Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure.

Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure.

Abstract: A catheter assembly includes a wire guide having a helical outer wire and a non-helical core wire slidable within the outer wire between an advanced position and a retracted position. The outer wire includes a steering tip having a medium stiffness and a bending bias, and the core wire includes a higher stiffness and a straightening bias. The assembly further includes a catheter slidable over the outer wire to a steering configuration. A distal catheter end includes a compliant lower stiffness, and is adjustable in the steering configuration between a straight shape and a curved shape.

Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure.

Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure.

Abstract: A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.

Abstract: A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.

Abstract: A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.

Abstract: An occlusion device has a covering attached to a support frame that includes a disc-shaped member and a crossbar that extends across a central opening defined by the disc-shaped member. The occlusion device has a first, or deployed, configuration in which the crossbar defines a curve that extends from the disc-shaped member, and a second, or resting, configuration in which the disc-shaped member and the crossbar lie substantially in a single plane. Each of the disc-shaped member and the crossbar include a core wire that extends through a lumen of a coil multiple times.

Abstract: A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.

Abstract: A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.

Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure.

Abstract: A catheter assembly includes a wire guide having a helical outer wire and a non-helical core wire slidable within the outer wire between an advanced position and a retracted position. The outer wire includes a steering tip having a medium stiffness and a bending bias, and the core wire includes a higher stiffness and a straightening bias. The assembly further includes a catheter slidable over the outer wire to a steering configuration. A distal catheter end includes a compliant lower stiffness, and is adjustable in the steering configuration between a straight shape and a curved shape.

Abstract: A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.

Abstract: An intraluminal system for retrieving an implantable medical device from a body vessel includes, according to one embodiment, a grasping component including at least one deployable arm, where a proximal end of the arm is configured to extend away from a longitudinal axis of the system when deployed, and a first sheath disposed adjacent to the grasping component, where the first sheath includes a radially expandable portion at a distal end thereof. A second sheath overlies the first sheath and the grasping component. Relative motion between the second sheath and the grasping component allows the proximal end of the deployable arm to be deployed for grasping a distal portion of an implantable medical device, and relative motion between the second sheath and the first sheath allows the expandable portion of the first sheath to radially expand to receive a proximal portion of the implantable medical device.

Abstract: An intraluminal system for retrieving an implantable medical device from a body vessel includes, according to one embodiment, a grasping component including at least one deployable arm, where a proximal end of the arm is configured to extend away from a longitudinal axis of the system when deployed, and a first sheath disposed adjacent to the grasping component, where the first sheath includes a radially expandable portion at a distal end thereof. A second sheath overlies the first sheath and the grasping component. Relative motion between the second sheath and the grasping component allows the proximal end of the deployable arm to be deployed for grasping a distal portion of an implantable medical device, and relative motion between the second sheath and the first sheath allows the expandable portion of the first sheath to radially expand to receive a proximal portion of the implantable medical device.