Abstract: Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: A refrigerated shipping container is disclosed. The container has a rigid support structure surrounding the walls thereof. The floor, roof, endwall, door assemblies and sidewalls are made from a light, non-metal, highly insulative material. These components generally comprise two relatively thin sheets of the insulative material separated by support channels. The cavities between the sheets are filled with foam insulation. Reinforcing rods may also be utilized to pre-load the structure before packing the cargo in the container. The walls, floor, door assemblies, and roof are assembled on the metal structure such that no support surface of the structure extends from inside the container to the outside.

Abstract: A non-mechanical refrigeration system particularly for use in a large insulated container such as a truck or railroad car for maintaining perishables at a desired low temperature during shipment. A cryogenic material such as liquid CO.sub.2 is used in a plurality of modes to permit or prevent exposure of the foodstuffs to CO.sub.2 vapors.

Abstract: A compact but high volume displacement, relatively noiseless and vibration free compressor for refrigeration gas or the like combining a rotary drive input with six cylinders and three reciprocating pistons within a rotor housed in a stator.