Abstract: According to one aspect of the invention, a gaming machine for conducting a wagering game, comprising a physically configurable button panel and at least one mechanical button removably disposed in the button panel. The gaming machine also comprises an input panel disposed adjacent to the button to produce an output signal in response to a predetermined movement of the button and a controller for initiating a function in response to the output signal.

Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

Abstract: A gaming machine for conducting a wagering game includes a player-actuated button containing a representation of a variable dice outcome affecting events in the wagering game.

Abstract: The present invention provides isolated peptides relating to the autoimmune disease pemphigus vulgaris. The peptides relating to pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.

Abstract: A gaming machine for conducting a wagering game includes a player-actuated button containing multicolored or multiple LEDs of varied colors for representing denominations, play modes, or values in a wagering game.

Abstract: The present invention provides isolated peptides relating to the autoimmune disease Pemphigus vulgaris. The peptides relating to Pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.

Abstract: A gaming machine for conducting a wagering game includes a value input device for receiving a wager and at least one rotatable reel. The reel comprises a reel strip arranged about the periphery of a cage. The reel strip comprises an alterable film for displaying a plurality of symbols. The gaming machine further comprises a controller operative to alter the appearance of at least one of the plurality of symbols displayed on the film.

Abstract: A gaming machine controlled by a processor in response to a wager comprises a main display, a secondary display, and a touch screen assembly overlying the secondary display. The secondary display touch screen assembly has an inner bezel frame, an insulated touch screen, a panel having an opening, and an outer bezel frame. The insulated touch screen ha an insulating material around a periphery of the touch screen. The insulated touch screen is positioned within the opening of the panel. The panel and the insulated touch screen are positioned between the inner bezel frame and the outer bezel frame.

Abstract: The present invention provides isolated peptides relating to the autoimmune disease pemphigus vulgaris. The peptides relating to pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.

Abstract: An electromechanical coin sound simulator in a gaming machine having a controller, is disclosed. The generated coin sound may be used as a sound effect during game play or may be used to audibly signify a coin award associated with a winning game outcome. The electromechanical coin sound simulator includes a motor coupled to the controller, and an arm assembly activated for rotative movement by the motor. The arm assembly includes portions adapted to strike an interior area of the gaming machine to generate the coin sound. The arm assembly may be a multilink arm assembly, a single link arm assembly, or a spring loaded arm assembly. The electromechanical coin sound simulator may also be configured with a solenoid assembly, belt-feeding coin conveyor assembly, or a disc-feeding coin conveyor assembly, to name a few.

Abstract: A method and system to reduce vibration in a turbine-generator including measuring a magnitude of radial vibration of a turbine shaft with at least one vibration sensor configured to generate a vibration signal indicative of vibration frequency; measuring a generator power output with a power output sensor configured to generate a generator power output signal; detecting vibration frequencies in a rough load zone range; engaging an air injection means when a magnitude of radial vibration detected in the rough load zone range is above a predetermined threshold; storing a generator power output level as a reference level when engaging the air injection means; and disengaging the air injection means when either the measured generator power output exceeds a predetermined level or the measured generator power output differs from the reference level by a predetermined amount.

Abstract: Recombinant enzymatically active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.

Abstract: Recombinant enzymatically active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.

Abstract: A gaming machine includes a coin input device for receiving coins that can be used to play a wagering game. The coin input device includes a coin control mechanism and a coin validation component downstream from the coin control mechanism. The coin control mechanism slows the velocity and properly spaces the coins to prevent jamming and to allow the coin validation component to accurately identify the currency value and authenticity of each coin.

Abstract: A lifting apparatus for manipulating manhole castings and the like having at least one pinch clamp with an inner leg and an outer leg opposing one another wherein the inner leg and the outer leg are engageable with the manhole casting. A foot of the pinch clamp is connected to at least one of the inner leg and the outer leg wherein the foot is wider than the width of the inner leg and the outer leg and is engageable with the manhole casting. A flexible support is pivotally connected to the pinch clamp and is connectable to a lifting device wherein the foot and the legs of the pinch clamp are engageable with the manhole casting when the flexible support is pulled taut. Preferably, the inner and outer legs are separate structures pivotally connected thereto. Alternatively, the inner and outer leg may be integrally fabricated from a one-piece structure. The flexible supports are connected to a connector which is connectable to a lifting device.

Abstract: Recombinant enzymatically active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.

Abstract: Recombinant active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.

Abstract: Recombinant enzymatically active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.

Abstract: A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions.

Abstract: A liquid monitoring system includes chamber structure with a monitoring region in which the liquid to be monitored is disposed, the monitoring region having two spaced wall portions and a supplemental wall portion. The system further includes a radiation source mounted adjacent one of the spaced wall portions or directing a beam of radiation along a horizontal path, and a sensor mounted adjacent the opposed wall portion for receiving radiation in a beam path. The incident radiation beam as it passes through the wall into the monitoring region is refracted at the region surface as a function of gas or liquid within the region. At a first refracting angle, the refracted beam impinges on the supplemental wall and is internally reflected, the reflected radiation passing along a reflected beam path and sensed by the detector to provide an indication of the fluid in the chamber. At a second refracting angle, the refracted beam is not reflected in a direction such that radiation from the source is sensed.