Abstract: A rechargeable battery assembly includes a rechargeable battery having a positive terminal and a negative terminal, and a rigid electrically conductive frame electrically connected to at least one of the positive terminal or the negative terminal of the rechargeable battery. The rigid electrically conductive frame is bent along multiple axes and includes a plurality of conductive frame members that are mechanically coupled together. The rigid electrically conductive frame surrounds the rechargeable battery on at least five sides, thereby providing structural stability to the rechargeable battery assembly during storage and use.

Abstract: A process is disclosed for creating a print profile to control the operation of a direct-to-shape printing system for applying images on the exterior of an axially symmetrical media object that has a contoured, varying exterior surface, such as occurs on curved wine bottles and sports equipment like bats. The process takes a media recipe holding media geometry information and an image intended to be printed and processes that information to control a motion control subsystem and a print engine subsystem. The geometry information is manipulated to generate a CAM table suitable for the motion control subsystem, and the image file is processed to create a raster image file suitable for ink head expression. Various setup values are included in the process to prepare the direct-to-shape printing system for use of the media recipe.

Abstract: Described herein are pharmaceutical compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto. Also described are compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof and 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4?-piperidine]-1?-carbonyl)-6-methoxypyridin-2-yl)benzoic acid, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto.

Abstract: The present invention provides methods of treating an immune system dysfunction or conditions associated with soluble BCMA using gamma secretase modulators or inhibitors in order to both restore immune function and improve the efficacy of therapies directed against BCMA present on the pathogenic B cell.

Abstract: A series of substituted dicyclopropyl methyl derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: A microparticle filter suitable for filtering microparticles from effluent from a textile treatment apparatus. The filter comprises a filter chamber comprising chamber walls, an inlet and an outlet. The filter also comprises a filter medium contained within the filter chamber. The filter medium is configured to filter microparticles from the effluent forming a filter residue and providing a filtered effluent to the outlet. The filter comprises a filter residue collection chamber located external to the filter chamber, and a filter residue removal apparatus. The chamber walls comprise an opening and a moveable member movable between a first and a second configuration; wherein: in the first configuration the moveable member cooperates with the chamber walls to seal the filter chamber so entry of the effluent into the filter chamber is through the inlet only and exit of the filtered effluent from the filter chamber is through the outlet only.

Abstract: A rechargeable battery jump starting device and a rechargeable battery assembly for use in the portable rechargeable battery jump starting device. The portable rechargeable battery jump starting device maximizes the power conducted from the rechargeable battery assembly to a battery being jump started.

Abstract: A rechargeable battery jump starting device with a discharged battery pre-conditioning system to facilitate boosting the discharged battery to jump start a vehicle or equipment engine. The pre-conditioning increases the operating voltage to the discharged battery during the pre-conditioning phase.

Abstract: A rechargeable battery jump starting device with a leapfrog charging system. The leapfrog charging system, for example, can sequentially charge multiple batteries of the rechargeable battery jump starting device.

Abstract: A jump starting apparatus for boosting or charging a depleted or discharged battery having a positive polarity battery terminal and a negative polarity battery terminal includes a rechargeable battery, an output port, a battery cable assembly, and a safety control system or circuit.

Abstract: Provided is a trailer breakaway device for use with a vehicle/trailer having a vehicle/trailer brake, a vehicle/trailer electrical power supply, and a vehicle/trailer electrical ground, the trailer breakaway device including one or more rechargeable lithium battery cells; a battery management system (BMS) connected to the one or more rechargeable lithium battery cells; a charger connect to the vehicle/trailer power supply, the charger configured to receive power from the vehicle/trailer power supply; a current limiter connected to the one or more rechargeable lithium battery cells; and a breakaway switch connected to the current limiter.

Abstract: Embodiments of the invention provide a customizable bicycle saddle for a bicycle. The bicycle saddle has been designed to allow it to be adjusted to match the ischial tuberosities of each rider's pelvis in order to minimize the pressure placed on other portions of the rider's body while seated on the bicycle. The bicycle saddle comprises a first seating portion that has been configured to allow a rider to sit on the bicycle, a second seating portion that has been configured to allow the rider to sit on the bicycle. The bicycle saddle also includes a first adjustment means configured to allow the first seating portion to be moved closer to the second seating portion, and a second adjustment means configured to allow the saddle to be moved closer to a forward portion on the bicycle.

Abstract: A method is disclosed to provide a DTS machine that is simple to operate and can through human operator control provide economic and competitive throughput speeds as compared to more complex DTS machines utilizing multiple printing tunnels and material handlers. The present method repositions a print carriage and a reconfigures an inkjet printhead bank to accommodate different sizes and shapes of media. The allows for the printing of a single piece of media in a single each printing event, but maintains a printing throughput similar to DTS machines having the capability to print media in parallel printing events. Media is moved from a media loading area on the machine by a single operator into a printing tunnel and then the operator adjusts the angle of the media relative to a reconfigurable array of ink-heads to meet inkjet expression distance requirements.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: A rechargeable battery jump starting device and a battery frame for use in an electronic device such as a portable rechargeable battery jump starting device. The rechargeable battery jump starting device maximizes the power conducted from the rechargeable battery to a battery being jump started.