Patents by Inventor James R. Metcalf

James R. Metcalf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused heterocyclic compounds as RET kinase inhibitors
    Patent number: 11964988
    Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 23, 2024
    Assignee: ARRAY BIOPHARMA INC.
    Inventors: James F. Blake, Donghua Dai, Julia Haas, Yutong Jiang, Dean Kahn, Gabrielle R. Kolakowski, Elizabeth A. McFaddin, Megan L McKenney, Andrew T. Metcalf, David A. Moreno, Brett Prigaro, Ginelle A. Ramann, Li Ren, Shane M. Walls, Hailong Zhang
  • SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
    Publication number: 20240066029
    Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
    Type: Application
    Filed: June 27, 2023
    Publication date: February 29, 2024
    Inventors: Steven W. ANDREWS, Sean ARONOW, James F. Blake, Barbara J. BRANDHUBER, Adam COOK, Julia HAAS, Yutong JIANG, Gabrielle R. KOLAKOWSKI, Elizabeth A. MCFADDIN, Megan L. MCKENNEY, Oren T. MCNULTY, Andrew T. METCALF, David A. MORENO, Tony P. TANG, Li REN
  • Graphics engine for true colour 2D graphics
    Patent number: 5459823
    Abstract: A graphics engine is disclosed which can be used in a colour desktop publishing system. The graphics engine accepts 32-bit RGBM data and performs pixel level calculations under computer control to output processed 32-bit RGBM data. The engine comprises a render processor interface, a run controller including a ramp generator, and a control unit. Interpolators are provided for each colour (RGB) and cascaded with corresponding compositors. A transparency interpolator and matte combiner alter the matte plane of the video image. The engine can output data suitable for rendering by a colour laser printer for a full size A3 page at 400 dots per inch.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: October 17, 1995
    Assignees: Canon Kabushiki Kaisha, Canon Information Systems Research Australia Pty. Ltd.
    Inventors: Kia Silverbrook, James R. Metcalf