Abstract: A series of heteroaryl-substituted fused pyridine derivatives, in particular heteroaryl-substituted thieno[3,2-6]pyridine derivatives, being selective inhibitors of PO kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A modulator is disclosed for creating a pressure pulse in a fluid-filled well. The modulator comprises a tool body on which a plurality of extendable arms are mounted. The arms may be retracted into a stowed position substantially adjacent the tool body, or may be extended to meet the wall of the borehole. The arms are preferably resilient bowsprings that may be flexed outwards from the tool by means of an actuator pushing on at least one end of the springs. A flexible valve sleeve or bag is suspended between the arms and cooperates with a valve mounted adjacent the sleeve on the tool body. The valve sleeve creates a fluid-flow path through the valve, and in operation, the valve closes one end of the valve sleeve to create the pressure pulse. Sealing of the valve sleeve against the wall of the well is a result of the fluid pressure inflating the sleeve against the well wall. As a result, sealing takes place over an extended area of the bag and is dynamically responsive to changes in fluid flow or pressure.

Abstract: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions, said substituted derivatives having the general formula

Abstract: A subsea system comprises a wellbore within a reservoir, equipment downstream of the wellbore, and a barrier connected to the equipment. The equipment is rated for a maximum pressure that is less than a maximum reservoir pressure and equal to or greater than the maximum reservoir pressure less external hydrostatic pressure experienced by the equipment. The barrier is rated for a maximum pressure that is equal to or greater than the maximum reservoir pressure.

Abstract: A series of heteroaryl-substituted fused pyridine derivatives, in particular heteroaryl-substituted thieno[3,2-6]pyridine derivatives, being selective inhibitors of PO kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A method of answering a query includes deconstructing documents into path segments. Identical path segments from different documents are arranged contiguously to form a set of partitions, where each partition has identical path segments. The structure of a query is then analyzed to find a match with a document. Based upon the analysis, a sub-set of partitions is selected for searching. Content from the query is compared to content within the sub-set of partitions to identify matched content. The matched content has associated structural attributes. The matched content structural attributes are compared to the structure of the query to identify an answer to the query.

Abstract: A modulator is disclosed for creating a pressure pulse in a fluid-filled well. The modulator comprises a tool body on which a plurality of extendable arms are mounted. The arms may be retracted into a stowed position substantially adjacent the tool body, or may be extended to meet the wall of the borehole. The arms are preferably resilient bowsprings that may be flexed outwards from the tool by means of an actuator pushing on at least one end of the springs. A flexible valve sleeve or bag is suspended between the arms and cooperates with a valve mounted adjacent the sleeve on the tool body. The valve sleeve creates a fluid-flow path through the valve, and in operation, the valve closes one end of the valve sleeve to create the pressure pulse. Sealing of the valve sleeve against the wall of the well is a result of the fluid pressure inflating the sleeve against the well wall. As a result, sealing takes place over an extended area of the bag and is dynamically responsive to changes in fluid flow or pressure.

Abstract: A subsea system comprises a wellbore within a reservoir, equipment downstream of the wellbore, and a barrier connected to the equipment. The equipment is rated for a maximum pressure that is less than a maximum reservoir pressure and equal to or greater than the maximum reservoir pressure less external hydrostatic pressure experienced by the equipment. The barrier is rated for a maximum pressure that is equal to or greater than the maximum reservoir pressure.

Abstract: The present invention concerns compounds of general formula (I): in which the substituents are as described herein.

Abstract: A method of answering a query includes deconstructing documents into path segments. Identical path segments from different documents are arranged contiguously to form a set of partitions, where each partition has identical path segments. The structure of a query is then analyzed to find a match with a document. Based upon the analysis, a sub-set of partitions is selected for searching. Content from the query is compared to content within the sub-set of partitions to identify matched content. The matched content has associated structural attributes. The matched content structural attributes are compared to the structure of the query to identify an answer to the query.

Abstract: Enamine derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in, which Ar1 is an aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an arylene or heteroarylene group and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(Rw) group; Rx is a oxo, thioxo, or imino group; Rw and Rz is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.

Abstract: Enamine derivatives of formula (1) are described: 1

Abstract: Enamine derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which Ar1 is an aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an arylene or heteroarylene group and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(Rw) group; Rx is a oxo, thioxo, or imino group; Rw and Rz is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.

Abstract: Enamide derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in which Ar1 is an optionally substituted aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an optionally substituted arylene or heteroarylene group and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or  in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; X is an O or S atom or the group NR30 group; j and k is each zero or the integer 1 or 2 provided that the sum of j and k is zero or the integer 1 or 2; Cy1 is an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof.

Abstract: Enamide derivatives of formula (1) are described: 1

Abstract: Enamine derivatives of formula (1) are described: 1

Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.

Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.

Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.