Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: A panel system includes a chassis holding one or more tray arrangements, which are each configured to receive one or more cassettes at two or more bays. The tray arrangements and cassettes cooperate to define a cassette sensor arrangement and a port occupancy sensor arrangement having separate interface points. The cassette sensor arrangement may include electronic memory storing physical layer information about the cassette. All active components of the port occupancy sensor arrangement are disposed on the tray while the electronic memories of the cassette sensor arrangement are stored on the cassettes.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: A binaural hearing system includes a first hearing device and a second hearing device, each of which comprising: an input transducer; a transducer audio signal processor configured to provide a processed input transducer audio signal; an ear canal microphone; an ear canal audio signal processor configured to provide a processed ear canal audio signal; a first signal combiner configured to combine the processed input transducer audio signal with the processed ear canal audio signal to obtain an output transducer audio signal; a signal level detector configured to determine a signal level of (1) the output transducer audio signal or (2) an audio signal included in formation of the output transducer audio signal; and an output transducer; wherein the binaural hearing system further comprises a binaural excessive level detector connected to the first hearing device's signal level detector and the second hearing device's signal level detector.

Abstract: An ear tip made partially of a secondary insert, clamp, sleeve band or other memory retaining elastic material that, when integrated with a biocompatible, soft, highly elastic and vibration and sound damping material provides improved containment and isolation of sound pressure within a sound transmission path and provides the necessary retention for this type of acoustically superior material to be retained properly on a sound generating assembly.

Abstract: An earmold for an ear canal of a user, the earmold having an earmold shell and extending along an axis, the earmold shell having a tip end, the tip end facing a tympanic membrane of the user when worn by the user, the earmold includes: a first microphone connected to a first microphone opening for receiving sound in the ear canal, wherein the first microphone opening is arranged in a first position at a first distance from the tip end of the earmold shell; and a receiver opening for providing sound in the ear canal, wherein the receiver opening is arranged in a second position at a second distance from the tip end of the earmold shell; wherein the first position is different from the second position.

Abstract: An ear tip made partially of a secondary insert, clamp, sleeve band or other memory retaining elastic material that, when integrated with a biocompatible, soft, highly elastic and vibration and sound damping material provides improved containment and isolation of sound pressure within a sound transmission path and provides the necessary retention for this type of acoustically superior material to be retained properly on a sound generating assembly.

Abstract: An earmold for an ear canal of a user, the earmold having an earmold shell and extending along an axis, the earmold shell having a tip end, the tip end facing a tympanic membrane of the user when worn by the user, the earmold includes: a first microphone connected to a first microphone opening for receiving sound in the ear canal, wherein the first microphone opening is arranged in a first position at a first distance from the tip end of the earmold shell; and a receiver opening for providing sound in the ear canal, wherein the receiver opening is arranged in a second position at a second distance from the tip end of the earmold shell; wherein the first position is different from the second position.

Abstract: A hearing aid includes an ambient microphone configured to receive and convert environmental sound into an electronic input signal, a hearing loss processor configured to compensate the electronic input signal in accordance with a hearing loss of a user of the hearing aid, and to generate an electronic output signal, a receiver, an ear canal microphone configured for converting ear canal sound pressure including subsonic energy into an ear canal signal, an occlusion suppressor connected for reception and processing of the ear canal signal, and for transmitting an occlusion suppression signal, a signal combiner configured for combining the occlusion suppression signal and the electronic output signal to form a combined signal, and for transmitting the combined signal to the receiver, and a subsonic filter for filtering subsonic energy, wherein the receiver is configured to receive the combined signal, and convert the combined signal into an acoustic output signal.

Abstract: A hearing aid includes an ambient microphone configured to receive and convert environmental sound into an electronic input signal, a hearing loss processor configured to process the electronic input signal in accordance with a hearing loss of a user, and generate an electronic output signal, a receiver, an ear canal microphone configured for converting ear canal sound pressure into an ear canal signal, an occlusion suppressor for reception and processing of the ear canal signal and for transmitting an occlusion suppression signal, and a signal combiner configured for combining the occlusion suppression signal and the electronic output signal to form a combined signal, and for transmitting the combined signal to the receiver, wherein the receiver is configured to receive the combined signal, and convert the combined signal into an acoustic output signal, and wherein the receiver has a frequency response with a lower cut-off frequency that is less than 40 Hz.

Abstract: A hearing aid includes an ambient microphone configured to receive and convert environmental sound into an electronic input signal, a hearing loss processor configured to compensate the electronic input signal in accordance with a hearing loss of a user of the hearing aid, and to generate an electronic output signal, a receiver, an ear canal microphone configured for converting ear canal sound pressure including subsonic energy into an ear canal signal, an occlusion suppressor connected for reception and processing of the ear canal signal, and for transmitting an occlusion suppression signal, a signal combiner configured for combining the occlusion suppression signal and the electronic output signal to form a combined signal, and for transmitting the combined signal to the receiver, and a subsonic filter for filtering subsonic energy, wherein the receiver is configured to receive the combined signal, and convert the combined signal into an acoustic output signal.

Abstract: A hearing aid includes an ambient microphone configured to receive and convert environmental sound into an electronic input signal, a hearing loss processor configured to process the electronic input signal in accordance with a hearing loss of a user, and generate an electronic output signal, a receiver, an ear canal microphone configured for converting ear canal sound pressure into an ear canal signal, an occlusion suppressor for reception and processing of the ear canal signal and for transmitting an occlusion suppression signal, and a signal combiner configured for combining the occlusion suppression signal and the electronic output signal to form a combined signal, and for transmitting the combined signal to the receiver, wherein the receiver is configured to receive the combined signal, and convert the combined signal into an acoustic output signal, and wherein the receiver has a frequency response with a lower cut-off frequency that is less than 40 Hz.

Abstract: A plug valve assembly having an inlet and an outlet comprises a housing including a bore extending through the housing between the inlet and the outlet and a cavity intersecting the bore, a plug mounted in the cavity for rotation between first and second positions. In the first position an orifice extending through the plug is aligned axially with the bore of housing to allow fluid to flow from the inlet to the outlet and in the second position fluid is prevented from flowing from the inlet to the outlet. Seals are located in the cavity between the plug and an inner surface of said cavity and a plug retaining member is releasably attachable to the housing. A surface of the plug retaining member limits upward movement of the plug in the housing. The housing includes a reinforcement collar extending around the inner surface of the cavity.

Abstract: A plug valve assembly having an inlet and an outlet comprises a housing including a bore extending through the housing between the inlet and the outlet and a cavity intersecting the bore, a plug mounted in the cavity for rotation between first and second positions. In the first position an orifice extending through the plug is aligned axially with the bore of housing to allow fluid to flow from the inlet to the outlet and in the second position fluid is prevented from flowing from the inlet to the outlet. Seals are located in the cavity between the plug and an inner surface of said cavity and a plug retaining member is releasably attachable to the housing. A surface of the plug retaining member limits upward movement of the plug in the housing. The housing includes a reinforcement collar extending around the inner surface of the cavity.

Abstract: A tyre for a vehicle wheel comprising two sidewalls, a tread, beads, the sidewall intended to be positioned on the interior side of the vehicle being shorter than that intended to be positioned on the exterior side of the vehicle, a reinforcement structure extending between the beads and maintained in said beads by anchoring zones, each of the beads comprising a specific and distinct arrangement of the anchoring zone thereof, such that the anchoring zone of the bead intended to be positioned on the exterior side of the vehicle exhibits a greater anchoring capacity than the anchoring zone of the bead intended to be on the interior side of the vehicle. The internal and external anchoring zones are thus arranged in such a manner as to produce, in operation, a rim clamping load which is substantially identical on each side.

Abstract: Vehicle tire including two sidewalls, beads which include a seat and an external flange which are intended to come into contact with a suitable rim, and a carcass reinforcement structure. At least one bead comprises a circumferential cord structure distributed in two regions, and an anchoring region in which the reinforcement structure is anchored in the bead, that region including circumferential cords arranged as stacks distributed symmetrically on opposite sides of the reinforcement structure. The center of inertia of the bead is located in the immediate vicinity of the anchoring region.

Abstract: A tire comprising two sidewalls, beads, a reinforcement structure extending radially from each of the beads towards the crown zone, at least one of said beads comprising: a bead seat of inverted type; an anchoring zone for the reinforcement structure in said bead, comprising an arrangement of circumferential cords, a bonding mix being arranged between the circumferential cords and the reinforcement structure, said bonding mix of the anchoring zone having a elasticity modulus at a deformation of 10% of less than 20 MPa and preferably between 10 and 20 MPa; an axially outer zone arranged in the zone of the bead; a bearing zone for said bead. The anchoring rubber mix makes it possible, in spite of its rigidity which is very much less than what was advocated previously, to retain very satisfactory endurance properties.

Abstract: A delaminated talc has a plurality of high aspect ratio, smooth surface particles. The aspect ratio of the particles is determined by dividing their extent along an upper surface thereof by their thickness. The upper surface is substantially parallel to the lamellar interface direction and the thickness is measured perpendicularly to the interface direction. The upper, lower and side surfaces of the particles are smooth, lacking acute angularity and staircase effect which give rise to increased coefficient of friction and light scattering. The talc is especially suitable in cosmetic and pharmacologic preparations due to its high degree of transparency, skin adhesiveness, lubricity and spreadability.