Patents by Inventor James S. Ireland

James S. Ireland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Single nucleotide polymorphisms in genes
    Patent number: 6727063
    Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis. A role for the thrombospondin gene(s) in vascular disease is also disclosed. Use of single nucleotide polymorphisms in the thrombospondin gene(s) for diagnosis, prediction of clinical course and treatment response, development of therapeutics and development of cell-culture-based and animal models for research and treatment are disclosed.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: April 27, 2004
    Assignees: Millennium Pharmaceuticals, Inc., Whitehead Institute for Biomedical Research
    Inventors: Eric S. Lander, Michele Cargill, James S. Ireland, Stacey Bolk, George Q. Daley, Jeanette J. McCarthy
  • Coding sequence polymorphisms in vascular pathology genes
    Patent number: 6692909
    Abstract: The invention provides nucleic acid segments of the human genome, particularly necleic acid segments from the coding region of a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: February 17, 2004
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Eric S. Lander, George Q. Daley, Michele Cargill, James S. Ireland, Steven G. Rozen
  • Generic SBE-FRET protocol
    Patent number: 6642001
    Abstract: The present invention is drawn to methods for detection, quantitation and analysis of nucleotides of interest in nucleic acid sequences of interest using single base extension and fluorescence resonance energy transfer and generic donor molecule-labeled detection probes.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: November 4, 2003
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Stacey Bolk, Joel N. Hirschhorn, James S. Ireland, Eric S. Lander
  • Human single nucleotide polymorphisms
    Publication number: 20030039973
    Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from genes including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.
    Type: Application
    Filed: July 24, 2001
    Publication date: February 27, 2003
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Michele Cargill, James S. Ireland, Eric S. Lander
  • Human single nucleotide polymorphisms
    Publication number: 20020037508
    Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from genes including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.
    Type: Application
    Filed: January 18, 2001
    Publication date: March 28, 2002
    Inventors: Michele Cargill, James S. Ireland, Eric S. Lander
  • Human single nucleotide polymorphisms
    Publication number: 20020032319
    Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from genes including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.
    Type: Application
    Filed: March 7, 2001
    Publication date: March 14, 2002
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Michele Cargill, James S. Ireland, Eric S. Lander
  • Waste material digesters
    Patent number: 4138333
    Abstract: The specification discloses an improved form of waste digester in which agitator screws are separately adjustable for speed and for angular position forward and to one side. Speed control and retraction of the probes from the digesting mass are also disclosed.
    Type: Grant
    Filed: May 16, 1977
    Date of Patent: February 6, 1979
    Assignee: The Fairfield Engineering Company
    Inventors: Milo F. Arms, James S. Ireland