Patents by Inventor James Sillibourne

James Sillibourne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid construct
    Patent number: 11959084
    Abstract: The present invention provides a nucleic acid construct comprising: a first nucleotide sequence of interest (NOI1); a frame-slip motif or a translational readthrough motif (FSM/TRM); and a second nucleotide sequence of interest (NOI2). The invention also provides vectors and cells expressing such a construct. The invention also provides a method for modulating the relative expression of two transgenes in a nucleic acid construct which comprises the step of including a frame-slip motif or a translational readthrough motif between the two transgenes in order to reduce the expression of the downstream transgene.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: April 16, 2024
    Assignee: AUTOLUS LIMITED
    Inventors: Shaun Cordoba, James Sillibourne, Martin Pulé
  • CAR T-cells comprising transcriptional circuits
    Patent number: 11851672
    Abstract: The present invention provides a kit of vectors for transducing an immune cell with multiple transgenes comprising: (i) a first vector which comprises a first transgene and a nucleotide sequence encoding a transcription factor and; and (ii) a second vector which comprises a second transgene wherein expression of the second transgene within a host cell is dependent upon expression of the transcription factor.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: December 26, 2023
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, James Sillibourne, Shaun Cordoba
  • METHOD
    Publication number: 20230256093
    Abstract: The present invention provides a method for treating a solid cancer which comprises the step of administering a cell to a subject, wherein the cell comprises a nucleic acid sequence encoding interleukin 12 (IL-12) downstream of a frame-slip motif (FSM) or a translational readthrough motif (TRM).
    Type: Application
    Filed: May 12, 2021
    Publication date: August 17, 2023
    Inventors: Marco Della Peruta, Matteo Righi, Giulia Agliardi, Martin Pulé, Shaun Cordoba, James Sillibourne
  • Cell
    Patent number: 11643453
    Abstract: The present invention provides a cell which comprises; (i) a chimeric antigen receptor (CAR) or a transgenic T-cell receptor (TCR); and (ii) a polypeptide capable of co-localizing a beta-2 microglobulin component of a MHC class I molecule with an intracellular signalling domain within the cell.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 9, 2023
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, James Sillibourne, Lukas Stanczuk
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20230133682
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokinc and a cell-surface antigen; and (ii) a cytokine receptor cndodomain.
    Type: Application
    Filed: July 26, 2022
    Publication date: May 4, 2023
    Inventors: Martin PULÉ, Shaun CORDOBA, Matteo RIGHI, James SILLIBOURNE, Shimobi ONUOHA, Simon THOMAS
  • Methods for treating cancer or modulating T cells or NK cells in a subject with cancer by administering cells comprising chimeric cytokine receptors
    Patent number: 11479614
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: October 25, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • Methods for treating cancer or modulating T cells or NK cells in a subject by administering cells comprising chimeric transmembrane proteins
    Patent number: 11479613
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: October 25, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • CELL
    Publication number: 20220211830
    Abstract: The present invention provides a cell which comprises; (i) a chimeric antigen receptor (CAR) or a transgenic T-cell receptor (TCR); and (ii) at least one polypeptide capable of co-localizing an MHC class I polypeptide or an MHC class II polypeptide with an intracellular signalling domain within the cell.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 7, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, James Sillibourne, Farhaan Parekh
  • Cell
    Patent number: 11365262
    Abstract: The present invention provides a cell which comprises a first chimeric antigen receptor (CAR) and a second CAR, wherein the first and second CARs bind different epitopes on the same ligand. The cell may be used in a method for treating a disease, such as cancer.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 21, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20210040228
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 20, 2020
    Publication date: February 11, 2021
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20210040227
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 20, 2020
    Publication date: February 11, 2021
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • POLYPEPTIDES AND METHODS
    Publication number: 20210032335
    Abstract: The invention relates to a polypeptide comprising (i) an antigen binding domain (ii) a pre-T-alpha domain ectodomain; and (iii) a trans-membrane domain. The invention also relates to nucleic acids, kits, cells, methods and uses.
    Type: Application
    Filed: February 1, 2019
    Publication date: February 4, 2021
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Daniela Achkova, Callum McKenzie, James Sillibourne
  • Chimeric cytokine receptors and encoding nucleic acids
    Patent number: 10800854
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 13, 2020
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • Chimeric cytokine receptors and encoding nucleic acids
    Patent number: 10800855
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: October 13, 2020
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • VECTORS
    Publication number: 20200308600
    Abstract: The present invention provides a kit of vectors for transducing an immune cell with multiple transgenes comprising: (i) a first vector which comprises a first transgene and a nucleotide sequence encoding a transcription factor and; and (ii) a second vector which comprises a second transgene wherein expression of the second transgene within a host cell is dependent upon expression of the transcription factor.
    Type: Application
    Filed: October 24, 2018
    Publication date: October 1, 2020
    Inventors: Martin Pulé, James Sillibourne, Shaun Cordoba
  • CELL
    Publication number: 20200255494
    Abstract: The present invention provides a cell which comprises; (i) a chimeric antigen receptor (CAR) or a transgenic T-cell receptor (TCR); and (ii) a polypeptide capable of co-localizing a beta-2 microglobulin component of a MHC class I molecule with an intracellular signalling domain within the cell.
    Type: Application
    Filed: October 12, 2018
    Publication date: August 13, 2020
    Inventors: Martin Pulé, James Sillibourne, Lukas Stanczuk
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20190016820
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 17, 2019
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • CELL
    Publication number: 20180346595
    Abstract: The present invention provides a cell which comprises a first chimeric antigen receptor (CAR) and a second CAR, wherein the first and second CARs bind different epitopes on the same ligand. The cell may be used in a method for treating a disease, such as cancer.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 6, 2018
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20180244797
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 19, 2016
    Publication date: August 30, 2018
    Applicant: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas