Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

Abstract: A food preparation table includes a housing at least in part defining multiple food pan receiving locations and a cooling air flow path internal of the housing below the food pan receiving locations. A first food pan is positioned within a first one of the food pan receiving locations such that side walls and a bottom wall of the first food pan are within the cooling air flow path, a first one of the side walls of the first food pan includes a plurality of openings therein to permit some cooling air to enter the first food pan and flow in contact with food items therein.

Abstract: A food pan cooling system includes a housing with a food item holding arrangement including a recessed well area defining at least a first food pan receiving location and a second food pan receiving location. The first food pan receiving location includes a first cooled wall structure in the recessed well area to at least in part define the first food pan receiving location, the first cooled wall structure having a first surface facing the first food pan receiving location. A first thermal shim is connected to the first cooled wall structure, the first thermal shim having a first shim surface and a second shim surface, the first shim surface at least partly in contact with the first surface of the first cooled wall structure, and the second shim surface facing the first food pan receiving location.

Abstract: An enterprise fuel management system for managing fueling operations of an aircraft fleet operated by a fleet operator having a central computer system at a data center and operating aircraft at multiple airports avoids reliability problems associated with synchronizing a central database with local databases. Data collection units communicate collected fueling information wirelessly to a central data center, and the data collection units are not in direct communication with the fleet operator's central computer system. Moreover, the central data center gathers fueling information from the various data collection units and communicates the gathered fueling information to the fleet operator's central computer system as data messages for subsequent processing and action.

Abstract: An extended Kalman filter (EKF) is combined with a fixed epoch smoother (FES) to produce a new variable lag smoother (VLS). The fixed epoch lags EKF measurement time-tags with variable time lag. The combination of EKF and FES is referred to herein as a variable lag smoother (VLS).

Abstract: An enterprise fuel management system for managing fueling operations of an aircraft fleet operated by a fleet operator having a central computer system at a data center and operating aircraft at multiple airports avoids reliability problems associated with synchronizing a central database with local databases. Data collection units communicate collected fueling information wirelessly to a central data center, and the data collection units are not in direct communication with the fleet operator's central computer system. Moreover, the central data center gathers fueling information from the various data collection units and communicates the gathered fueling information to the fleet operator's central computer system as data messages for subsequent processing and action.

Abstract: An extended Kalman filter (EKF) is combined with a fixed epoch smoother (FES) to produce a new variable lag smoother (VLS). The fixed epoch lags EKF measurement time-tags with variable time lag. The combination of EKF and FES is referred to herein as a variable lag smoother (VLS).

Abstract: Sequential GPS Doppler carrier phase count measurements are used for precision sequential determination of position and velocity of a GPS receiver, such as for orbit determination and geolocation, with minimum throughput time. Real-time orbit determination and geolocation performance is enabled with an optimal sequential filter, and near-real-time performance is enabled with an optimal fixed-lag smoother. Many problems associated with prior art orbit determination are eliminated by addressing the “cycle slip” problem, the unknown initial range problem with RANGECP measurement representations, the problem of serial correlation in the measurements due to reprocessing of overlapping thermal noise. Also, the present invention significantly attenuates the carrier signal phase variation due to rotation of receiver antenna relative to transmitter antenna because the sequential phase count time intervals are sufficiently short.

Abstract: Sequential GPS Doppler carrier phase count measurements are used for precision sequential determination of position and velocity of a GPS receiver, such as for orbit determination and geolocation, with minimum throughput time. Real-time orbit determination and geolocation performance is enabled with an optimal sequential filter, and near-real-time performance is enabled with an optimal fixed-lag smoother. Many problems associated with prior art orbit determination are eliminated by addressing the “cycle slip” problem, the unknown initial range problem with RANGECP measurement representations, the problem of serial correlation in the measurements due to reprocessing of overlapping thermal noise. Also, the present invention significantly attenuates the carrier signal phase variation due to rotation of receiver antenna relative to transmitter antenna because the sequential phase count time intervals are sufficiently short.

Abstract: An apparatus for and a method of forming a surface finish on a top surface of a drain cover for swimming pools or spas so that the surface finish of the drain cover matches the surface finish of the pool or spa. The apparatus comprises a ring shaped structure that is adapted to be positioned on the top surface of the drain cover wherein the ring is mounted along the general outer perimeter of the top surface of the drain cover. An exposed aggregate or plaster finish is then formed on the top surface of the cover enclosed by the ring so that the ring retains and shapes the surface finish.

Abstract: In accordance with the present invention, there are provided humanized fish insulin genes. Humanized insulin the present invention encode human insulin alpha and/or beta chains while using fish-preferred codons and regulatory sequences. These humanized genes are thus expressible in fish islet cells. Also provided are transgenic fish having islet cells containing and capable of expressing humanized insulin genes. These islet cells (Brockmann Bodies) can be xenotransplanted into subjects having diabetes. In this manner normoglycemia can be achieved in the recipient of the islets.

Abstract: An apparatus for and a method of forming a surface finish on a top surface of a drain cover for swimming pools or spas so that the surface finish of the drain cover matches the surface finish of the pool or spa. The apparatus comprises a ring shaped structure that is adapted to be positioned on the top surface of the drain cover wherein the ring is mounted along the general outer perimeter of the top surface of the drain cover. An exposed aggregate or plaster finish is then formed on the top surface of the cover enclosed by the ring so that the ring retains and shapes the surface finish.

Abstract: An apparatus for and a method of forming a surface finish on a top surface of a drain cover for swimming pools or spas so that the surface finish of the drain cover matches the surface finish of the pool or spa. The apparatus comprises a ring shaped structure that is adapted to be positioned on the top surface of the drain cover wherein the ring is mounted along the general outer perimeter of the top surface of the drain cover. An exposed aggregate or plaster finish is then formed on the top surface of the cover enclosed by the ring so that the ring retains and shapes the surface finish.

Abstract: An apparatus for and a method of forming a surface finish on a top surface of a drain cover for swimming pools or spas so that the surface finish of the drain cover matches the surface finish of the pool or spa. The apparatus comprises a ring shaped structure that is adapted to be positioned on the top surface of the drain cover wherein the ring is mounted along the general outer perimeter of the top surface of the drain cover. An exposed aggregate or plaster finish is then formed on the top surface of the cover enclosed by the ring so that the ring retains and shapes the surface finish.

Abstract: An apparatus for and a method of forming a surface finish on a top surface of a drain cover for swimming pools or spas so that the surface finish of the drain cover matches the surface finish of the pool or spa. The apparatus comprises a ring shaped structure that is adapted to be positioned on the top surface of the drain cover wherein the ring is mounted along the general outer perimeter of the top surface of the drain cover. An exposed aggregate or plaster finish is then formed on the top surface of the cover enclosed by the ring so that the ring retains and shapes the surface finish.

Abstract: This invention relates to transgenic fish containing a humanized insulin gene which has been altered to secrete human insulin and its use in the treatment of diabetes. In the transgenic fish of the present invention, the fish insulin gene has been modified to code for human insulin gene while leaving the regulatory sequences of fish insulin gene intact. Islet transplantation may provide the meticulous glycemia control required in the treatment of diabetes. The islet tissue of the present invention offers an inexpensive and a nearly unlimited supply of human insulin-producing tissue and therefore, may be useful in the treatment of diabetes. In this regard, an improved method of mass isolation of islet tissue is provided by the present invention. The present invention also provides the use of the humanized insulin gene to promote growth in fish.

Abstract: The invention relates to a semi-permanent backshell and connector assembly for use with a harness having a plurality of conductors. More particularly, the invention relates to a connector and backshell assembly that inhibits unauthorized service and repair. The invention comprises a connector, an annular adapter sleeve, and a backshell. The adapter sleeve defines a locking surface that has at least on dog extending therefrom. The dog engages tooth-like projections on the connector. The adapter sleeve can rotate relative to the cylindrical extension before the backshell is installed due to the at least one dog being displaceable away from the tooth-like projections, and the adapter sleeve cannot rotate relative to the cylindrical extension after the backshell is installed due to the stopping surface preventing the at least one dog from displacing away from the tooth-like projections.

Abstract: An electrical connector segment, for use in industrial and transportation application, which provides engagement to another complementary coupler segment with fine incremental adjustment and prevents disengagement from vibration, jarring and shock and by those unfamiliar with its function, including a backshell assembly for joining an electrical cable to the connector segment, with the same features plus means by which ready access is provided to the juncture, of the wire leads of the cable, with the connector elements within the connector segment for maintenance, repair and modification.

Abstract: A fiber optic harness assembly having reduced weight and bulk comprises a plurality of optical fibers and loose tube protective buffers therefor. At least two of the optical fibers and corresponding buffers are routed commonly along a first branch of the harness and respectively along the second and third branches of the harness. Similarly, strength elements extending parallel to corresponding optical fibers are routed commonly along the first branch to the intersection whereat the strength elements are divided into separate portions for extension respectively along the second and third branches. The strength elements and buffered optical fibers coextending along the harness branches are surrounded and held bundled together in contiguous relationship by respective branch portions of an outer jacket or sheath.

Abstract: A connector device and method of use thereof provide positioning and hermetic sealing of electrical contacts in protective housings. The housings protect wires which connect the speed sensor of a turbine engine to a display. The connector supports the electrical contacts in an electrical insulator. The connector includes a malleable flange which is adapted to be hermetically sealed between two housings which protect wires connected to the speed sensor in the turbine engine. The flange is hermetically sealed between a tongue on one housing and a groove in the other housing. The sealing flange extends radially from the central axis of the connector and is compressed by the tongue of a releasable housing into the groove of a permanent housing to form a hermetic seal. The flange supports the electrical insulator which holds electrically conducting inner contacts in position to be slideably mounted into outer contacts which are supported by the connector housing.