 2020Assignee: Terumo BCT, Inc.Inventors: James R. Ladtkow, Geoffrey M. Uhl, Jeremy P. Kolenbrander, Briden Ray Stanton
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Publication number: 20180093270Abstract: A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve.Type: ApplicationFiled: September 28, 2017Publication date: April 5, 2018Applicant: Terumo BCT, Inc.Inventors: James R. LADTKOW, Dennis J. Hlavinka, Thomas J. Felt, Andrew Gloor, Jesse Janzen, Taylor Polodna, Luke Edwin Ladtkow
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Publication number: 20170369844Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: Terumo BCT, Inc.Inventors: James R. LADTKOW, Geoffrey M. UHL, Jeremy P. KOLENBRANDER, Briden Ray STANTON
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Patent number: 9758764Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.Type: GrantFiled: February 18, 2014Date of Patent: September 12, 2017Assignee: Terumo BCT, Inc.Inventors: James R. Ladtkow, Geoffrey M. Uhl, Jeremy P. Kolenbrander, Briden Ray Stanton
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Patent number: 9737898Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: GrantFiled: September 10, 2015Date of Patent: August 22, 2017Assignee: Terumo BCT, Inc.Inventors: Brian M. Holmes, James R. Ladtkow
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Patent number: 9435736Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.Type: GrantFiled: August 29, 2013Date of Patent: September 6, 2016Assignee: Terumo BCT, Inc.Inventors: Jeremy P. Kolenbrander, Brian M. Holmes, Thomas J. Felt, James R. Ladtkow
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Publication number: 20150375238Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: ApplicationFiled: September 10, 2015Publication date: December 31, 2015Applicant: TERUMO BCT, INC.Inventors: Brian M. HOLMES, James R. LADTKOW
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Patent number: 9156039Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: GrantFiled: June 12, 2012Date of Patent: October 13, 2015Assignee: Terumo BCT, Inc.Inventors: Brian M. Holmes, James R. Ladtkow
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Publication number: 20140234829Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.Type: ApplicationFiled: February 18, 2014Publication date: August 21, 2014Applicant: TERUMO BCT, INC.Inventors: James R. LADTKOW, Geoffrey M. UHL, Jeremy P. KOLENBRANDER, Briden Ray STANTON
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Publication number: 20140005023Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.Type: ApplicationFiled: August 29, 2013Publication date: January 2, 2014Applicant: Terumo BCT, Inc.Inventors: Jeremy P. KOLENBRANDER, Brian M. HOLMES, Thomas J. FELT, James R. LADTKOW
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Patent number: 8535210Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.Type: GrantFiled: December 3, 2010Date of Patent: September 17, 2013Assignee: Terumo BCT, Inc.Inventors: Jeremy P. Kolenbrander, Brian M. Holmes, Thomas J. Felt, James R. Ladtkow
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Publication number: 20120316049Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: ApplicationFiled: June 12, 2012Publication date: December 13, 2012Applicant: TERUMO BCT, INC.Inventors: Brian M. HOLMES, James R. LADTKOW
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Patent number: 8057376Abstract: A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.Type: GrantFiled: September 30, 2008Date of Patent: November 15, 2011Assignee: CaridianBCT, Inc.Inventors: James R. Ladtkow, Joseph A. Scibona, Jeremy Kolenbrander
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Publication number: 20110143905Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.Type: ApplicationFiled: December 3, 2010Publication date: June 16, 2011Applicant: CARIDIANBCT, INC.Inventors: Jeremy P. KOLENBRANDER, Brian M. HOLMES, Thomas J. FELT, James R. LADTKOW
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Patent number: 7943916Abstract: The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components with a two-dimensional optical measurement and control device. The method may comprise the steps of providing a blood processing system comprising a density centrifuge blood processing system and an elutriation blood processing system; filling the elutriation blood processing system with a desired component; measuring a cellular flux of cells entering the elutriation blood processing system with a two-dimensional optical control system; and flushing the elutriation blood processing system.Type: GrantFiled: September 17, 2009Date of Patent: May 17, 2011Assignee: CaridianBCT, Inc.Inventors: Lee F. Carter, Jeremy P. Kolenbrander, James R. Ladtkow, Joseph A. Scibona, Jeffrey A. Steward, Chris Fletcher
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Patent number: 7906771Abstract: The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. The method may include performing first and second measurements of an operating condition; analyzing the first and second measurements using a predictive data analysis algorithm; comparing the predicted operating condition to a desired operating condition; and adjusting at least one setting.Type: GrantFiled: September 17, 2009Date of Patent: March 15, 2011Assignee: CaridianBCT, Inc.Inventors: Lee F. Carter, Jeremy P. Kolenbrander, James R. Ladtkow, Joseph A. Scibona, Jeffrey A. Steward, Chris Fletcher